Patents by Inventor Jing Xiong
Jing Xiong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240116941Abstract: Disclosed are novel solid forms of compound (I), (3-[(8aS)-7-[[(4S)-5-ethoxycarbonyl-4-(3-fluoro-2-methyl-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid), and pharmaceutical compositions comprising solid forms thereof having characteristics described herein, which can be used as a HBV capsid inhibitor (or HBV Core Protein Allosteric Modifier), or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.Type: ApplicationFiled: December 14, 2023Publication date: April 11, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Jing Xiong, Xuemei Wang
-
Patent number: 11873302Abstract: The present invention relates to novel solid forms of compound (I), 3-[(8aS)-7-[[(4S)-5-ethoxycarbonyl-4-(3-fluoro-2-methyl-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid and pharmaceutical compositions comprising solid forms thereof disclosed herein, which can be used as a HBV capsid inhibitor (or HBV Core Protein Allosteric Modifier), or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.Type: GrantFiled: March 24, 2020Date of Patent: January 16, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Jing Xiong, Xuemei Wang
-
Patent number: 11866459Abstract: The present invention relates to a cocrystal of progesterone, which is formed by the active ingredient progesterone and a cocrystal former which is selected from isophthalic acid, 4-formylbenzeneboronic acid and 3-nitrophthalic acid. The present invention also relates to the method for preparing the cocrystal of progesterone and use thereof for increasing the thickness of endometrium, improving progesterone's solubility or increasing progesterone's permeation rate.Type: GrantFiled: March 4, 2021Date of Patent: January 9, 2024Assignee: NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROLInventors: Lan He, Jing Xiong, Xiangxiang Wu, Xin Zhu, Zhonglin Lu, Yan Shi, Na Zhang, Yang Liu
-
Publication number: 20230399297Abstract: The invention relates to novel glutamine analogs, a composition containing the glutamine analogs and the use thereof.Type: ApplicationFiled: October 14, 2021Publication date: December 14, 2023Inventors: Runze LI, Cunbo MA, Zhenchang LIAN, Jing XIONG, Yanping WANG, Wei LONG
-
Publication number: 20230173990Abstract: A pickup truck rack includes a fastening base, a support frame, a fastening rod, and a fastening frame. There are two fastening bases. One support frame is fastened on each of upper ends of the two fastening bases. Rail grooves are provided at both an upper end and a lower end of the fastening rod. The fastening frame and two support frames are respectively disposed at the upper end and lower end of the fastening rod and are reciprocable or fixable along the corresponding rail grooves. The support frame is a retractable support frame formed by an inner tube and an outer tube that are sleeved. A vertical sliding groove is opened on the inner tube. A clip is provided inside the sliding groove. A bolt through hole is provided at an upper end of the outer tube.Type: ApplicationFiled: February 15, 2022Publication date: June 8, 2023Inventors: Xiaojun NI, Chengsheng FANG, Jing XIONG, Yongjin XU
-
Publication number: 20230100638Abstract: A soft-bodied apparatus and a method for opening an eyelid are provided. The apparatus includes: a head support module, a real-time eyelid positioning module, a robot end-effector real-time positioning module, and an automatic eyelid opening operation module. The automatic eyelid opening operation module includes a robot body and a robot control system. The robot body is provided with a multi-axis rigid body mechanical arm and a soft-bodied end-effector. The robot control system takes the real-time poses of the upper and lower eyelids of the user as a motion target, and takes the real-time shape and the pose of the soft-bodied end-effector as feedback information to control motion of the robot body to automatically open the eyelid.Type: ApplicationFiled: February 5, 2021Publication date: March 30, 2023Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCESInventors: Zeyang XIA, Yangzhou GAN, Hao DENG, Jing XIONG
-
Patent number: 11548446Abstract: A vehicle rack includes two cross beams, the cross beams being hollow square rods parallelly placed, the bottom center of the cross beam being provided with a sliding slot along the beams; two fixing rods, the fixing rods being hollow and each including an H-shaped reinforcing seat, the H-shaped reinforcing seat forming an upper sliding slot I on a top surface of the fixing rod and forming a lower sliding slot I on a bottom surface of the fixing rod, the fixing rods being particular to the two cross beams; a plurality of connecting seat, the connecting seats movably connecting the cross beams and the fixing rods, the connecting seats including upper bolt connecting parts; a plurality of supporting frames, the fixing rods each connecting two supporting frames, the supporting frames including lower bolt connecting parts.Type: GrantFiled: February 3, 2020Date of Patent: January 10, 2023Assignee: FORCOME (ZHEJIANG) CO., LTD.Inventors: Xiaojun Ni, Chengsheng Fang, Jing Xiong, Jiancheng Wang
