Abstract: Provided by the present invention are an antibody against human TIM-3 or an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody, an expression vector for expressing the antibody and a host cell, and a method for producing the antibody. Further provided by the present invention are a pharmaceutical composition comprising the antibody or an antigen-binding fragment of the antibody, and an application of the pharmaceutical composition in the preparation of a medicine, the medicine is used for preventing and/or treating various diseases (including tumors, infectious diseases and autoimmune diseases).

Abstract: Provided are a cash box and a cash recycling and handling device. The cash box comprises a box body, a supporting plate and a self-locking assembly, where the self-locking assembly includes a stop plate disposed between a side wall of the box body and the supporting plate, and the stop plate is movably connected to the box body and has a lifted position and a lowered position; in a case where the stop plate is in the lifted position, the stop plate is in fit with the supporting plate to lock a position of the supporting plate; and in a case where the stop plate is in the lowered position, the stop plate is separated from the supporting plate to unlock the position of the supporting plate. The cash recycling and handling device includes at least one above-mentioned cash box.

Abstract: The present invention discloses a compound fluorine-free foam extinguishing agent and a preparation method therefor, comprising components of the following parts by weight: 6-8 parts of alkyl glycoside, 10-14 parts of polysiloxane quaternary ammonium salt, 0.5-1 part of silicon dioxide and 60-65 parts of water. The compound fluorine-free foam extinguishing agent prepared by the present invention has a high stability, a high expansion, an obvious fire extinguishing effect and a higher environment-friendliness. The polysiloxane quaternary ammonium salt contains hydrophobic polysiloxane long chains, has a high temperature resistance, and collaborates with the alkyl glycoside to be adsorbed on the surface of silicon dioxide particles, which improves the stability of the silicon dioxide in a solution and reduces the surface tension of the solution.

Abstract: The present disclosure provides a method for preparing multi-component polymers through post-polymerization modification, used to functionalize polysulfonyl imidate polymer including a dispersing polymer reactant, an electrophilic substitution reagent and a catalyst in an organic dispersant; adding acid-binding agent to react at room temperature for 4-48 h; obtaining the precipitate when the reaction finished; washing and drying the obtained precipitate to get the functionalized multi-component polymers. The present disclosure involves a low polymerization temperature, allowing for the reaction to occur at room temperature. Additionally, the conversion rate is high, and the applicable electrophilic substitution monomer reagents have a wide selection. Besides that, the synthesis cost of the reaction is low due to the widespread availability of common chemical reagents such as catalysts, organic dispersants, acid binding agents, and other reaction reagents.

Abstract: The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.

Abstract: Disclosed are a sheet-type medium conveying device and a cash recycling and handling apparatus. The sheet-type medium conveying device includes a first passage plate, a second passage plate and a driving mechanism. The first passage plate and the second passage plate are oppositely arranged. A passage is formed between the first passage plate and the second passage plate, and configured for a sheet-type medium to pass through. The driving mechanism is configured to drive a first end of the first passage plate and a first end of the second passage plate to get close to or away from each other.

Abstract: A sheet-type medium accumulating and separating device includes a frame and a paper pressing mechanism. The frame is provided with an storage cavity for accommodating sheet-type media. The storage cavity is provided with a paper inlet, a paper outlet, and a paper kicking roller. A paper supporting plate for supporting the media is further provided in the storage cavity. The paper pressing mechanism includes a paper pressing plate and a driving assembly. The paper pressing plate is provided with a first position and a second position arranged in the direction of stacking. The paper pressing plate includes a paper pressing part arranged within the storage cavity. The driving assembly is in transmission connection with the paper pressing plate. When the paper pressing plate is in the first position, the paper pressing part is adjacent to the paper outlet, to press the sheet-type media towards the paper kicking roller.

Abstract: Provided are a cash storage apparatus and a cash recycling and processing device. The cash storage apparatus includes a cabinet and a banknote box assembly. The cabinet is provided with a first inlet/outlet at a top of the cabinet and two guiding parts inside the cabinet. The two guiding parts are arranged in a first direction at an interval. Each guiding part includes a guiding rail extending in a second direction vertical to the first direction. The guiding rail is provided with a locating part. The banknote box assembly is provided with a second inlet/outlet at a top of the banknote box assembly and two first movable parts. The two first movable parts are arranged in movable fit with the two guiding rails respectively.

Abstract: The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.

