Patents by Inventor Jianzhang Mei

Jianzhang Mei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIFLUOROALKYLCYCLOPROPYL AMINO ACIDS AND ESTERS, AND SYNTHESES THEREOF
    Publication number: 20200115329
    Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: September 23, 2019
    Publication date: April 16, 2020
    Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
  • SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS
    Publication number: 20200095230
    Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
    Type: Application
    Filed: September 27, 2019
    Publication date: March 26, 2020
    Inventors: Russell D. Cink, Kirill A. Lukin, Marvin R. Leanna, Matthew J. Pelc, Timothy B. Towne, Dennie S. Welch, Kenneth M. Engstrom, Matthew M. Ravn, Richard D. Bishop, Gang Zhao, Jianzhang Mei, Jeff M. Kallemeyn, David R. Hill, Michael J. Abrahamson, Westin H. Morrill
  • ENZYMATIC PROCESS FOR THE PREPARATION OF (1S,2R)-2-(DIFLUOROMETHYL)-1-(PROPOXYCARBONYL)CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20200024621
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: June 7, 2019
    Publication date: January 23, 2020
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Stefan Mix, Gareth J. Brown
  • Synthetic route to anti-viral agents
    Patent number: 10442792
    Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 15, 2019
    Assignee: AbbVie Inc.
    Inventors: Russell D. Cink, Kirill A. Lukin, Marvin R. Leanna, Matthew J. Pelc, Timothy B. Towne, Dennie S. Welch, Kenneth M. Engstrom, Matthew M. Ravn, Richard D. Bishop, Gang Zhao, Jianzhang Mei, Jeff M. Kallemeyn, David R. Hill, Michael J. Abrahamson, Westin H. Morrill
  • Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof
    Patent number: 10421712
    Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 24, 2019
    Assignee: AbbVie Inc.
    Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
  • Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid
    Patent number: 10316338
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Abb Vie Inc.
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Gareth J. Brown, Stefan Mix
  • SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS
    Publication number: 20190084966
    Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Russell D. Cink, Kirill A. Lukin, Marvin R. Leanna, Matthew J. Pelc, Timothy B. Towne, Dennie S. Welch, Kenneth M. Engstrom, Matthew M. Ravn, Richard D. Bishop, Gang Zhao, Jianzhang Mei, Jeff M. Kallemeyn, David R. Hill, Michael J. Abrahamson, Westin H. Morrill
  • Synthetic route to anti-viral agents
    Patent number: 10077256
    Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: September 18, 2018
    Assignee: AbbVie Inc.
    Inventors: Russell D. Cink, Kirill A. Lukin, Marvin R. Leanna, Matthew J. Pelc, Timothy B. Towne, Dennie S. Welch, Kenneth M. Engstrom, Matthew M. Ravn, Richard D. Bishop, Gang Zhao, Jianzhang Mei, Jeff M. Kallemeyn, David R. Hill, Michael J. Abrahamson, Westin H. Morrill
  • DIFLUOROALKYLCYCLOPROPYL AMINO ACIDS AND ESTERS, AND SYNTHESES THEREOF
    Publication number: 20180194721
    Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: October 20, 2017
    Publication date: July 12, 2018
    Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
  • SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS
    Publication number: 20180057482
    Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Inventors: Russell D. Cink, Kirill A. Lukin, Marvin R. Leanna, Matthew J. Pelc, Timothy B. Towne, Dennie S. Welch, Kenneth M. Engstrom, Matthew M. Ravn, Richard D. Bishop, Gang Zhao, Jianzhang Mei, Jeff M. Kallemeyn, David R. Hill, Michael J. Abrahamson, Westin H. Morrill
  • Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof
    Patent number: 9809534
    Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: November 7, 2017
    Assignee: AbbVie INC.
    Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
  • Synthetic route to anti-viral agents
    Patent number: 9809576
    Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: November 7, 2017
    Assignee: AbbVie Inc.
    Inventors: Russell D. Cink, Kirill A. Lukin, Marvin R. Leanna, Matthew J. Pelc, Timothy B. Towne, Dennie S. Welch, Kenneth M. Engstrom, Matthew M. Ravn, Richard D. Bishop, Gang Zhao, Jianzhang Mei, Jeff M. Kallemeyn, David R. Hill, Michael J. Abrahamson, Westin H. Morrill
  • Macrocyclic hepatitis C serine protease inhibitors
    Patent number: 9309279
    Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: April 12, 2016
    Assignees: AbbVie Inc., Enanta Pharmaceuticals, Inc.