-
Publication number: 20220279598Abstract: Embodiments of this application disclose a method for detecting a terminal device in an idle state and a related device. The method includes: sending a first system message, where the first system message includes a first field, and the first field is used to indicate the terminal device in the idle state to periodically initiate random access; and receiving a random access request sent by the terminal device in the idle state, so that the terminal device in the idle state enters a connected state. The network device sends, to the terminal device, the first system message that carries the first field, and the terminal device in the idle state may periodically initiate random access to the network device, to connect the terminal device and the network device. The network device learns, in this way, whether a terminal device exists in a current coverage area.Type: ApplicationFiled: May 19, 2022Publication date: September 1, 2022Inventor: Jing XIONG
-
Publication number: 20220119415Abstract: The present invention relates to novel solid forms of compound (I), [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid forms thereof disclosed herein, which may be used as a TLR7 agonist, or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.Type: ApplicationFiled: December 23, 2021Publication date: April 21, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Katja GROSSE-SENDER, Urs SCHWITTER, Frank STOWASSER, Xuemei WANG, Jing XIONG
-
Publication number: 20220119414Abstract: The present invention relates to novel solid forms of compound (I), [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid forms thereof disclosed herein, which may be used as a TLR7 agonist, or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.Type: ApplicationFiled: December 23, 2021Publication date: April 21, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Katja GROSSE-SENDER, Urs SCHWITTER, Frank STOWASSER, Xuemei WANG, Jing XIONG
-
Patent number: 11230559Abstract: The present invention relates to novel solid forms of compound (I) [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid forms thereof disclosed herein, which may be used as a TLR7 agonist, or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.Type: GrantFiled: January 4, 2018Date of Patent: January 25, 2022Assignee: Hoffmann-La Roche Inc.Inventors: Katja Grosse-Sender, Urs Schwitter, Frank Stowasser, Xuemei Wang, Jing Xiong
-
Patent number: 11142534Abstract: The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.Type: GrantFiled: January 4, 2018Date of Patent: October 12, 2021Assignee: Hoffmann-La Roche Inc.Inventors: Junli Chen, Manuel Konrath, Roland Meier, Yan Ren, Xuemei Wang, Jing Xiong, Jianhua Yu
-
Patent number: 11142132Abstract: A vehicle rack includes a cargo shelf, the cargo shelf including two beams and two fixing rods; four supporting frames, each beam being provided with two supporting frames that are movable along the beam, the two fixing rods being secured between two corresponding supporting frames on the two beams, a U-shaped plug interface being formed at the top of each supporting frame; a mobile frame that is movable along the beams and is U-shaped, the mobile frame including a horizontal rod and two vertical rods, a U-shaped plug interface I being formed at the top of each vertical rod; six connectors, each connector being provided with a clamping interface that opens through at bottom of the connector so that the connector can clamp the beam from top and then be inserted into the U-shaped plug interface or the U-shaped plug interface I; and six bolts.Type: GrantFiled: February 3, 2020Date of Patent: October 12, 2021Assignee: FORCOME (ZHEJIANG) CO., LTD.Inventors: Xiaojun Ni, Chengsheng Fang, Jing Xiong, Jiancheng Wang
-
Publication number: 20210277049Abstract: The present invention relates to a cocrystal of progesterone, which is formed by the active ingredient progesterone and a cocrystal former which is selected from isophthalic acid, 4-formylbenzeneboronic acid and 3-nitrophthalic acid. The present invention also relates to the method for preparing the cocrystal of progesterone and use thereof for increasing the thickness of endometrium, improving progesterone's solubility or increasing progesterone's permeation rate.Type: ApplicationFiled: March 4, 2021Publication date: September 9, 2021Inventors: Lan He, Jing Xiong, Xiangxiang Wu, Xin Zhu, Zhonglin Lu, Yan Shi, Na Zhang, Yang Liu
