Abstract: The present disclosures relates to a method of detecting, classifying, and counting dots in an image of a tissue specimen comprising detecting dots in an image of the tissue sample that meet criteria for absorbance strength, black unmixed image channel strength, red unmixed image channel strength, and a difference of Gaussian threshold, wherein the detected dots correspond to in situ hybridization signals in the tissue samples; classifying the detected dots as belonging to a black in situ hybridization signal or to a red in situ hybridization signal; and calculating a ratio of those dots belonging to the black in situ hybridization signal and those belonging to the red in situ hybridization signal.

Abstract: The present disclosure is directed to a computer system designed to (i) receive a series of images as input; (ii) compute a number of metrics derived from focus features and color separation features within the images; and (iii) evaluate the metrics to return (a) an identification of the most suitable z-layer in a z-stack, given a series of z-layer images in a z-stack; and/or (b) an identification of those image tiles that are more suitable for cellular based scoring by a medical professional, given a series of image tiles from an area of interest of a whole slide scan.

Abstract: The present disclosures relates to a method of detecting, classifying, and counting dots in an image of a tissue specimen comprising detecting dots in an image of the tissue sample that meet criteria for absorbance strength, black unmixed image channel strength, red unmixed image channel strength, and a difference of Gaussian threshold, wherein the detected dots correspond to in situ hybridization signals in the tissue samples; classifying the detected dots as belonging to a black in situ hybridization signal or to a red in situ hybridization signal; and calculating a ratio of those dots belonging to the black in situ hybridization signal and those belonging to the red in situ hybridization signal.

Abstract: The present disclosure is directed to a computer system designed to (i) receive a series of images as input; (ii) compute a number of metrics derived from focus features and color separation features within the images; and (iii) evaluate the metrics to return (a) an identification of the most suitable z-layer in a z-stack, given a series of z-layer images in a z-stack; and/or (b) an identification of those image tiles that are more suitable for cellular based scoring by a medical professional, given a series of image tiles from an area of interest of a whole slide scan.

Abstract: The subject disclosure provides systems and methods for determination of Area of Interest (AOI) for different types of input slides. Slide thumbnails may be assigned into one of five different types, and separate algorithms for AOI detection executed depending on the slide type. Slide types include ThinPrep (RTM) slides, tissue micro-array (TMA) slides, control HER2 slides with 4 cores, smear slides, and a generic slide. The slide type may be assigned based on a user input. Customized AOI detection operations are provided for each slide type. If the user enters an incorrect slide type, operations include detecting the incorrect input and executing the appropriate method. The result of each AOI detection operations provides as its output a soft-weighted image having zero intensity values at pixels that are detected as not belonging to tissue, and higher intensity values assigned to pixels detected as likely belonging to tissue regions.

Abstract: The present disclosure describes a method of foreground segmentation and nucleus ranking for scoring dual ISH images. The method has been developed to better identify those nuclei, within a selected field of view, that meet the criteria for dual ISH scoring.

Abstract: The present disclosures relates to a method of detecting, classifying, and counting dots in an image of a tissue specimen comprising detecting dots in an image of the tissue sample that meet criteria for absorbance strength, black unmixed image channel strength, red unmixed image channel strength, and a difference of Gaussian threshold, wherein the detected dots correspond to in situ hybridization signals in the tissue samples; classifying the detected dots as belonging to a black in situ hybridization signal or to a red in situ hybridization signal; and calculating a ratio of those dots belonging to the black in situ hybridization signal and those belonging to the red in situ hybridization signal.

Abstract: The present disclosure is directed to a computer system designed to (i) receive a series of images as input; (ii) compute a number of metrics derived from focus features and color separation features within the images; and (iii) evaluate the metrics to return (a) an identification of the most suitable z-layer in a z-stack, given a series of z-layer images in a z-stack; and/or (b) an identification of those image tiles that are more suitable for cellular based scoring by a medical professional, given a series of image tiles from an area of interest of a whole slide scan.

Abstract: This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.

Abstract: A gate latch for use with a gate may include a first handle to operate the gate latch from a first side of the gate and a second handle to operate the gate latch from a second side of the gate.

Abstract: A gate latch for use with a gate may include a first handle to operate the gate latch from a first side of the gate and a second handle to operate the gate latch from a second side of the gate.

