Patents by Inventor Jiaur Rahaman Gayen

Jiaur Rahaman Gayen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMAC MIMETICS FOR TREATMENT OF CANCER, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF
    Publication number: 20240083846
    Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.
    Type: Application
    Filed: December 17, 2021
    Publication date: March 14, 2024
    Inventors: Wahajul HAQ, Rafat ALI, Akhilesh SINGH, Mushtaq Ahmad NENGROO, Roshan KATEKAR, Gajendra SINGH, Jayanti VAISHNAV, Mohammad AFSAR, Manohar SINGH, Srikanta Kumar RATH, Dipankar KOLEY, Durga Prasad MISHRA, Ravishankar RAMACHANDRAN, Ravi Sankar AMPAPATHI, Jiaur Rahaman GAYEN, Dipak DATTA
  • Bioactive extract, fraction of and formulation thereof for bone regeneration
    Patent number: 11304927
    Abstract: The present invention relates to a bioactive extract, fraction of Cassia occidentalis and formulation thereof for bone regeneration and treatment of glucocorticoid induced musculo-skeletal diseases and associated electrolyte imbalances.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 19, 2022
    Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Naibedya Chattopadhayay, Subhashis Pal, Sudhir Kumar, Ramakrishna Eppalapally, Padam Kumar, Sapana, Jiaur Rahaman Gayen, Riyazuddin Mohammed, Sabyasachi Sanyal, Anagha Gurjar, Prabhat Ranjan Mishra, Naresh Mittapelly, Kamal Ram Arya, Brijesh Kumar, Srikanta Rath, Arun Kumar Trivedi, Maurya Rakesh
  • Combination of clofazimine and imatinib for effective therapy of drug-resistant myeloid leukemia
    Patent number: 10576078
    Abstract: The present invention relates to method of treating chronic myeloid leukemia (CML) or drug resistant CML comprising, administering to human being or any other mammal or animal in need thereof, a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition; or a combination of a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition with a tyrosine kinase inhibitor (TKI). The invention also provides the kit for treatment of CML or drug resistant CML.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 3, 2020
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Sabyasachi Sanyal, Harish Kumar, Naibedya Chattopadhyay, Ravishankar Ramachandran, Arun Kumarv Trivedi, Sonal Shree, Anagha Ashok Gurjar, Sourav Chattopadhyay, Sapana Kushwaha, Abhishek Kumar Singh, Shikha Dubey, Kiran Lata, Riyazuddin Mohammed, Jiaur Rahaman Gayen, Anil Kumar Tripathi
  • BIOACTIVE EXTRACT, FRACTION OF CASSIA OCCIDENTALIS AND FORMULATION THEREOF FOR BONE REGENERATION
    Publication number: 20190374504
    Abstract: The present invention relates to a bioactive extract, fraction of Cassia occidentalis and formulation thereof for bone regeneration and treatment of glucocorticoid induced musculo-skeletal diseases and associated electrolyte imbalances.
    Type: Application
    Filed: June 7, 2019
    Publication date: December 12, 2019
    Inventors: Naibedya CHATTOPADHAYAY, Subhashis PAL, Sudhir KUMAR, Ramakrishna EPPALAPALLY, Padam KUMAR, Sapana, Jiaur Rahaman GAYEN, Riyazuddin MOHAMMED, Sabyasachi SANYAL, Anagha GURJAR, Prabhat Ranjan MISHRA, Naresh MITTAPELLY, Kamal Ram ARYA, Brijesh KUMAR, Srikanta RATH, Arun Kumar TRIVEDI, Maurya RAKESH
  • Combination Of Clofazimine And Imatinib For Effective Therapy Of Drug-Resistant Myeloid Leukemia
    Publication number: 20190350928
    Abstract: The present invention relates to method of treating chronic myeloid leukemia (CML) or drug resistant CML comprising, administering to human being or any other mammal or animal in need thereof, a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition; or a combination of a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition with a tyrosine kinase inhibitor (TKI). The invention also provides the kit for treatment of CML or drug resistant CML.
    Type: Application
    Filed: August 30, 2018
    Publication date: November 21, 2019
    Inventors: Sabyasachi Sanyal, Harish Kumar, Naibedya Chattopadhyay, Ravishankar Ramachandran, Arun Kumarv Trivedi, Sonal Shree, Anagha Ashok Gurjar, Sourav Chattopadhyay, Sapana Kushwaha, Abhishek Kumar Singh, Shikha Dubey, Kiran Lata, Riyazuddin Mohammed, Jiaur Rahaman Gayen, Anil Kumar Tripathi
  • Ulmoside-A: Useful For Prevention Or Cure Of Metabolic Diseases
    Publication number: 20160193240
    Abstract: The present invention relates to ulmoside A as a novel small molecule adiponectin receptor agonist useful for prevention or cure of metabolic diseases. The present invention further relates to the use of ulmoside-A (ULMA) ((2S,3S)-(+)-3?,4?,5,7-tetrahydroxydihydroflavonol-6-C-?-D-glucopyranoside) for alleviation, management or prevention or treatment of steroid-induced metabolic disorder. The present invention further relates to a pharmaceutical composition useful for prevention and/or treatment of various medical indications associated with metabolic diseases caused in humans and animals.
    Type: Application
    Filed: July 14, 2014
    Publication date: July 7, 2016
    Inventors: Sabyasachi Sanyal, Naibedya Chattopadhyay, Rakesh Maurya, Jiaur Rahaman Gayen, Smrati Bhadauria, Arun Kumar Trivedi, Abhishek Kumar Singh, Jay Sharan Mishra, Rashmi Kumari, Kunal Sharan, Parvez Mohammad Khan, Kainat Khan, Nidhi Singh, Shailendra Kumar Dhar Dwivedi, Manisha Yadav, Preety Dixit, Devendra Pratap Mishra, Sharad Sharma, Ram Arya Kamal