Abstract: Provided herein are methods, compositions and uses involving T cell therapies, such as adoptive T cell therapy, and an inhibitor of a Diacylglycerol kinase (DGK). The provided methods, compositions and uses include those involving the administration or use of one or more DGK inhibitors (DGKi) in a combination therapy with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR) or T cell receptor (TCR).

Abstract: In response to a user access request, a media object containing a plurality of media components is constructed and transmitted to the user. At least one of the media components has been categorized as having different degrees of relevance to humans from a first culture/geographical location and humans from a second culture/geographical location. The user is prompted to solve a puzzle by selecting one or more of the media components or rearranging a location, size, appearance, or orientation of one or more of the media components. A description of an action performed by the user in response to the prompting is obtained. A determination is made, based on the obtained description of the action performed by the user, whether the user is more likely to be a human from the first culture/geographical location or a machine or a human from outside the first culture/geographical location.

Abstract: In response to a user access request, a media object containing a plurality of media components is constructed and transmitted to the user. At least one of the media components has been categorized as having different degrees of relevance to humans from a first culture/geographical location and humans from a second culture/geographical location. The user is prompted to solve a puzzle by selecting one or more of the media components or rearranging a location, size, appearance, or orientation of one or more of the media components. A description of an action performed by the user in response to the prompting is obtained. A determination is made, based on the obtained description of the action performed by the user, whether the user is more likely to be a human from the first culture/geographical location or a machine or a human from outside the first culture/geographical location.

Abstract: In response to a user access request, a media object containing a plurality of media components is constructed and transmitted to the user. At least one of the media components has been categorized as having different degrees of relevance to humans from a first culture/geographical location and humans from a second culture/geographical location. The user is prompted to solve a puzzle by selecting one or more of the media components or rearranging a location, size, appearance, or orientation of one or more of the media components. A description of an action performed by the user in response to the prompting is obtained. A determination is made, based on the obtained description of the action performed by the user, whether the user is more likely to be a human from the first culture/geographical location or a machine or a human from outside the first culture/geographical location.

Abstract: In response to a user access request, a media object containing a plurality of media components is constructed and transmitted to the user. At least one of the media components has been categorized as having different degrees of relevance to humans from a first culture/geographical location and humans from a second culture/geographical location. The user is prompted to solve a puzzle by selecting one or more of the media components or rearranging a location, size, appearance, or orientation of one or more of the media components. A description of an action performed by the user in response to the prompting is obtained. A determination is made, based on the obtained description of the action performed by the user, whether the user is more likely to be a human from the first culture/geographical location or a machine or a human from outside the first culture/geographical location.

Abstract: The present disclosure involves a method. The method includes receiving a request from a user. The method includes constructing, by a computer processor, a media object that contains a plurality of media components. The method includes transmitting the media object to the user. The method includes prompting the user to perform a task involving at least a subset of the media components, the task including at least one of the following: selecting each of the media components in the subset according to a predefined sequence; and modifying at least one of the media components in the subset with respect to at least one of its following properties: location, size, appearance, and orientation. The method includes obtaining a description of an action performed by the user in response to the prompting. The method includes deciding whether or not to grant the request based on the obtaining.

Abstract: A cuff device comprising an elongated body, a flexible cable within the body, a loop extraction system for extracting a loop of the cable from an end of the elongated body large enough to fit over an extremity of a suspect, and a loop retraction system for retracting the loop to fit snugly over the extremity. A second cable is preferred, with one cable deployed from each end of the elongated body, preferably a PR-24 form factor baton.

Abstract: A cuff device comprising an elongated body, a flexible cable within the body, a loop extraction system for extracting a loop of the cable from an end of the elongated body large enough to fit over an extremity of a suspect, and a loop retraction system for retracting the loop to fit snugly over the extremity. A second cable is preferred, with one cable deployed from each end of the elongated body, preferably a PR-24 form factor baton.