Abstract: Provided are a transmission mechanism, a sheet-type medium processing device, and an automatic teller machine. The transmission mechanism includes a first frame (100), a second frame (200), and a transmission assembly; the transmission assembly includes a mounting frame (310), a first transmission member (330), a second transmission member (340), and an elastic member (320). The mounting frame (310) is movably disposed on the first frame (100), the first transmission member (330) is disposed on the mounting frame(310), the second transmission member (340) is disposed on the second frame (200), the elastic member (320) is connected between the mounting frame (310) and the first frame (100), and the elastic member (320) is configured to enable the mounting frame (310) to drive the first transmission member (330) to move in a set direction, so that the first transmission member (330) is mated with the second transmission member (340).

Abstract: The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.

Abstract: Provided by the present invention are an antibody against human TIM-3 or an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody, an expression vector for expressing the antibody and a host cell, and a method for producing the antibody. Further provided by the present invention are a pharmaceutical composition comprising the antibody or an antigen-binding fragment of the antibody, and an application of the pharmaceutical composition in the preparation of a medicine, the medicine is used for preventing and/or treating various diseases (including tumors, infectious diseases and autoimmune diseases).

Abstract: A vending machine and an item dispensing method. The vending machine includes: a storage column used to store items; a bucket used to receive an item from the storage column; a first conveying mechanism disposed at the storage column and used to convey the item in the storage column to the bucket; a second conveying mechanism disposed at the bucket and used to convey the item from the storage column to the inside of the bucket; and a controller. The first and second conveying mechanisms are each electrically connected to the controller. The item dispensing method includes controlling the first conveying mechanism to convey an item to the bucket at a first preset speed and controlling the second conveying mechanism to convey the item to the inside of the bucket at a second preset speed, as the item is entering the bucket, the first preset speed being less than the second preset speed.

Abstract: Provided are a cash storage apparatus and a cash recycling and processing device. The cash storage apparatus includes a cabinet and a banknote box assembly. The cabinet is provided with a first inlet/outlet at a top of the cabinet and two guiding parts inside the cabinet. The two guiding parts are arranged in a first direction at an interval. Each guiding part includes a guiding rail extending in a second direction vertical to the first direction. The guiding rail is provided with a locating part. The banknote box assembly is provided with a second inlet/outlet at a top of the banknote box assembly and two first movable parts. The two first movable parts are arranged in movable fit with the two guiding rails respectively.

Abstract: A vending machine and an item dispensing method. The vending machine includes: a storage column used to store items; a bucket used to receive an item from the storage column; a first conveying mechanism disposed at the storage column and used to convey the item in the storage column to the bucket; a second conveying mechanism disposed at the bucket and used to convey the item from the storage column to the inside of the bucket; and a controller. The first and second conveying mechanisms are each electrically connected to the controller. The item dispensing method includes controlling the first conveying mechanism to convey an item to the bucket at a first preset speed and controlling the second conveying mechanism to convey the item to the inside of the bucket at a second preset speed, as the item is entering the bucket, the first preset speed being less than the second preset speed.

Abstract: Provided are a cash box and a cash recycling and handling device. The cash box comprises a box body, a supporting plate and a self-locking assembly, where the self-locking assembly includes a stop plate disposed between a side wall of the box body and the supporting plate, and the stop plate is movably connected to the box body and has a lifted position and a lowered position; in a case where the stop plate is in the lifted position, the stop plate is in fit with the supporting plate to lock a position of the supporting plate; and in a case where the stop plate is in the lowered position, the stop plate is separated from the supporting plate to unlock the position of the supporting plate. The cash recycling and handling device includes at least one above-mentioned cash box.

Abstract: Disclosed are a sheet-type medium conveying device and a cash recycling and handling apparatus. The sheet-type medium conveying device includes a first passage plate, a second passage plate and a driving mechanism. The first passage plate and the second passage plate are oppositely arranged. A passage is formed between the first passage plate and the second passage plate, and configured for a sheet-type medium to pass through. The driving mechanism is configured to drive a first end of the first passage plate and a first end of the second passage plate to get close to or away from each other.

Abstract: The invention discloses a multi-plug DC charging pile system, the number of whose charging modules can reach more than 6, while the number of plugs is only half of the number of charging modules. Each charging module can be switched to any plug. At the same time, the economy, practicability and stability of the product are improved. The multi-plug DC charging pile system includes: six DC charging modules, three plugs, a main control board, a switching control board and sixteen DC contactors. The main control board controls the output of six DC charging modules through CAN. The main control board is connected with the switching control board. The main control board is connected with three plugs through CAN. The sixteen DC contactors are connected with one of three plugs respectively. The switching control board controls the on-off of sixteen DC contactors to control the DC charging power obtained by three plugs.

Abstract: The invention provides compounds for modulating glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.