Abstract: A system and method for MRI are provided. An initial spatial factor may be based on first MRI signals collected in a first imaging stage of an MRI scan of a subject. Second MRI signals collected during a second imaging stage of the MRI scan after the first imaging stage may be obtained. Temporal factors or/and updated spatial factors may be determined. Each of the temporal factors may be determined based on the second MRI signals collected before the determination of the temporal factor. Each of the updated spatial factors may be determined based on the second MRI signals collected before the determination of the updated spatial factor. Real-time MRI images within the second imaging stage may be generated. Each of the real-time MRI images may be generated based on the latest determined temporal factor and one of the initial spatial factor or the latest determined spatial factor.

Abstract: An imaging method may include obtaining imaging data associated with a region of interest (ROI) of an object. The imaging data may correspond to a plurality of time-series images of the ROI. The imaging method may also include determining, based on the imaging data, a data set including a spatial basis and one or more temporal bases. The spatial basis may include spatial information of the imaging data. The one or more temporal bases may include temporal information of the imaging data. The imaging method may also include storing, in a storage medium, the spatial basis and the one or more temporal bases.

Abstract: A method for magnetic resonance imaging (MRI) may include obtaining imaging signals related to a region of interest (ROI) of a subject. The method may also include selecting a portion of the imaging signals as auxiliary signals associated with at least one temporal dimension of the ROI. The method may also include generating at least one target image associated with the at least one temporal dimension of the ROI based on the imaging signals and the auxiliary signals.

Abstract: A system and method for MRI are provided. An initial spatial factor may be based on first MRI signals collected in a first imaging stage of an MRI scan of a subject. Second MRI signals collected during a second imaging stage of the MRI scan after the first imaging stage may be obtained. Temporal factors or/and updated spatial factors may be determined. Each of the temporal factors may be determined based on the second MRI signals collected before the determination of the temporal factor. Each of the updated spatial factors may be determined based on the second MRI signals collected before the determination of the updated spatial factor. Real-time MRI images within the second imaging stage may be generated. Each of the real-time MRI images may be generated based on the latest determined temporal factor and one of the initial spatial factor or the latest determined spatial factor.

Abstract: The present disclosure provides an in vitro cell based potency assay to determine the relative potency of a composition, including a pharmaceutical composition, comprising an mRNA encapsulated in a lipid nanoparticle (LNP) as compared to a reference sample. Also provided is a process for releasing or accepting a batch of a pharmaceutical composition comprising an mRNA encapsulated in an LNP using the in vitro cell based potency assay. The methods and processes described comprise (i) transfecting a population of cells with a test sample of the composition, (ii) transfecting a different population of cells with a reference sample of the pharmaceutical composition, wherein the cells in step (ii) are the same cell type as the cells in step (i); (iii) detecting the amount of expression of a polypeptide encoded by the mRNA in the transfected cells; and comparing the amount of expression, thereby determining the relative in vitro potency of the composition.

Abstract: This disclosure provides a method for evaluating volume responsiveness and a medical device. The medical device includes a respiratory assistance device for providing respiratory support for a patient, and a first sensor for collecting physiological parameters of the patient and a processor. When volume responsiveness evaluation is needed, the processor controls ventilation parameters to switch to a second ventilation parameter that may increase the variation of the intrathoracic pressure of the patient, and then uses a parameter variation capable of reflecting the heartbeat of the patient to evaluate whether the patient is volume responsive.

Abstract: The present invention relates to superabsorbent biobased hydrogels prepared with sodium carboxymethyl cellulose (CMCNa) and hydroxyethyl cellulose (HEC) cross-linked with either citric acid, succinic acid, or sebacic acid. The swelling ratio of the superabsorbent hydrogels of the invention was dependent on the cross-linker used, the concentration of the cross-linker, and the cross-linking temperature.

Abstract: Disclosed is a bio-based and environmentally friendly elastomer product from renewable agricultural substrates. Specifically, glutamine and arginine residues of gliadin are used as synthons to produce novel elastomeric product from the reaction of the oxirane groups of epoxidized vegetable oils under neat reaction conditions with the primary amide functionalities of glutamine and arginine to give the corresponding amidohyroxy gliadinyl triglycerides.