Patents by Inventor Jill Wilken

Jill Wilken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer-modified synthetic proteins
    Publication number: 20060233747
    Abstract: The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
    Type: Application
    Filed: June 5, 2006
    Publication date: October 19, 2006
    Applicant: Amylin Pharmaceuticals, Inc.
    Inventors: Gerd Kochendoerfer, Paolo Botti, James Bradburne, Shiah -yun Chen, Sonya Cressman, Christie Hunter, Stephen Kent, Donald Low, Jill Wilken
  • N-terminal modification of RANTES and methods of use
    Publication number: 20050208016
    Abstract: N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.
    Type: Application
    Filed: January 13, 2005
    Publication date: September 22, 2005
    Inventors: Robin Offord, Darren Thompson, Jill Wilken
  • N-terminal modifications of RANTES and methods of use
    Patent number: 6942852
    Abstract: N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: September 13, 2005
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Robin E. Offord, Darren Thompson, Jill Wilken
  • Polymer-modified bioactive synthetic chemokines, and methods for their manufacture and use
    Publication number: 20050089970
    Abstract: The invention relates to polymer-modified bioactive synthetic chemokines and to methods for their production and use. The bioactive synthetic chemokines of the invention comprises a polymer modified polypeptide chemokine backbone. The compounds and methods or the invention are useful for the treatment of disorders involving naturally occurring chemokines, such as for the treatment of HIV and AIDS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.
    Type: Application
    Filed: July 12, 2001
    Publication date: April 28, 2005
    Inventors: James Bradburne, Gerd Kochendoerfer, Jill Wilken
  • Modular protein libraries and methods of preparation
    Patent number: 6844161
    Abstract: Novel proteins and protein libraries are disclosed. The proteins possess one or more functional protein modules from different parent protein molecules. The proteins and protein libraries are exemplified by the preparation of cross-over chemokines that contain various combinations of peptide segments derived from RANTES, SDS-1 and vMIP-I and to vMIP-II. The proteins and libraries are extremely pure and can be provided in non-limiting high yields suitable for diagnostic and high-throughput screening assays.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: January 18, 2005
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Michael A. Siani, Jill Wilken, Reyna Simon, Stephen B. H. Kent
  • MODULAR PROTEIN LIBRARIES AND METHODS OF PREPARATION
    Publication number: 20020051996
    Abstract: Novel proteins and libraries comprising them are disclosed. The proteins comprise one or more functional protein modules from different parent protein molecules. The proteins and libraries are exemplified by the preparation of cross-over chemokines comprising various combinations of peptide segments derived from RANTES, SDF-1 and vMIP-I and vMIP-II. The proteins and libraries are extremely pure and can be provided in non-limiting high yields suitable for diagnostic and high-throughput screening assays.
    Type: Application
    Filed: August 31, 1998
    Publication date: May 2, 2002
    Inventors: MICHAEL A. SIANI, JILL WILKEN, REYNA SIMON, STEPHEN B.H. KENT
  • N-terminal modifications of RANTES and methods of use
    Patent number: 6168784
    Abstract: N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 2, 2001
    Assignee: Gryphon Sciences
    Inventors: Robin E. Offord, Darren Thompson, Jill Wilken