    Inventors: Yiyin Ku, Keith F. McDaniel, Hui-Ju Chen, Jason P. Shanley, Dale J. Kempf, David J. Grampovnik, Ying Sun, Dong Liu, Yonghua Gai, Yat Sun Or, Seble H. Wagaw, Kenneth Engstrom, Tim Grieme, Ahmad Sheikh, Jianzhang Mei
  • MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
    Publication number: 20140148573
    Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 29, 2014
    Applicants: Enanta Pharmaceuticals, Inc., AbbVie, Inc.
    Inventors: Yiyin Ku, Keith F. McDaniel, Hui-Ju Chen, Jason P. Shanley, Dale J. Kempf, David J. Grampovnik, Ying Sun, Dong Liu, Yonghua Gai, Yat Sun Or, Seble H. Wagaw, Kenneth Engstrom, Tim Grieme, Ahmad Sheikh, Jianzhang Mei
  • MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
    Publication number: 20120196792
    Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
    Type: Application
    Filed: April 4, 2012
    Publication date: August 2, 2012
    Applicants: ENANTA PHARMACEUTICALS, INC., ABBOTT LABORATORIES
    Inventors: Yiyin Ku, Keith F. McDaniel, Hui-Ju Chen, Jason P. Shanley, Dale J. Kempf, David J. Grampovnik, Ying Sun, Dong Liu, Yonghua Gai, Yat Sun Or, Seble H. Wagaw, Ken Engstrom, Tim Grieme, Ahmad Sheikh, Jianzhang Mei
  • Processes to make apoptosis promoters
    Patent number: 8168784
    Abstract: Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: May 1, 2012
    Assignee: Abbott Laboratories
    Inventors: Thaddeus Stephan Franczyk, II, David R. Hill, Anthony Ralph Haight, Maureen Ann McLaughlin, Shashank Shekhar, Su Yu, Jianzhang Mei, Lei Wang
  • Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate
    Patent number: 7745448
    Abstract: A crystalline N-(4-(4-aminothieno[2,3 -d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate characterized in the monoclinic crystal system and P21/n space group, when measured with radiation at 0.7107 ?, by lattice parameters a, b and c of 5.0318 ?±0.006 ?, 23.684 ?±0.002 ? and 18.877 ?±0.002 ?, respectively, and ? of 90.703±0.003, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 29, 2010
    Assignee: Abbott Laboratories Inc.
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok, Rodger Henry
  • Crystalline N-(4-(4-ammoniumthieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea benzenesulfonate
    Patent number: 7745622
    Abstract: A crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea benzenesulfonate characterized in the triclinic crystal system and P-1 space group, when measured with radiation at 0.7107 ?, by lattice parameters a, b and c of 7.800 ?±0.001 ?, 13.406 ?±0.002 ? and 13.554 ?±0.002 ?, respectively and ?, ? and ? of 67.155±0.002, 79.724°±0.002° and 84.067±0.002, respectively, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 29, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok, Rodger Henry
  • Macrocyclic hepatitis C serine protease inhibitors
    Publication number: 20100144608
    Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
    Type: Application
    Filed: September 10, 2009
    Publication date: June 10, 2010
    Inventors: Yiyin Ku, Keith F. McDaniel, Hui-Ju Chen, Jason P. Shanley, Dale J. Kempf, David J. Grampovnik, Ying Sun, Dong Liu, Yonghua Gai, Yat Sun Or, Seble H. Wagaw, Ken Engstrom, Tim Grieme, Ahmad Sheikh, Jianzhang Mei
  • Processes To Make Apoptosis Promoters
    Publication number: 20090318689
    Abstract: Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.
    Type: Application
    Filed: June 17, 2009
    Publication date: December 24, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Thaddeus Stephan Franczyk, II, David R. Hill, Anthony Ralph Haight, Maureen Ann McLaughlin, Shashank Shekhar, Su Yu, Jianzhang Mei, Lei Wang