Abstract: A method and system for distributing labor based upon determinations of traffic in a facility, such as a store. Daily traffic forecast information is obtained for each day within a given time period from a source of such information. Calendar and event information for the facility for each day within the given time period is determined. Baseline days are selected from historical traffic data, and baseline averages and percentages for a predetermined time interval are also selected. The distribution of traffic for each day within the given time period at each time interval is determined using the baseline percentages for each time interval. Labor data is distributed. Labor recommendations are provided at each time interval for the given time period based on the distribution of traffic for each day, and at least one of other user-defined workforce requirements. The results of any or all of these steps are displayed to a user.

Abstract: A method and system for distributing labor based upon determinations of traffic in a facility, such as a store. Daily traffic forecast information is obtained for each day within a given time period from a source of such information. Calendar and event information for the facility for each day within the given time period is determined. Baseline days are selected from historical traffic data, and baseline averages and percentages for a predetermined time interval are also selected. The distribution of traffic for each day within the given time period at each time interval is determined using the baseline percentages for each time interval. Labor data is distributed. Labor recommendations are provided at each time interval for the given time period based on the distribution of traffic for each day, and at least one of other user-defined workforce requirements. The results of any or all the these steps are displayed to a user.

Abstract: A disposable toilet seat cover designed to provide sanitary protection and support for smaller children when using public toilet seats of divided construction. The cover includes two sheets of thin flexible moisture resistant material laminated together to form an internal envelope inside the seat cover and that allows the cover to be easily slipped over a toilet seat thereby encapsulating the seat while providing a sanitary barrier that prevents human contact with unsanitary toilet surfaces. The cover further forms a seating area that when installed over a toilet seat maintains sufficient tension between the two curved side parts of the toilet seat to provide the support needed to prevent smaller children from falling through the larger opening in public toilet seats. A removal tab is provided in the front of the disposable toilet seat cover allowing for easy removal and discarding into the trash.

Abstract: A method and system for distributing labor based upon determinations of traffic in a facility, such as a store. Daily traffic forecast information is obtained for each day within a given time period from a source of such information. Calendar and event information for the facility for each day within the given time period is determined. Baseline days are selected from historical traffic data, and baseline averages and percentages for a predetermined time interval are also selected. The distribution of traffic for each day within the given time period at each time interval is determined using the baseline percentages for each time interval. Labor data is distributed. Labor recommendations are provided at each time interval for the given time period based on the distribution of traffic for each day, and at least one of other user-defined workforce requirements. The results of any or all the these steps are displayed to a user.

Abstract: A handle for an electronic instrument housing includes an elongated grip portion. The grip portion includes two elongated elements each having opposed ends. The elements are connected to each other to form an elongated chamber. An elastomeric layer encompasses an intermediate portion of the grip portion, and the grip portion has a vent aperture communicating with the chamber. The vent aperture may be beyond the elastomeric layer, at one or both ends. One of the elongated elements may form a channel with tapered edge surfaces receiving the other element, so that pressure of elastomeric molding tends to wedge the parts together to form a seal against incursion of the elastomer.

Abstract: An attachable/detachable variable spacing probing tip system has a housing that receives pivoting probing arms. Each probing arm has a support member and a probing arm portion of a flexible substrate having a conductive trace thereon. One end of each conductive trace is coupled to a probing contact and the other end coupled to an electrical contact pad on a electrical contact pad portion of the flexible substrate. Each of the probing arm portions has a generally S-shaped fold therein extending from the support members to the electrical contact portion of the flexible substrate. The housing includes means for pivoting the probing arms. The rear surface of the housing has a resilient member disposed therein. Latching means in the housing secures the electrical contact pad portion of the flexible substrate to the rear surface of the housing. Opposing attachment arms from a rear surface of the housing.

Abstract: A attachable/detachable probing tip system has a housing that includes a probing tip mounting member and opposing substantially orthogonal attachment arms extending from the probing tip mounting member. The attachment arms define an inner surface of the probing tip mounting member in which is disposed at least a first a non-compressive set, resilient member. First and second probing tips are disposed over the non-compressive, resilient member and secured to the housing by latching means. The attachable/detachable probing tip system allows mounting of the probing tips to probing contacts on a device under test without a measurement probe being attached. The attachment arms allows a measurement probe to be attached and detached to the probing tip system.

Abstract: A method and apparatus are provided for adjusting a content of an oral presentation provided by an agent of an organization and perceived by a human target of the organization based upon an objective of the organization. The method includes the steps of detecting a content of the oral presentation provided by the agent and modifying the oral presentation provided by the agent to produce the oral presentation perceived by the human target based upon the detected content and the organizational objective.