Abstract: The present invention belongs to the medical field, and relates to novel ?-lactamase inhibitors, for the treatment of bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I): or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: Thermally responsive compositions that include a thermally responsive viscosity modifier, a polymerizable component, and water are provided. The compositions, which optionally may be hardened, are useful for application to a surface of a body.

Abstract: Ophthalmic compositions comprising Inhibitors of Janus kinase-3 (“Jak3”) are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

Abstract: Inhibitors of Janus kinase-3 (“Jak3”) are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. Jak3 inhibitors useful for treating eye disorders include the compound 3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile.

Abstract: Thermally responsive compositions that include a thermally responsive viscosity modifier, a polymerizable component, and water are provided. The compositions, which optionally may be hardened, are useful for application to a surface of a body.

Abstract: Thermally responsive compositions that include a thermally responsive viscosity modifier, a polymerizable component, and water are provided. The compositions, which optionally may be hardened, are useful for application to a surface of a body.

Abstract: Provided is a treated substrate comprising a backing material coated with a resin derived from a curable precursor resin, which comprises an energy-curable component comprising a cyanate ester resin and a curing agent. Also provided is an abrasive article comprising a plurality of abrasive particles incorporated into a bond system, wherein the bond system comprises a make resin derived from a first curable precursor resin, which comprises a first curable component comprising a cyanate ester resin and a first curing agent, and wherein the bond system additionally comprises a size resin derived from a second curable precursor resin, which comprises a second curable component comprising a cyanate ester resin and a second curing agent. Also provided are methods of making a treated substrate and an abrasive article.

Abstract: Provided is a treated substrate comprising a backing material coated with a resin derived from a curable precursor resin, which comprises an energy-curable component comprising a cyanate ester resin and a curing agent. Also provided is an abrasive article comprising a plurality of abrasive particles incorporated into a bond system, wherein the bond system comprises a make resin derived from a first curable precursor resin, which comprises a first curable component comprising a cyanate ester resin and a first curing agent, and wherein the bond system additionally comprises a size resin derived from a second curable precursor resin, which comprises a second curable component comprising a cyanate ester resin and a second curing agent. Also provided are methods of making a treated substrate and an abrasive article.