-
Patent number: 10940803Abstract: A simple vehicle rack includes: a fixing rod, a middle part of the fixing rod being an H-shaped reinforcing seat, the H-shaped reinforcing seat forming an upper sliding slot on a top surface of the fixing rod and forming a lower sliding slot on a bottom surface of the fixing rod; two fixing frames, the fixing frames being fixed on the top surface of the fixing rod and connected to the fixing rod, moving back and forth along the upper sliding slot; and two support frames, the support frames being fixed on the bottom surface of the fixing rod and connected to the fixing rod, moving back and forth along the lower sliding slot.Type: GrantFiled: February 3, 2020Date of Patent: March 9, 2021Assignee: FORCOME (ZHEJIANG) CO., LTD.Inventors: Xiaojun Ni, Chengsheng Fang, Jing Xiong, Jiancheng Wang
-
Publication number: 20200406826Abstract: A simple vehicle rack includes: a fixing rod, a middle part of the fixing rod being an H-shaped reinforcing seat, the H-shaped reinforcing seat forming an upper sliding slot on a top surface of the fixing rod and forming a lower sliding slot on a bottom surface of the fixing rod; two fixing frames, the fixing frames being fixed on the top surface of the fixing rod and connected to the fixing rod, moving back and forth along the upper sliding slot; and two support frames, the support frames being fixed on the bottom surface of the fixing rod and connected to the fixing rod, moving back and forth along the lower sliding slot.Type: ApplicationFiled: February 3, 2020Publication date: December 31, 2020Inventors: Xiaojun NI, Chengsheng FANG, Jing XIONG, Jiancheng WANG
-
Publication number: 20200406827Abstract: A vehicle rack includes two cross beams, the cross beams being hollow square rods parallelly placed, the bottom center of the cross beam being provided with a sliding slot along the beams; two fixing rods, the fixing rods being hollow and each including an H-shaped reinforcing seat, the H-shaped reinforcing seat forming an upper sliding slot I on a top surface of the fixing rod and forming a lower sliding slot I on a bottom surface of the fixing rod, the fixing rods being particular to the two cross beams; a plurality of connecting seat, the connecting seats movably connecting the cross beams and the fixing rods, the connecting seats including upper bolt connecting parts; a plurality of supporting frames, the fixing rods each connecting two supporting frames, the supporting frames including lower bolt connecting parts.Type: ApplicationFiled: February 3, 2020Publication date: December 31, 2020Inventors: Xiaojun NI, Chengsheng FANG, Jing XIONG, Jiancheng WANG
-
Publication number: 20200398764Abstract: A vehicle rack includes a cargo shelf, the cargo shelf including two beams and two fixing rods; four supporting frames, each beam being provided with two supporting frames that are movable along the beam, the two fixing rods being secured between two corresponding supporting frames on the two beams, a U-shaped plug interface being formed at the top of each supporting frame; a mobile frame that is movable along the beams and is U-shaped, the mobile frame including a horizontal rod and two vertical rods, a U-shaped plug interface I being formed at the top of each vertical rod; six connectors, each connector being provided with a clamping interface that opens through at bottom of the connector so that the connector can clamp the beam from top and then be inserted into the U-shaped plug interface or the U-shaped plug interface I; and six bolts.Type: ApplicationFiled: February 3, 2020Publication date: December 24, 2020Inventors: Xiaojun NI, Chengsheng FANG, Jing XIONG, Jiancheng WANG
-
Publication number: 20200308178Abstract: The present invention relates to novel solid forms of compound (I), 3-[(8aS)-7-[[(4S)-5-ethoxycarbonyl-4-(3-fluoro-2-methyl-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid and pharmaceutical compositions comprising solid forms thereof disclosed herein, which can be used as a HBV capsid inhibitor (or HBV Core Protein Allosteric Modifier), or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.Type: ApplicationFiled: March 24, 2020Publication date: October 1, 2020Applicant: Hoffmann-La Roche Inc.Inventors: Jing Xiong, Xuemei Wang
-
Publication number: 20200024287Abstract: The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.Type: ApplicationFiled: January 4, 2018Publication date: January 23, 2020Applicant: Hoffmann-La Roche Inc.Inventors: Junli CHEN, Manuel KONRATH, Roland MEIER, Yan REN, Xuemei WANG, Jing XIONG, Jianhua YU