Patents by Inventor Jianyong Shou

Jianyong Shou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof
    Patent number: 11787766
    Abstract: Provided are a compound for the prevention and treatment of diseases associated with PD-L1, a preparation method therefor and use thereof. Specifically, provided are the compound of formula I, the stereoisomer and the racemate thereof, or pharmaceutically acceptable salts thereof, and also provided is an application thereof in the preparation of a drug for the prevention and treatment of diseases associated with PD-L1.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: October 17, 2023
    Assignee: SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD.
    Inventors: Lei Jiang, Jianwen Deng, Xiaoli Lu, Ke Shang, Jianyong Shou, Bing Wang, Danyi Wu, Xueli Xu, Yuan Xu, Yi Zhang, Mingwei Zheng
  • USE OF BERBERINE ANALOG AND JAK INHIBITOR IN TREATMENT OF INFLAMMATORY DISEASES OF GASTROINTESTINAL TRACT
    Publication number: 20230293503
    Abstract: The present invention relates to a strategy for combining a berberine analog with a JAK inhibitor in the treatment of inflammatory diseases of the gastrointestinal tract. Specifically, provided by the present invention is a pharmaceutical composition containing the berberine analog and the JAK inhibitor, and a use thereof in the treatment of inflammatory diseases of the gastrointestinal tract. The composition may exhibit an improved effect over the use of berberine or the JAK inhibitor alone.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 21, 2023
    Inventors: Jianyong SHOU, Lei JIANG, Xian JIN, Shengyang LIU, Xudong MAO, Jianhua ZHANG
  • CODRUG THAT DISINTEGRATES IN INTESTINE, PREPARATION THEREFOR, AND USE THEREOF
    Publication number: 20230271982
    Abstract: The present invention relates to a codrug that cleaved in the gut, preparation therefor, and a use thereof. Specifically, provided is a codrug compound in formula I. Also provided are a method of using the present compound for the treatment of gastrointestinal tract autoimmune diseases, inflammatory diseases, and cancers, as well as a method and an intermediate for preparing the present compound.
    Type: Application
    Filed: July 19, 2021
    Publication date: August 31, 2023
    Inventors: Jianyong SHOU, Xiang AO, Lei JIANG, Shengyang LIU, Xudong MAO, Zhi QIAO, Xiaoping XIE, Jianhua ZHANG
  • FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR
    Publication number: 20220144827
    Abstract: A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.
    Type: Application
    Filed: November 13, 2019
    Publication date: May 12, 2022
    Inventors: Lei JIANG, Zhiyong FENG, Xian JIN, Zhi QIAO, Jianyong SHOU, Ke SHANG, Danyi WU, Lingling XU, Yuan XU, Shuyun ZHANG, Yi ZHANG, Yuxing ZHANG
  • PREPARATION AND APPLICATION OF CLASS OF N-CONTAINING HETEROCYCLIC COMPOUNDS HAVING IMMUNOREGULATORY FUNCTION
    Publication number: 20220056023
    Abstract: The present invention discloses the preparation and application of heterocyclic compound having immunoregulatory function. Specifically, the present invention discloses a compound having a structure according to Formula I, wherein the definition of each group is as described in the specification. The invention also provides the use of the compounds in regulating immunity and inhibiting PD-1/PD-L1.
    Type: Application
    Filed: July 31, 2019
    Publication date: February 24, 2022
    Inventors: Yi ZHANG, Jianwen DENG, Zhiyong FENG, Lei JIANG, Xiaoli LU, Ke SHANG, Jianyong SHOU, Bing WANG, Xueli XU, Yuan XU
  • SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR
    Publication number: 20220017512
    Abstract: Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.
    Type: Application
    Filed: November 13, 2019
    Publication date: January 20, 2022
    Inventors: Lei JIANG, Zhiyong FENG, Xian JIN, Zhi QIAO, Jianyong SHOU, Ke SHANG, Danyi WU, Lingling XU, Yuan XU, Shuyun ZHANG, Yi ZHANG, Yuxing ZHANG
  • AROMATIC HETEROCYCLIC COMPOUND WITH KINASE INHIBITORY ACTIVITY
    Publication number: 20210371415
    Abstract: Provided are a JAK kinase inhibitor, preparation and use thereof. In particular, provided is a compound of Formula I, wherein each group is as described in the specification. The compound has an excellent JAK inhibitory activity, and therefore can be used to prepare pharmaceutical compositions for the treatment of cancer and other diseases related to JAK activity.
    Type: Application
    Filed: September 23, 2019
    Publication date: December 2, 2021
    Inventors: Lei JIANG, Jianwen DENG, Zhiyong FENG, Shengyang LIU, Xudong MAO, Ke SHANG, Jianyong SHOU, Danyi WU, Xiaoping XIE, Yuan XU, Haixia ZHAO, Jianhua ZHANG, Mingwei ZHENG
  • PREPARATION AND APPLICATION OF AROMATIC COMPOUND HAVING IMMUNOREGULATORY FUNCTION
    Publication number: 20210347785
    Abstract: Provided are an aromatic compound having immunoregulatory effect, a preparation method thereof, and a use of the same in regulating immune responses or inhibiting PD-1/PD-L1.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 11, 2021
    Inventors: Yi ZHANG, Jianwen DENG, Zhiyong FENG, Lei HUANG, Lei JIANG, Xiaoli LU, Ke SHANG, Jianyong SHOU, Bing WANG, Xueli XU, Yuan XU
  • COMPOUND HAVING PD-L1 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20200392083
    Abstract: Provided are a compound for the prevention and treatment of diseases associated with PD-L1, a preparation method therefor and use thereof. Specifically, provided are the compound of formula I, the stereoisomer and the racemate thereof, or pharmaceutically acceptable salts thereof, and also provided is an application thereof in the preparation of a drug for the prevention and treatment of diseases associated with PD-Ll.
    Type: Application
    Filed: August 17, 2018
    Publication date: December 17, 2020
    Inventors: Lei JIANG, Jianwen DENG, Xiaoli LU, Ke SHANG, Jianyong SHOU, Bing WANG, Danyi WU, Xueli XU, Yuan XU, Yi ZHANG, Mingwei ZHENG
  • Notch receptor agonists and uses
    Patent number: 6689744
    Abstract: The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: February 10, 2004
    Assignee: Genentech, Inc.
    Inventors: Wei-Qiang Gao, Hartmut Koeppen, Sarajane Ross, Jianyong Shou
  • Notch receptor agonists and uses
    Publication number: 20030082651
    Abstract: The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.
    Type: Application
    Filed: September 17, 2001
    Publication date: May 1, 2003
    Applicant: GENENTECH, INC.
    Inventors: Wei-Qiang Gao, Hartmut Koeppen, Sarajane Ross, Jianyong Shou
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20030055224
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: August 14, 2001
    Publication date: March 20, 2003
    Applicant: GENENTECH, INC.
    Inventors: Wei-Qiang Gao, Paul Polakis, Jianyong Shou, Victoria Smith, Robert Soriano, P. Mickey Williams, Thomas D. Wu, Zemin Zhang