Abstract: The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Abstract: Disclosed are an abietane type diterpene compound, a preparation method and an application thereof, relating to the technical field of anti-tumor compounds, where the compound has a chemical structure as shown in the following formula I: Leucosceptrum canum is extracted to prepare the abietane type diterpene compound according to the present application, and the prepared compound is effectively applied in inhibiting human lung cancer cell A549 and human myeloid leukemia cell HL-60.

Abstract: Disclosed are a control method and apparatus for safety boot of a chip, an electronic device and a storage medium. The method includes: determining, at a preset stage of a chip boot process, first mirror data to be checked at the preset stage and first check code corresponding to the first mirror data, from a decryption result obtained by a hardware security module; determining second check code based on the first mirror data; comparing the second check code with the first check code to obtain a comparison result; determining an integrity check result of the first mirror data based on the comparison result; and executing, based on the integrity check result, a safety boot program corresponding to the first mirror data at the preset stage.

Abstract: Disclosed are an abietane type diterpene compound, a preparation method and an application thereof, relating to the technical field of anti-tumor compounds, where the compound has a chemical structure as shown in the following formula I: Leucosceptrum canum is extracted to prepare the abietane type diterpene compound according to the present application, and the prepared compound is effectively applied in inhibiting human lung cancer cell A549 and human myeloid leukemia cell HL-60.

Abstract: Provided is a light-emitting panel comprising a substrate, a plurality of light-emitting device, and a reflection sheet, wherein the plurality of light-emitting devices and the reflection sheet are disposed on the same side of the substrate, the reflection sheet comprises a plurality of first through-holes, which are in one-to-one correspondence with the plurality of light-emitting devices, and the reflection sheet at an edge of the plurality of first through-holes is configured to wrap around an edge of the plurality of light-emitting device, and a gap between an edge of the plurality of first through-holes and an edge adjacent to the plurality of light-emitting devices is less than 0.1 mm, so that a distance between the edge of the plurality of first through holes and the edge of the plurality of light-emitting devices is reduced, and the size and width of the windowed area are reduced.

Abstract: A paper lipstick tube with threads, including a lipstick tube body which includes an A lipstick tubing, a B lipstick tubing, a C lipstick tubing, a pin, a D lipstick tubing, an F lipstick tubing, an M lipstick tubing, a K lipstick tubing, a cover tube H, a circular gasket and cream. The B lipstick tubing is rotatably installed inside the F lipstick tubing. The lipstick tube body is a container with a push-pull function made of only paper and a small amount of natural bamboo or wood materials. Through mutual rotation of the F lipstick tubing and the B lipstick tubing, upward and downward shearing forces are applied to the pin spirally through the threaded groove in the B lipstick tubing. At the same time, the pin is also in up-and-down guide openings of the D lipstick tubing, so that the C lipstick tubing can only move up and down.

Abstract: The present disclosure provides a power semiconductor device and a manufacturing method thereof. In order to provide a power semiconductor device with improved latch-up immunity but without increasing device power loss and costs, a hole current path in a fourth semiconductor region of a first conductivity type between a gate trench and a dummy gate trench is shortened by providing a first contact trench between two adjacent gate trenches, and providing a second contact trench between the gate trench and a dummy gate trench such that the width and depth of the second contact trench are respectively greater than those of the first contact trench. The effect of the hole current on the potential rise of the fourth semiconductor region of the first conductivity type is suppressed, thereby suppressing the latch-up effect, and enhancing the switching reliability.

Abstract: The present disclosure discloses a method for extracting a plant essential oil with dual auxiliaries, which includes: using an aromatic plant as a raw material, adding an extracting liquid prepared from the dual auxiliaries and water, stirring evenly for raw material wetting back, then distilling and collecting the essential oil, where the dual auxiliaries include a component A and a component B, the component A includes at least one of choline chloride and betaine, and the component B includes at least one of a natural acid, an amine, an alcohol and a saccharide.

Abstract: Introduced here are computer programs and computer-implemented techniques for discovering malicious emails and then remediating the threat posed by those malicious emails in an automated manner. A threat detection platform may monitor a mailbox to which employees of an enterprise are able to forward emails deemed to be suspicious for analysis. This mailbox may be referred to as an “abuse mailbox” or “phishing mailbox.” The threat detection platform can examine emails contained in the abuse mailbox and then determine whether any of those emails represent threats to the security of the enterprise. For example, the threat detection platform may classify each email contained in the abuse mailbox as being malicious or non-malicious. Thereafter, the threat detection platform may determine what remediation actions, if any, are appropriate for addressing the threat posed by those emails determined to be malicious.

Abstract: The present disclosure provides a gene combination for expressing and producing terrequinone A in Escherichia coli and use thereof. The gene combination includes a tdiAS gene, a tdiBS gene, a tdiCS gene, a tdiDS gene, a tdiES gene, an sfpS gene, an ScCKS gene, and an AtIPKS gene with nucleotide sequences set forth in SEQ ID NOS:1 to 8. In the present disclosure, a recombinant engineered strain capable of producing terrequinone A having anti-cancer activity is obtained by separately constructing recombinant plasmids pC02 and pU03 through the eight genes and transforming the two recombinant plasmids into E. coli. The content of terrequinone A in a fermentation broth thereof is 106.3 mg/L, which has potential application value in the biopharmaceutical field.

Abstract: The present disclosure features compounds and methods useful for the treatment of BAF complex-related disorders.

Abstract: A method, system, and computer program product for script generation and recommendation from behavior trees are provided. The method receives a set of input commands within a programming interface. The set of input commands is parsed into a set of command parts. The set of input commands is normalized based on the set of command parts to generate a set of normalized commands. A set of behavior trees are generated based on the set of normalized commands and the set of parts. The method generates a set of command scripts based on the set of behavior trees.

Abstract: Selectively rewriting URLs is disclosed. An indication is received that a message has arrived at a user message box. A determination is made that the message includes a first link to a first resource. The first link is analyzed to determine whether the first link is classified as a non-rewrite link. In response to determining that the first link is not classified as a non-rewrite link, a first replacement link is generated for the first link.

Abstract: A display panel is provided, including a grounding signal wiring, driving chips, a driving chip input output signal wiring, and a power line. A grounding signal pin is connected to the grounding signal wiring. The driving chip input output signal wiring is configured to connect a stage-transfer signal input pin and a stage-transfer signal output pin of two adjacent driving chips. The grounding signal wiring, the driving chip input output signal wiring, and the power line are disposed in a same layer and do not intersect with each other.

Abstract: Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Abstract: Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

Abstract: The present disclosure features compounds and methods useful for the treatment of BAF complex-related disorders.

Abstract: Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

Abstract: Provided are a human IL-15 molecule mutant and a fusion protein containing the IL-15 mutant and combined mutations, wherein the fusion protein can mediate the activation and amplification of immune cells and can be used for treating tumor disease