Abstract: An LED lighting device includes a seat, an optical assembly and a light source. The seat has a baseplate and a sidewall. A chamber is formed between the baseplate and the sidewall. The optical assembly completely covers a light-emitting side of the LED lighting device. The light source is disposed in the chamber of the seat and includes multiple LED arrays. Each LED array includes an LED chip. The optical assembly includes an optical unit. The optical unit includes multiple first optical members and multiple second optical members corresponding to the first optical members. The LED arrays correspond to the first optical members. Each first optical member possesses an effect of light diffusion resulting from its own material property. Each second optical member includes one or more sets of optical walls. Each set of optical walls surrounds one of the first optical members.

Abstract: The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes—but is not limited to—liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.

Abstract: A method for improving estimation of leaf area index in an early growth stage of wheat based on red-edge bands of Sentinel-2 satellite images includes the following steps: acquiring field background spectrum and wheat canopy spectrum information by means of Sentinel-2; respectively acquiring a “straw-soil” spectrum and a “wheat-straw-soil” spectrum, and calculating slopes of red-edge areas of the “straw-soil” spectrum and the “wheat-straw-soil” spectrum; calculating a tangent function SATF corrected by a background adjustment coefficient ?; constructing a wheat LAI estimation model based on a spectral variable SATFNIR-RE2; performing preliminary screening on the LAI estimation model using cross validation; and then testing the screened model with independent data.

Abstract: A TVS device may include a substrate, comprising a polarity of a first type, a first dopant layer, disposed on a first main surface of the substrate, and comprising a polarity of a second type, wherein the first dopant layer forms a P/N junction with the substrate. The TVS device may further include a second dopant layer, disposed on a second main surface of the substrate, opposite the first main surface, the second layer comprising the polarity of the first type, and a patterned layer, disposed on the second main surface of the substrate, the patterned layer comprising the polarity of the second type, wherein the patterned layer is interspersed with the second layer.

Abstract: A fracturing apparatus is provided. The fracturing apparatus includes a plunger pump, a transmission shaft, a main motor, an oil pipe, a first radiator and a noise reduction cabin. The main motor is spaced apart from the plunger pump, the plunger pump is connected with the main motor through the transmission shaft; the oil pipe is configured to be connected with the plunger pump; the first radiator is spaced apart from the plunger pump, the first radiator is configured to dissipate heat from oil in the oil pipe, the main motor, the first radiator and at least part of the oil pipe are all located inside the noise reduction cabin, and the plunger pump is located outside the noise reduction cabin.

Abstract: A method for logic design partitioning includes: collecting an RTL design file used for describing a logic circuit; performing syntax analysis processing on the RTL design file; extracting an always object and an assign object from logic model objects, and encapsulating the always object and the assign object, respectively; constructing and generating a hypergraph-based data structure; performing attribute analysis, and obtaining operating frequency information by processing according to clock domain information; associating and storing the clock domain information and the operating frequency information with corresponding nodes; and performing partitioning processing to obtain corresponding partitioned data. By means of the solutions of the present invention, other processing at the back end of the flow is not affected, the partitioning time is reduced and the partitioning efficiency is improved. Meanwhile, the logic content in chip design is partitioned efficiently, reasonably and correctly.

Abstract: Provided herein is technology relating to molecular biological manipulation of genes and genomes and particularly, but not exclusively, to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) methods, compositions, systems, and kits for improved genetic editing.

Abstract: The present invention relates to nanoparticles complexed with therapeutic agents configured for treating cardiovascular related disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying therapeutic agents configured for treating cardiovascular related disorders, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutic agents, imaging agents, and/or targeting agents (e.g., in cardiovascular disease diagnosis and/or therapy, etc.))).

Abstract: The present invention relates to N-acyl amino acid products and their use in diagnosing and treating disease.

