Abstract: The present invention discloses a method for selecting a real-time service data transmission path, comprising establishing an independent bearer control layer comprising more than one bearer network resource manager between a service control layer and a bearer network. The method further comprises: after a source bearer network resource manager which is connected to the service control layer receives a connection request for a real-time service, orderly selecting and determining, from the source bearer network resource manager towards a destination bearer network resource manager, an intra-domain route path for the real-time service in a management domain corresponding to each bearer network resource manager, and an inter-domain route path between adjacent management domains corresponding to adjacent bearer network resource managers. In addition, the present invention discloses six methods for selecting a real-time service data transmission path based on different strategies.

Abstract: Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.

Abstract: The invention discloses a method for providing guaranteed Quality of Services (QoS) in an IP network. In the invention, separated with the function of route selection for IP packets in IP bearer network, the same function for services with guaranteed QoS requirements is accomplished by bearer network resource managers in bearer control layer. After completing the route selection according to network resource occupation condition, the bearer network resource managers control the edge routers so that the traffic streams can be forwarded according to the path designated by the resource manager in the bearer network with multi-level label stack technology. The invention also discloses a system for providing guaranteed QoS in an IP network. The method and system according to the invention have good expansibility and little impact to the prior network.

Abstract: A method for realizing route forwarding in a network, including: establishing LSPs in a bearer network; setting an entrance label in the starting node of each LSP pointing to forwarding information of the LSP; a bearer control entity assigning a transfer path for the service flow and sending the information of all corresponding entrance labels of the transfer path to the ingress edge node of the transfer path; when the service flow needs to be forwarded, the ingress edge node puts the label stack into the data packet of the service flow to generate an MPLS exchange packet; and forwarding the MPLS exchange packet in the bearer network according to the label stack until the packet reaches the egress edge node of the transfer path. The present invention grants high compatibility to the network, minimizes the network investment, and reduces the difficulties in network implementation.

Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.

Abstract: The invention provides methods of modulating the activity of MurA polypeptides, particularly to treat disease.

Abstract: Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.

Abstract: The invention discloses a method for providing guaranteed Quality of Services (QoS) in an IP network. In the invention, separated with the function of route selection for IP packets in IP bearer network, the same function for services with guaranteed QoS requirements is accomplished by bearer network resource managers in bearer control layer. After completing the route selection according to network resource occupation condition, the bearer network resource managers control the edge routers so that the traffic streams can be forwarded according to the path designated by the resource manager in the bearer network with multi-level label stack technology. The invention also discloses a system for providing guaranteed QoS in an IP network. The method and system according to the invention have good expansibility and little impact to the prior network.

Abstract: The invention discloses a method for providing services with guaranteed Quality of Service (QoS) in an IP access network. In this method, when the network control layer applies for network resources to the access network as response to the service request of needing guaranteed QoS, the edge router determines whether the access network can provide enough resources for the service. If there are enough resources, the edge router sends QoS parameters to the access network end devices which make QoS control to get a guaranteed QoS.

Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.

Abstract: The invention provides ups (undecaprenyl diphosphate synthase) polypeptides and polynucleotides encoding ups (undecaprenyl diphosphate synthase) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (undecaprenyl diphosphate synthase) polypeptides to screen for antibacterial compounds.

Abstract: The invention provides ups (ugc) polypeptides and polynucleotides encoding ups (ugc) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (ugc) polypeptides to screen for antibacterial compounds.

Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides ups polypeptides and polynucleotides encoding ups polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups polypeptides to screen for antibacterial compounds.

Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.

Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ttA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides fabG polypeptides and polynucleotides encoding fabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabG polypeptides to screen for antibacterial compounds.

Abstract: The invention provides MurA polypeptides and polynucleotides encoding MurA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides dbpB polypeptides and DNA (RNA) encoding dbpB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dbpB polypeptides to screen for antibacterial compounds.