Abstract: A high-throughput optical sectioning three-dimensional imaging system which includes: a light beam modulation module configured to modulate a light beam into a modulated light beam capable of being focused on a focal plane of an objective lens and being defocused on a defocusing plane of the objective lens; an imaging module configured to employ a camera to image, in different rows of pixels, a sample under illumination of the modulated light beam; a cutting module configured to cut off an imaged surface layer of the sample; a demodulation module configured to demodulate a sample image of one sample strip of one surface layer into an optical sectioning image, and reconstruct the optical sectioning image of each sample strip of each surface layer into a three-dimensional image. The present disclosure achieves imaging of a whole sample by dividing the sample into at least one surface layer, dividing the at least one surface layer into at least one sample strip, and imaging each sample strip.

Abstract: An internal combustion engine featuring a radial array of cylinders and pistons; the pistons having rods including cam followers engaging the surface of a cam drive to transfer reciprocating linear motion into rotary motion; wherein between the piston rods and the engine housing are disposed arrays of toothed rollers to provide a rolling interface.

Abstract: A high-throughput optical sectioning imaging method and imaging system. The method includes: modulating a light beam into a modulated light beam capable of being focused on a focal plane of an objective lens and being defocused on a defocusing plane of the objective lens, the modulated light beam having incompletely identical modulated intensities on the focal plane of the objective lens; imaging, in different rows of pixels, a sample under illumination of the modulated light beam to obtain sample images in the different rows of pixels; obtaining focal plane images of sample images in the different rows of pixels by demodulation of the sample images according to a demodulation algorithm. The system includes a light beam modulation module, an imaging module and a demodulation module.

Abstract: A tunable optical device including a substrate, at least one support unit, a flexible frame, an elastic component, a first reflector, and at least one actuator is provided. The support unit is fixed onto the substrate. The flexible frame is connected to the support unit and suspended above the substrate. The elastic component is connected to the flexible frame. A stiffness of the elastic component in the Z-axis is smaller than a stiffness of the flexible frame in the Z-axis. The Z-axis direction is parallel to a normal direction of the substrate. The first reflector is connected to the elastic component. The actuator is located between the flexible frame and the substrate or located between the first reflector and the substrate.

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification.

Abstract: Disclosed is a use of a liposomal pharmaceutical preparation of mitoxantrone in the preparation of a medicament for treating lymphoma, wherein the lymphoma is preferably non-Hodgkin's lymphoma, further preferably aggressive non-Hodgkin's lymphoma, more preferably diffuse large B-cell lymphoma or peripheral T-cell lymphoma, and more further preferably relapsed or refractory diffuse large B-cell lymphoma or peripheral T-cell lymphoma. The mitoxantrone liposomes are used as single anti-tumor therapeutic agent without being combined with other anti-tumor agents.

Abstract: A multi-level buck converter includes an input power source, an input capacitor, first to fourth switches, a clamp capacitor, an output inductor, a clamp switch, a clamp diode, an output capacitor, an output load, a current detection circuit, a voltage detection circuit and a control circuit. The current detection circuit detects whether an inductor current of the output inductor exceeds a predetermined current value, and if so, the output clamp signal controls the clamp switch to be turned on. The voltage detection circuit generates a duty cycle control signal according to an error between an output voltage and a target output voltage. The control circuit controls the first to the fourth switches to sequentially enter a first mode, a second mode, a third mode, and a fourth mode in a first part of a duty cycle.

Abstract: Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

Abstract: A MEMS device is provided. The MEMS device includes a substrate having at least one contact, a first dielectric layer disposed on the substrate, at least one metal layer disposed on the first dielectric layer, a second dielectric layer disposed on the first dielectric layer and the metal layer and having a recess structure, and a structure layer disposed on the second dielectric layer and having an opening. The opening is disposed to correspond to the recess structure, and the cross-sectional area at the bottom of the opening is smaller than the cross-sectional area at the top of the recess structure. The MEMS device also includes a packaging layer, and at least a portion of the packaging layer is disposed in the opening and the recess structure. The second dielectric layer, the structure layer, and the packaging layer define a chamber.

