Abstract: Disclosed herein are methods for detecting the presence of transthyretin monomers in a subject sample.

Abstract: The present invention provides a polypeptide derivative, or a modified derivative or salt thereof, and use of the polypeptide derivative, or the modified derivative or salt thereof. The polypeptide derivative, or the modified derivative or salt thereof comprises a polypeptide having the sequence of the following general formula I: general formula I: HX2QGTFTSDX10SKYLX15EX17X18AX20X21FX23AWLEX28X29X30, wherein the definitions of X2, X10, X15, X17, X18, X20, X21, X23, X28, X29, and X30 are consistent with those in the claims and description. The polypeptide derivatives of the present invention are dual agonists for GC/GLP-1 receptor, have a synergic effect on energy metabolism, can effectively reduce weight and improve a body fat level while reducing blood glucose, and have a potential application value in the field of treatment of metabolic diseases such as diabetes and obesity.

Abstract: A molecular imaging agent including a detectable moiety, a chelation moiety, and a carrier moiety is provided. In one embodiment, the detectable moiety is coupled to the chelation moiety and the chelation moiety is linked to the carrier moiety. In another embodiment, the detectable moiety is 99mTc; the chelation moiety includes HYNIC; and the carrier moiety includes from N-terminus to C-terminus: a His6 purification tag, a human VEGFA polybasic tag sequence, and a human Fc stabilization segment.

Abstract: A solid-state hydrophone may include a piezoelectric rod positioned between at least two electrodes. The piezoelectric rod may be disposed within a metallic housing to shield the piezoelectric rod and its connections from acoustic and electromagnetic waves. The piezoelectric rod and the electrodes may be potted in the mechanical housing using a potting material that may be positioned adjacent to the piezoelectric rod. At least a layer of the potting material may be positioned between the piezoelectric rod and the metallic housing to physically separate the piezoelectric rod from the metallic housing.

Abstract: An acoustic isolator and methods to the same. The acoustic isolator may comprise a body, one or more annular chambers formed inside the body of the acoustic isolator and positioned along a longitudinal axis of the acoustic isolator, an annular groove formed on an outer surface of the body of the acoustic isolator, and a passage disposed between the one or more annular chambers and the annular groove. The method may comprise transmitting an acoustic wave from a transmitter disposed on an acoustic logging tool into a subterranean formation, receiving an acoustic signal from the subterranean formation with a receiver disposed on the acoustic logging tool, and attenuating a second acoustic wave that moves between the transmitter and the receiver and through an acoustic isolator.

Abstract: A method for identifying a leak for dynamic logging may comprise estimating a Stoneley wave slowness, separating a Stoneley wave into an up-going Stoneley wave and a down-going Stoneley wave, estimating an amplitude of the up-going Stoneley wave and the down-going Stoneley wave, identifying a difference between the amplitude of the up-going Stoneley wave and the down-going Stoneley wave, forming an amplitude summation curve or an amplitude difference curve, and identifying a location of the leak.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: The disclosure relates to methods of enhancing aqueous humor out-flow via the conventional outflow tract in the eye in a subject in need thereof, or reducing intraocular pressure in a subject in need thereof.

Abstract: An acoustic transducer includes a substrate element having a first side, and a second side opposite the first side. The acoustic transducer also includes first and second piezoelectric elements coupled to the first side, and third and fourth piezoelectric elements coupled to the second side. The first piezoelectric element has a first polarity, and the second piezoelectric element has a second polarity different than the first polarity. The third piezoelectric element has a third polarity, and the fourth piezoelectric element has a fourth polarity different than the third polarity.

Abstract: The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.

Abstract: The disclosure relates to Angiopoietin-1 mimetics for treating vascular diseases via agonistic activation of Tie2/TEK receptor.

Abstract: A biometric verification system is disclosed. The system includes a portable device which stores a biometric reference template and authentication preferences, The portable device can be used with an access device. The access device can prompt the user for a biometric sample, The access device may create a biometric sample template from the biometric sample, and the biometric sample template can be compared to the biometric reference template to determine if a user is authentic.

