Patents by Inventor Jingye Zhou

Jingye Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thyroid hormone receptor agonists and use thereof
    Patent number: 11780825
    Abstract: The application relates to a compound of Formula (I?) or (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I?) or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: October 10, 2023
    Assignee: Eccogene (Shanghai) Co., Ltd.
    Inventors: Jingye Zhou, Jiuxiang Zhu, Mingwei Zheng
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20230122651
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: April 12, 2022
    Publication date: April 20, 2023
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plarnondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • Substituted imidazoles as GLP-1 receptor agonists
    Patent number: 11584751
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: February 21, 2023
    Assignee: Eccogene (Shanghai) Co., Ltd.
    Inventors: Zaifang Ren, Xuefeng Sun, Jingye Zhou, Qing Xu
  • TETRAHYDROPYRAZOLO-PYRAZINYL-DIHYDROIMIDAZOLONE OR TETRAHYDROPYRAZOLO-PYRIDINYL-DIHYDROIMIDAZOLONE COMPOUNDS AND METHODS OF USING SAME
    Publication number: 20230051320
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.
    Type: Application
    Filed: July 20, 2021
    Publication date: February 16, 2023
    Inventors: Zaifang REN, Xuefeng SUN, Jingye ZHOU, Qing XU
  • PHENYL-[1,3]DIOXOLO[4,5-C]PYRIDINYL-PHENYL-, PHENYL-[1,3]DIOXOLO[4,5-C]PYRIDINYL-HETEROARYL-, OR PHENYL-(1,3)DIOXO[4,5-C]PYRIDINYL-PIPERIDINYL-METHYL-OXETANYLMETHYL-1H-BENZO[D]IMIDAZOLE-CARBOXYLIC ACID DERIVATIVES AND METHODS OF USING SAME
    Publication number: 20220348564
    Abstract: The application relates to a compound of Formula (Y) or Formula (A): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.
    Type: Application
    Filed: March 24, 2022
    Publication date: November 3, 2022
    Inventors: Zaifang REN, Xuefeng SUN, Jingye ZHOU
  • THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF
    Publication number: 20210230146
    Abstract: The application relates to a compound of Formula (I?) or (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I?) or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.
    Type: Application
    Filed: January 13, 2021
    Publication date: July 29, 2021
    Inventors: Jingye ZHOU, Jiuxiang ZHU, Mingwei ZHENG
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20210122709
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: June 10, 2020
    Publication date: April 29, 2021
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • Pyrrolidinone compounds
    Patent number: 10807971
    Abstract: The present invention provides compounds which are of the formula (I) and (II) wherein X is selected from the group consisting of (III) and (IV); R is selected from the group consisting of (V) and (VI); Q is selected from the group consisting of (VII) and (VIII); and (IX) R2 is selected from the group consisting of (X) and (XI); or a pharmaceutically acceptable salt thereof, methods for treating obesity, type II diabetes, and compositions.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: October 20, 2020
    Assignee: Eli Lilly and Company
    Inventors: Koc Kan Ho, Weiguo Quan, Jingye Zhou
  • Amino pyrimidine ssao inhibitors
    Patent number: 10793552
    Abstract: The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: October 6, 2020
    Assignee: ELI LILLY AND COMPANY
    Inventors: David Andrew Coates, Luo Heng Qin, Yi Wei, Jingye Zhou
  • AMINO PYRIMIDINE SSAO INHIBITORS
    Publication number: 20200262817
    Abstract: The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds,
    Type: Application
    Filed: September 26, 2019
    Publication date: August 20, 2020
    Applicant: Eli Lilly and Company
    Inventors: David Andrew COATES, Luo Heng QIN, Yi WEI, Jingye ZHOU
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20200055813
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: April 1, 2019
    Publication date: February 20, 2020
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • PYRROLIDINONE COMPOUNDS
    Publication number: 20190345144
    Abstract: The present invention provides compounds which are of the formula (I) and (II) wherein X is selected from the group consisting of (III) and (IV); R is selected from the group consisting of (V) and (VI); Q is selected from the group consisting of (VII) and (VIII); and (IX) R2 is selected from the group consisting of (X) and (XI); or a pharmaceutically acceptable salt thereof, methods for treating obesity, type II diabetes, and compositions.
    Type: Application
    Filed: November 27, 2017
    Publication date: November 14, 2019
    Inventors: Koc Kan Ho, Weiguo Quan, Jingye Zhou
  • Amino pyrimidine compounds useful as SSAO inhibitors
    Patent number: 10471060
    Abstract: The present invention provides compounds of the formula below pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: November 12, 2019
    Assignee: Eli Lilly and Company
    Inventors: Mengyang Fan, Luoheng Qin, Yi Wei, Guoqiang Zhou, Jingye Zhou
  • Amino pyrimidine SSAO inhibitors
    Patent number: 10464928
    Abstract: The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: November 5, 2019
    Assignee: Eli Lilly and Company
    Inventors: David Andrew Coates, Luo Heng Qin, Yi Wei, Jingye Zhou
  • AMINO PYRIMIDINE SSAO INHIBITORS
    Publication number: 20190276436
    Abstract: The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and RI are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 12, 2019
    Applicant: Eli Lilly and Company
    Inventors: David Andrew COATES, Luo Heng QIN, Yi WEI, Jingye ZHOU
  • AMINO PYRIMIDINE COMPOUNDS USEFUL AS SSAO INHIBITORS
    Publication number: 20190275041
    Abstract: The present invention provides compounds of the formula below pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 12, 2019
    Applicant: Eli Lilly and Company
    Inventors: Mengyang FAN, Luoheng QIN, Yi WEI, Guoqiang ZHOU, Jingye ZHOU
  • Amino pyrimidine SSAO inhibitors
    Patent number: 10287270
    Abstract: The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: May 14, 2019
    Assignee: ELI LILLY AND COMPANY
    Inventors: David Andrew Coates, Luo Heng Qin, Yi Wei, Jingye Zhou
  • Amino pyrimidine compounds useful as SSAO inhibitors
    Patent number: 10278970
    Abstract: The present invention provides compounds of the formula below pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: May 7, 2019
    Assignee: ELI LILLY AND COMPANY
    Inventors: Mengyang Fan, Luoheng Qin, Yi Wei, Guoqiang Zhou, Jingye Zhou
  • Tetrahydropyranyl benzamide derivatives
    Patent number: 10196385
    Abstract: The present invention provides compounds of the Formula below wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: February 5, 2019
    Assignee: Eli Lilly and Company
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Haizhen Zhang, Jingye Zhou
  • AMINO PYRIMIDINE COMPOUNDS USEFUL AS SSAO INHIBITORS
    Publication number: 20180296560
    Abstract: The present invention provides compounds of the formula below pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds.
    Type: Application
    Filed: June 19, 2018
    Publication date: October 18, 2018
    Inventors: Mengyang Fan, Luoheng Qin, Yi Wei, Guoqiang Zhou, Jingye Zhou