Abstract: A full bridge converter having a wide output voltage range includes an input power source, a full bridge switching circuit, a transformer, a first rectifying circuit, a second rectifying circuit, a first output circuit, a second output circuit, and a control circuit. The transformer includes a magnetic core, a primary side winding, a first secondary side winding, and a second secondary side winding. The first rectifying circuit includes a first AC switch, a second AC switch and a first freewheeling diode, and the second rectifying circuit includes a third AC switch, a fourth AC switch and a second freewheeling diode. The control circuit, according to a duty cycle, controls the first AC switch and the third AC switch to be turned on during a positive half cycle, and controls the second AC switch and the fourth AC switch to be turned on during a negative half cycle.

Abstract: A totem-pole bridgeless power factor corrector and a power factor correction method are provided. The totem-pole bridgeless power factor corrector obtains a duty cycle of next state by a predictive valley-peak current control method, and uses an OR gate element to combine PWM signals generated by an average current control method and the predictive valley-peak current control method, thereby enabling a digital signal processor to update the duty cycle.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: Provided is an underwater repair system for a cavity region of a concrete panel rock-fill dam panel, including a moving platform, a work cabin, a pressure drainage apparatus, a traction apparatus, and a positioning apparatus; the traction apparatus controlling the movement of the moving platform on the surface of a dam concrete panel; the positioning apparatus transmits a detection position, the work cabin is a pressure cabin, the work cabin being connected to the pressure drainage apparatus, and a drill apparatus and grouting apparatus being arranged in the work cabin; the moving platform moves into the cavity region, and the pressure drainage apparatus starts up to drain the water in the work cabin, a partially closed waterless space being formed inside the work cabin, the drill apparatus drilling the concrete panel at the upper end of the cavity region and the grouting apparatus subsequently implementing grouting to complete the repair.

Abstract: A multi-level buck converter includes an input power source, an input capacitor, first to fourth switches, a clamp capacitor, an output inductor, a clamp switch, a clamp diode, an output capacitor, an output load, a current detection circuit, a voltage detection circuit and a control circuit. The current detection circuit detects whether an inductor current of the output inductor exceeds a predetermined current value, and if so, the output clamp signal controls the clamp switch to be turned on. The voltage detection circuit generates a duty cycle control signal according to an error between an output voltage and a target output voltage. The control circuit controls the first to the fourth switches to sequentially enter a first mode, a second mode, a third mode, and a fourth mode in a first part of a duty cycle.

Abstract: A full bridge converter having a wide output voltage range includes an input power source, a full bridge switching circuit, a transformer, a first rectifying circuit, a second rectifying circuit, a first output circuit, a second output circuit, and a control circuit. The transformer includes a magnetic core, a primary side winding, a first secondary side winding, and a second secondary side winding. The first rectifying circuit includes a first AC switch, a second AC switch and a first freewheeling diode, and the second rectifying circuit includes a third AC switch, a fourth AC switch and a second freewheeling diode. The control circuit, according to a duty cycle, controls the first AC switch and the third AC switch to be turned on during a positive half cycle, and controls the second AC switch and the fourth AC switch to be turned on during a negative half cycle.

Abstract: Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

Abstract: Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

Abstract: A totem-pole bridgeless power factor corrector and a power factor correction method are provided. The totem-pole bridgeless power factor corrector obtains a duty cycle of next state by a predictive valley-peak current control method, and uses an OR gate element to combine PWM signals generated by an average current control method and the predictive valley-peak current control method, thereby enabling a digital signal processor to update the duty cycle.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A combination for improving intestinal micro-ecology and preventing chronic diseases includes an inulin, a galactooligosaccharide and a dietary fiber composite, wherein the ratio of the inulin, the galactooligosaccharide and the dietary fiber composite in a formula is (1-75):(1-75):(5-95). Preferably, the ratio is (10-50):(10-50):(25-50). A balanced nutritious food includes cereal flour and the ratio of the cereal flour to the combination in a formula is (50-95):(5-50). Preferably, the ratio is (70-95):(30-5). Moreover, provided is an application in preparing foods or medicaments for preventing inflammatory bowel disease, improving gastrointestinal motility and preventing constipation, preventing diabetes, preventing cardiovascular and cerebrovascular diseases, and regulating intestinal flora to enhance immune ability.