Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Aspects of the present invention relate to a method and to a control system for controlling an active suspension of a road vehicle comprising a vehicle body and a plurality of wheels, the control system comprising one or more controllers, the control system configured to: receive information indicative of a requirement for positive or negative vehicle acceleration in a first axis; and control the active suspension to commence modifying an angle of the vehicle body relative to the plurality of wheels about a second axis perpendicular to the first axis in dependence on the receiving an indication, before commencement of the vehicle acceleration.

Abstract: Aspects of the present invention relate to a method and to a control system for controlling an active suspension of a vehicle, the control system comprising one or more controllers, the control system configured to: obtain information indicative of a change of gradient of a driving surface in a direction of travel; and control the active suspension to adjust relative ride height between a front and rear of a vehicle body of the vehicle above the driving surface beneath the vehicle in dependence on the change of gradient.

Abstract: Aspects of the present invention relate to a method and to a control system for controlling an active suspension of a vehicle, the control system comprising one or more controllers, the control system configured to: receive information indicative of the vehicle becoming stationary; and increase a force of the active suspension in dependence on the receiving information indicative of the vehicle becoming stationary.

Abstract: Aspects of the present invention relate to a system for a vehicle comprising: a hydraulic suspension actuator comprising a piston, a first upper fluidic chamber and a second lower fluidic chamber, the first and second fluidic chambers separated by the piston; at least one actuator system module mounted to a subframe and laterally separated from the hydraulic suspension actuator, the at least one actuator system module comprising one or more actuator system components; a longitudinal beam located laterally between the hydraulic suspension actuator and the at least one actuator system module; and at least one conduit fluidly connecting the hydraulic suspension actuator and the at least one actuator system module, wherein the at least one conduit passes over the longitudinal beam.

Abstract: Aspects of the present invention relate to a method and to a control system for controlling an active suspension of a vehicle comprising a vehicle body and a plurality of wheels, the control system comprising one or more controllers, the control system configured to: receive information indicative of a requirement for ingress/egress of passengers and/or cargo; receive information indicative that the ingress/egress is to occur with the vehicle on a sloped surface; and control the active suspension to reduce an angle of the vehicle body relative to horizontal, for the ingress/egress on the sloped surface.

Abstract: Aspects of the present invention relate to a method and to a control system for controlling an active suspension of a vehicle, the control system comprising one or more controllers, the control system configured to: determine whether a transient suspension disturbance to the vehicle is from within a cabin of the vehicle; and control a variable force parameter of the active suspension in dependence on whether the transient suspension disturbance is from within the cabin of the vehicle.

Abstract: A container includes a plastics pressure vessel defining a hollow interior volume suitable for containing a quantity of a liquid, and comprising an inlet/outlet aperture extending through a wall thereof, and being in fluid communication with the hollow interior thereof. An insert, manufactured from a different, harder plastics material to that of the pressure vessel is provided within the inlet/outlet aperture, which is sealingly united (fused) with a periphery of the container to be securely retained therein. The plastics pressure vessel can be blow moulded around the insert so as to sealingly unite or fuse with the insert in the region of the interface between the different materials of which vessel and insert are formed. The insert may have a series of flats machined or otherwise formed around and into its outer circumferential surface so the insert is inhibited from axially or rotationally displacing relative to the pressure vessel.

Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).

Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).

Abstract: Integrated circuits and methods for producing the same are provided. A method for producing an integrated circuit includes forming an interconnect in a first interlayer dielectric. A first cap is formed overlying the first interlayer dielectric adjacent to the interconnect, and a second interlayer dielectric is formed overlying the first interlayer dielectric, the interconnect, and the cap. A contact is formed through the second interlayer dielectric, where the contact includes an overlap region and a connection region. The overlap region directly overlies the first interlayer dielectric adjacent to the interconnect, and the connection region directly contacts the interconnect. The first cap is positioned between the overlap region and the first interlayer dielectric.

Abstract: Integrated circuits and methods for producing the same are provided. A method for producing an integrated circuit includes forming an interconnect in a first interlayer dielectric. A first cap is formed overlying the first interlayer dielectric adjacent to the interconnect, and a second interlayer dielectric is formed overlying the first interlayer dielectric, the interconnect, and the cap. A contact is formed through the second interlayer dielectric, where the contact includes an overlap region and a connection region. The overlap region directly overlies the first interlayer dielectric adjacent to the interconnect, and the connection region directly contacts the interconnect. The first cap is positioned between the overlap region and the first interlayer dielectric.

Abstract: A support and a process for a non-automotive vehicle to be lifted by a car lift and allow for servicing of the vehicle. The support can include a support surface that has an engine access opening and a rolling mechanism attached to the support surface that affords for the support surface to roll into a service area that has a car lift. The car lift can be a two-post car and the support spans the distance between lift arms of the car lift. Once the support with a vehicle thereon is lifted above a service area floor vehicle, the engine of the vehicle can be serviced through the engine access opening. In this manner, non-automotive vehicles can be easily and quickly serviced in traditional automotive service areas, shops, etc.

Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.

Abstract: A support and a process for a non-automotive vehicle to be lifted by a car lift and allow for servicing of the vehicle. The support can include a support surface that has an engine access opening and a rolling mechanism attached to the support surface that affords for the support surface to roll into a service area that has a car lift. The car lift can be a two-post car and the support spans the distance between lift arms of the car lift. Once the support with a vehicle thereon is lifted above a service area floor vehicle, the engine of the vehicle can be serviced through the engine access opening. In this manner, non-automotive vehicles can be easily and quickly serviced in traditional automotive service areas, shops, etc.

Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).

Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.

Abstract: In a method of granting a user in a first organization access to private information within a second organization, the private information within the second organization is stored. An access agreement between the first and second organizations is formed, and the second organization stores the access agreement in an authorization profile. Authorization is requested for the user to access the private information within the second organization. The authorization profile is retrieved, and authorization for the user to access the private information within the second organization is granted if the access is authorized by the access agreement. In addition, in a method of authorizing access by users to private information stored by an organization as associated with a program, three types of caseloads are defined.

Abstract: A method and system is provided for searching for and licensing media content over a network.