Abstract: A new dry powder inhaler is developed as a pulmonary medicine delivery device for dispersing precise tiny dosages (10 ?g-50 mg) of pure carrier-free ultra-fine powdered medicament (<5 ?m aerodynamics particle size) into a patient's lung. The powder is drawn from the blister cell and dispersed through an outlet tube assisted by two air streams. The first air stream goes through a the blister cell from its upstream side, to significantly fluidize the medicament in the dose to flow upward. The second one extracts the fluidized powder from downstream of the blister cell for further deagglomeration and dispersion of the medicament powder by shear force. The rotating multi-dose blister can hold up to 60 doses, which are pre-metered with pure ultra-fine powdered medicament. So that it has higher drug loading capability in small volumes, compared to most current dry powder inhalers, which usually use some excipient.

Abstract: A new dry powder inhaler is developed as a pulmonary medicine delivery device for dispersing precise tiny dosages (10 ?g-50 mg) of pure carrier-free ultra-fine powdered medicament (<5 ?m aerodynamics particle size) into a patient's lung. The powder is drawn from the blister cell and dispersed through an outlet tube assisted by two air streams. The first air stream goes through a the blister cell from its upstream side, to significantly fluidize the medicament in the dose to flow upward. The second one extracts the fluidized powder from downstream of the blister cell for further deagglomeration and dispersion of the medicament powder by shear force. The rotating multi-dose blister can hold up to 60 doses, which are pre-metered with pure ultra-fine powdered medicament. So that it has higher drug loading capability in small volumes, compared to most current dry powder inhalers, which usually use some excipient.

Abstract: The present invention provides a fluidized bed for dispensing small quantities of powders. The fluidized bed is made using a porous housing to permit injection and removal of fluid through the surrounding walls to improve the operation of the bed particularly for small particles of the group C size, including significantly reducing powder adhesion to the walls. In one aspect of the invention the fluidized bed housing is rotated about its longitudinal axis, which may be oriented at any suitable angle. A system for changing the volume of the bed is described as is a system for incorporating injection nozzles within the bed for constant agitation and prevention of powder adhering to the walls of the housing.

Abstract: The present invention provides a fluidized bed for dispensing small quantities of powders. The fluidized bed is made using a porous housing to permit injection and removal of fluid through the surrounding walls to improve the operation of the bed particularly for small particles of the group C size, including significantly reducing powder adhesion to the walls. In one aspect of the invention the fluidized bed housing is rotated about its longitudinal axis, which may be oriented at any suitable angle. A system for changing the volume of the bed is described as is a system for incorporating injection nozzles within the bed for constant agitation and prevention of powder adhering to the walls of the housing.