Patents by Inventor JiJie Gu

JiJie Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION
    Publication number: 20080182845
    Abstract: Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.
    Type: Application
    Filed: November 16, 2007
    Publication date: July 31, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Philip Bardwell, Tariq Ghayur, Jijie Gu
  • Multiple Gene Expression including sORF Constructs and Methods with Polyproteins, Pro-Proteins, and Proteolysis
    Publication number: 20070065912
    Abstract: Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) contains polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest. The primary product can also contain cleavage sequences such as other proteolytic cleavage or protease recognition sites, or signal peptides which contain recognition sequences for signal peptidases, separating at least two of the multiple protein subunits. The sequences of the inserted auto-processing polypeptides or cleavage sites can be manipulated to enhance the efficiency of expression of the separate multiple protein subunits.
    Type: Application
    Filed: July 21, 2006
    Publication date: March 22, 2007
    Applicant: ABBOTT LABORATORIES
    Inventors: Gerald CARSON, Jochen SALFELD, Dean REGIER, Jijie GU, Wendy GION, Yune KUNES
  • Inhibition of p53 degradation
    Patent number: 6831155
    Abstract: The invention provides compositions and methods for inhibiting degradation of p53, thereby enhancing p53-mediated tumor suppressor activity.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: December 14, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Zhi-Min Yuan, JiJie Gu
  • Inhibition of P53 degradation
    Publication number: 20020132977
    Abstract: The invention provides compositions and methods for inhibiting degradation of p53, thereby enhancing p53-mediated tumor suppressor activity.
    Type: Application
    Filed: December 7, 2000
    Publication date: September 19, 2002
    Inventors: Zhi-Min Yuan, JiJie Gu