Abstract: A method comprising administering to a subject having an aneurysm, suspected of having an aneurysm, or at risk of developing an aneurysm, a therapeutically effective amount of a compound selected from (i) a nitroalkene fatty acid, (ii) an unsaturated fatty acid having an electron withdrawing group, a leaving group, and a carbon-carbon double bond disposed between the electron withdrawing group and the leaving group, (iii) a thiolated nitro fatty acid, (iv) a dicarboxylic acid compound containing an electron withdrawing group, or a mixture of at least two of (i)-(iv).

Abstract: The present disclosure provides a method of treating NAFLD, NASH, and atherosclerosis, comprising administering glycine-containing tripeptide molecule, or a pharmaceutically acceptable salt thereof to a subject.

Abstract: Provided is a genetically modified non-human mammal that comprises an anchor DNA sequence inserted at an endogenous locus of a secretory milk protein gene, wherein the anchor DNA sequence comprises a site-specific recombinase recognition site. Also provided is a genetically modified non-human mammal that comprises a transgene inserted at an endogenous locus of a secretory milk protein gene, wherein the transgene encodes a secretory protein and is operably linked to the endogenous promoter of said secretory milk protein gene, and wherein the transgene is flanked by a pair of site-specific recombinase resulting sites. The genetically modified non-human mammals provided can be used for producing the secreted recombinant protein encoded by the transgene from the milk produced by the genetically modified non-human mammals.

Abstract: The present invention relates to nanoparticles complexed with therapeutic agents configured for treating cardiovascular related disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying therapeutic agents configured for treating cardiovascular related disorders, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutic agents, imaging agents, and/or targeting agents (e.g., in cardiovascular disease diagnosis and/or therapy, etc.))).

Abstract: A method of processing a cover page image of multimedia information, a client and an electronic device are provided. The method includes acquiring initial cover page images of N pieces of second multimedia information following first multimedia information, where the first multimedia information is displayed on a current display interface of the client, the N pieces of second multimedia information are not displayed on the current display interface of the client, and N is an integer greater than or equal to 1, performing a super-resolution processing on the initial cover page images of the N pieces of second multimedia information, to obtain super-resolution cover page images of the N pieces of second multimedia information, and displaying the super-resolution cover page images of the second multimedia information, in a case that the second multimedia information enters the current display interface.

Abstract: This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of sodium-glucose cotransporter (SGLT) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to cystic fibrosis (CF), comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents which function as inhibitors of SGLT activity.

Abstract: A method for logic design partitioning includes: collecting an RTL design file used for describing a logic circuit; performing syntax analysis processing on the RTL design file; extracting an always object and an assign object from logic model objects, and encapsulating the always object and the assign object, respectively; constructing and generating a hypergraph-based data structure; performing attribute analysis, and obtaining operating frequency information by processing according to clock domain information; associating and storing the clock domain information and the operating frequency information with corresponding nodes; and performing partitioning processing to obtain corresponding partitioned data. By means of the solutions of the present invention, other processing at the back end of the flow is not affected, the partitioning time is reduced and the partitioning efficiency is improved. Meanwhile, the logic content in chip design is partitioned efficiently, reasonably and correctly.

Abstract: The present disclosure provides a method of treating NAFLD, NASH, and atherosclerosis, comprising administering glycine-containing tripeptide molecule, or a pharmaceutically acceptable salt thereof to a subject.

Abstract: Provided herein is technology relating to molecular biological manipulation of genes and genomes and particularly, but not exclusively, to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) methods, compositions, systems, and kits for improved genetic editing.

Abstract: A method of processing a cover page image of multimedia information, a client and an electronic device are provided. The method includes: acquiring initial cover page images of N pieces of second multimedia information following first multimedia information, where the first multimedia information is displayed on a current display interface of the client, the N pieces of second multimedia information are not displayed on the current display interface of the client, and N is an integer greater than or equal to 1; performing a super-resolution processing on the initial cover page images of the N pieces of second multimedia information, to obtain super-resolution cover page images of the N pieces of second multimedia information; and displaying the super-resolution cover page images of the second multimedia information, in a case that the second multimedia information enters the current display interface.

Abstract: The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes- but is not limited to- liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.