Abstract: Method and systems for ablating nerves including measurement of physiological parameters and/or electrical conduction. The method may include ablating nerves within an artery of a patient such as the renal artery and may include advancing a catheter into the artery, measuring a physiological parameter, emitting an electrical pulse into a wall of the artery, measuring the physiological parameter during or after the step of emitting the electrical pulse, ablating the artery wall, then repeating the steps of measuring the physiological parameter, emitting an electrical pulse, and measuring the physiological parameter during or after the step of emitting the electrical pulse. The change in the physiological parameter caused by the electrical pulse before ablation may be compared to the change in the physiological parameter caused by the electrical pulse after ablation to determine the degree of nerve ablation achieved and whether or not to perform further ablation.

Abstract: Various aspects of the present disclosure are directed toward an implantable electrostimulation device, a plurality of sensing and pacing elements, and a fine wire lead extending in a sealed relationship from the electrostimulation device and to the plurality of sensing and pacing elements. The fine wire lead includes multiple discrete conductors and a drawn silica or glass fiber core, a polymer cladding on the drawn silica or glass fiber core, and a conductive metal cladding over the polymer cladding. Additionally, the fine wire lead simultaneously delivers different electrical signals or optical signals between the sensing and pacing elements and the electrostimulation device.

Abstract: A system and method for retrieving an implantable device includes a delivery catheter, a recapture section, and a sheath. The delivery catheter has a proximal end and a distal end. The recapture section is axially extendable from the distal end of the delivery catheter. The sheath has a proximal end and a distal end and a lumen sized to receive the delivery catheter. A portion of the lumen of the sheath is actuatable from an enlarged inside diameter to a reduced inside diameter to apply an inwardly directed force to the recapture section. The delivery catheter can be actuated with respect to the sheath to extend or retract the recapture section with respect to the delivery catheter.

Abstract: Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

Abstract: Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.

Abstract: Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications.

Abstract: A small diameter, shielded, fine wire glass fiber conductor which is capable of transmitting optical and electrical signals in environments with electromagnetic interference or radio frequency interferences. The conductor includes a fiber core, a first insulation layer, a conductive layer, a second insulation layer, a shielding layer, and an outer coating. Applications include use in aerospace, automotive, and other vehicles as well as potential use in electrostimulation devices, such as pacemaker leads, vascular guidewires and other medical applications.

Abstract: Methods, systems, and devices for ablating nerves within an artery. The method includes selecting an ablation device having an outer guiding catheter and an inner treatment catheter including an expandable element and an ablative element on the expandable element. The ablation device is selected such that the expandable element is sized to apply an outward force against a portion of the inner wall of the artery substantially sufficient to hold the artery open during an arterial spasm event. The method can include advancing the ablation device to the treatment location, positioning the treatment catheter out of the guiding catheter, expanding the expandable element such that after expansion the expandable element applies the outward force against the portion of the inner wall of the artery, and ablating the inner wall of the artery using the ablation element after expanding the expandable element and without moving the treatment catheter.

Abstract: A cardiac pacemaker or other implantable electrostimulation device has one or more durable fine wire leads to the heart or other electrostimulation site. The lead is formed of a core of silica or glass fiber or similar material, with a protective coating preferably including a metal buffer for conduction. The lead can be unipolar or bipolar (or even with three or more conductors), of small diameter and preferably with an anchoring configuration at the distal end of the lead. The anchor feature can take any of several nonlinear forms such that once implanted in a constrained configuration, the anchor can be released to the expanded, nonlinear configuration. The electrostimulation leads of the invention are extremely durable, can be bent through small radii and can exhibit long life without fatigue failure.

Abstract: Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.

Abstract: A method for accessing the left atrial appendage with a balloon-tipped transseptal sheath is disclosed. A transseptal sheath is delivered to the left atrium through the intraatrial septum from the right atrium. The balloon tip may be inflated to prevent the transseptal sheath from falling proximally into the right atrium. The inflated balloon tip permits safe probing and exploration of the left atrial appendage and facilitates safe maintenance of the position of the transseptal sheath within the left atrial appendage while delivering an implantable device to the left atrial appendage.

Abstract: A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a thin metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The thin metal conductor poses unique challenges for attachment to standardized connectors as well as to stimulation electrodes. This invention describes structures and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes by utilization of fine metal coils or mesh and electrically conductive adapters to aid in stabilizing the connections.

Abstract: Method and systems for ablating nerves including measurement of physiological parameters and/or electrical conduction. The method may include ablating nerves within an artery of a patient such as the renal artery and may include advancing a catheter into the artery, measuring a physiological parameter, emitting an electrical pulse into a wall of the artery, measuring the physiological parameter during or after the step of emitting the electrical pulse, ablating the artery wall, then repeating the steps of measuring the physiological parameter, emitting an electrical pulse, and measuring the physiological parameter during or after the step of emitting the electrical pulse. The change in the physiological parameter caused by the electrical pulse before ablation may be compared to the change in the physiological parameter caused by the electrical pulse after ablation to determine the degree of nerve ablation achieved and whether or not to perform further ablation.

Abstract: A method for accessing the left atrial appendage with a balloon-tipped transseptal sheath is disclosed. A transseptal sheath is delivered to the left atrium through the intraatrial septum from the right atrium. The balloon tip may be inflated to prevent the transseptal sheath from falling proximally into the right atrium. The inflated balloon tip permits safe probing and exploration of the left atrial appendage and facilitates safe maintenance of the position of the transseptal sheath within the left atrial appendage while delivering an implantable device to the left atrial appendage.

Abstract: A method for accessing the left atrial appendage with a balloon-tipped transseptal sheath is disclosed. A transseptal sheath is delivered to the left atrium through the intraatrial septum from the right atrium. The balloon tip may be inflated to prevent the transseptal sheath from falling proximally into the right atrium. The inflated balloon tip permits safe probing and exploration of the left atrial appendage and facilitates safe maintenance of the position of the transseptal sheath within the left atrial appendage while delivering an implantable device to the left atrial appendage.

Abstract: A system and method for retrieving an implantable device includes a delivery catheter, a recapture section, and a sheath. The delivery catheter has a proximal end and a distal end. The recapture section is axially extendable from the distal end of the delivery catheter. The sheath has a proximal end and a distal end and a lumen sized to receive the delivery catheter. A portion of the lumen of the sheath is actuatable from an enlarged inside diameter to a reduced inside diameter to apply an inwardly directed force to the recapture section. The delivery catheter can be actuated with respect to the sheath to extend or retract the recapture section with respect to the delivery catheter.

Abstract: A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a thin metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The thin metal conductor poses unique challenges for attachment to standardized connectors as well as to stimulation electrodes. This invention describes structures and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes by utilization of fine metal coils or mesh and electrically conductive adapters to aid in stabilizing the connections.

Abstract: Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications.

Abstract: Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.

Abstract: A system and method for retrieving an implantable device includes a delivery catheter, a recapture section, and a sheath. The delivery catheter has a proximal end and a distal end. The recapture section is axially extendable from the distal end of the delivery catheter. The sheath has a proximal end and a distal end and a lumen sized to receive the delivery catheter. A portion of the lumen of the sheath is actuatable from an enlarged inside diameter to a reduced inside diameter to apply an inwardly directed force to the recapture section. The delivery catheter can be actuated with respect to the sheath to extend or retract the recapture section with respect to the delivery catheter.