Abstract: The disclosure provides an electromagnetic device design system including: one or more processors of a machine; and computer-storage medium storing instructions, which when executed by the machine, cause the machine to perform operations for EM sensitivity analysis for an electromagnetic (EM) device. The operations include: initiating physical parameters of the EM device, wherein the EM device comprises multiple ports; performing EM simulation for the EM device at a pre-solution frequency using the finite-element method (FEM); applying single-size matrix Padé via Lanczos (MPVL) method in fast frequency sweep and performing EM simulation for the EM device under excitation at each port to obtain field solution of the EM device at frequencies in a frequency range; calculating S-parameters for the multiple ports of the EM device; and calculating derivatives of the S-parameters with respect to one of the physical parameters in the frequency range.

Abstract: The disclosure provides an acoustic logging device comprising a first tubular member comprising a plurality of grooves disposed on an exterior of the first tubular member. The acoustic logging device further comprises a ring transmitter module disposed around an exterior of the first tubular member, which comprises a piezoelectric (PZT) ring transmitter, a transmitter sleeve, wherein the PZT ring transmitter is disposed within the transmitter sleeve, and a cage, wherein the transmitter sleeve is disposed between the cage and the exterior of the first tubular member, wherein the transmitter sleeve is disposed over the plurality of grooves. The acoustic logging device further comprises a plurality of dual bender transmitters, wherein there is a gap disposed the plurality of dual bender transmitters in the exterior of the first tubular member, wherein there is an array of holes connecting each of the gaps together and providing fluid communication between the gaps.

Abstract: A sensor system may be used to measure characteristics of an object in a wellbore. The sensor system may include an ultrasonic transducer that generates an ultrasonic wave in a medium of the wellbore and detects a reflection signal of the ultrasonic wave off the object in the wellbore. The sensor system may also include a processing device and a memory device in which instructions are stored. The memory may include instructions that cause the processing device to receive the reflection signal from the ultrasonic transducer, and to truncate and preprocess the reflection signal to generate a truncated reflection signal. The instructions may also cause the processing device to apply time gain compensation to the truncated reflection signal and determine an echo wavelet from the time gain compensated signal representing an echo of the ultrasonic wave off of a wall of the wellbore.

Abstract: This invention provides a system-oriented and fully-controlled connected automated vehicle highway system for various levels of connected and automated vehicles and highways. The system comprises one or more of: 1) a hierarchical traffic control network of Traffic Control Centers (TCC's), local traffic controller units (TCUs), 2) A RSU (Road Side Unit) network (with integrated functionalities of vehicle sensors, I2V communication to deliver control instructions), 3) OBU (On-Board Unit with sensor and V2I communication units) network embedded in connected and automated vehicles, and 4) wireless communication and security system with local and global connectivity. This system provides a safer, more reliable and more cost-effective solution by redistributing vehicle driving tasks to the hierarchical traffic control network and RSU network.

Abstract: An apparatus and system for deploying an acoustic sensor are disclosed. In some embodiments, an acoustic sensor includes a transducer comprising a piezoelectric material layer having a front side from which the transducer is configured to transmit acoustic sensing signals and an opposing back side. A backing material layer comprising an acoustic damping material is coupled at a front side to the back side of the piezoelectric material layer. An acoustic reflector such as may comprise a cavity containing gaseous or liquid fluid is disposed between the front side and a back side of the backing material layer.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: This invention provides a system-oriented and fully-controlled connected automated vehicle highway system for various levels of connected and automated vehicles and highways. The system comprises one or more of: 1) a hierarchical traffic control network of Traffic Control Centers (TCC's), local traffic controller units (TCUs), 2) A RSU (Road Side Unit) network (with integrated functionalities of vehicle sensors, I2V communication to deliver control instructions), 3) OBU (On-Board Unit with sensor and V2I communication units) network embedded in connected and automated vehicles, and 4) wireless communication and security system with local and global connectivity. This system provides a safer, more reliable and more cost-effective solution by redistributing vehicle driving tasks to the hierarchical traffic control network and RSU network.