Abstract: An electrode cell manufacturing process may include forming an electrode sheet including an electrode material and an active material. A first plurality of electrode tab windows may be defined in the active material to expose first portions of the electrode material. The process may also include slitting the electrode sheet along a first line that orthogonally intersects the first plurality of electrode tab windows to define a first electrode strip including a first set of electrodes and a second electrode strip including a second set of electrodes.

Abstract: Described herein are novel compositions comprising lipid-poly(ethylene glycol) (lipid-PEG) molecules or lipid-PEG like molecules, and methods of use thereof, e.g., for sustained delivery of therapeutic agents such as nucleic acids, proteins, and small molecules.

Abstract: Battery packs having jelly roll battery cells of different capacities may have an imbalance in the charging and/or discharging current supplied to and provided by each jelly roll due to differences in capacity specific impedance between the battery cells of the battery pack. A C-rate (i.e., current relative to rated capacity) of a lower capacity first battery cell and a higher capacity second battery cell connected in parallel may be balanced by repositioning and/or increasing the number of cathode tabs and anode tabs of the second jelly roll battery cell to reduce an impedance of the second battery cell.

Abstract: The disclosed technology relates to balanced battery packs having battery cells of different capacities with higher capacity battery cells having a reduced impedance compared to lower capacity battery cells in the battery pack. The battery pack includes at least a first and second battery cell connected in parallel, with the second battery cell having a higher capacity than a capacity of the first battery cell. Tabs extending from electrodes of the second battery cell are disposed near a center of the electrodes to reduce an impedance of the second battery cell.

Abstract: Disclosed herein is a composite particulate comprising a plurality of active material particles; and a single graphene sheet or a plurality of graphene sheets surrounds the plurality of active material particles and a surface of the composite particulate, wherein a single graphene sheet or a plurality of graphene sheets provides an electron-conducting path.

Abstract: The disclosed technology relates to a looped tab for a battery cell. The looped tab may extend from a set of layers. The looped tab may comprise a first portion adjacent to the set of layers, and a second portion adjacent to an inner sidewall of the enclosure. At least a portion of the first portion and at least a portion of the second portion comprise a covered portion. The covered portion comprises a metal surface and an oxide coating covering the metal surface. The oxide coating is configured to prevent contact between a layer in the set of layers or the inner sidewall of the enclosure and the metal surface.

Abstract: The disclosed technology relates to a looped tab for a battery cell. The looped tab may extend from a set of layers. The looped tab may comprise a first portion adjacent to the set of layers and a second portion adjacent to an inner sidewall of the enclosure. The first portion may comprise a covered portion, the covered portion comprising a metal surface and an oxide coating covering the metal surface, the oxide coating configured to prevent contact between a layer in the set of layers or the enclosure and the metal surface of the covered portion.

Abstract: Battery packs having jelly roll battery cells of different designs or capacities may have an imbalance in the charging and/or discharging current supplied to and provided by each jelly roll due to differences in capacity specific impedance between the battery cells of the battery pack. A C-rate (i.e., current relative to rated capacity) of a first and second battery cell connected in parallel may be balanced by altering properties of an active layer and/or a thickness of a current collector of the second battery cell to reduce an impedance of the second battery cell.

Abstract: A battery system includes a battery cell, a thermoelectric cooler (TEC) that cools the battery cell, a temperature sensor that detects a temperature of the battery cell, and a battery management unit (BMU) controller. The BMU controller activates the TEC to cool the battery cell in response to determining that a state of charge (SOC) of the battery cell is greater than a threshold SOC and the temperature of the battery cell is greater than a threshold temperature.

Abstract: Battery packs having jelly roll battery cells of different designs or capacities may have an imbalance in the charging and/or discharging current supplied to and provided by each jelly roll due to differences in capacity specific impedance between the battery cells of the battery pack. A C-rate (i.e., current relative to rated capacity) of a first and second battery cell connected in parallel may be balanced by altering properties of an active layer and/or a thickness of a current collector of the second battery cell to reduce an impedance of the second battery cell.

Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.

Abstract: Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.

Abstract: Battery packs according to embodiments of the present technology may include a first battery cell including a lithium-containing material. The first battery cell may be configured to operate in a voltage window extending to or above about 4 V. The battery packs may include a second battery cell electrically coupled in parallel with the first battery cell. The second battery cell may be configured to operate in a voltage window maintained at or below about 4.0 V. The battery packs may also include a controller configured to receive a measured terminal voltage from the first battery cell. The controller may be configured to determine whether to disconnect the second battery cell from the first battery cell based on the measured terminal voltage of the first battery cell.

Abstract: The present application provides a method of treating a cancer, including administering to a subject in need of cancer treatment a therapeutically effective amount of an mRNA encoding tumor suppressor protein p53 in combination with an anticancer therapeutic agent, or a pharmaceutically acceptable salt thereof, wherein the anticancer therapeutic agent is selected from an mTOR inhibitor, a platinum-based antineoplastic agent, and an AMPK activating agent.

Abstract: Nanoparticulate pharmaceutical formulations and methods for co-delivery of two or more species of nucleic acids for simultaneous suppression and expression of target genes in a cell, are provided. The nanoparticles encapsulate two or more nucleic acid species. The first nucleic acid suppresses expression of a gene or product thereof, e.g., inhibitory nucleic acid, such as antisense, siRNA, miRNA, Dicer siRNA, piRNA, etc. The second nucleic acid increases expression of, or encodes, an endogenous or exogenous protein or polypeptide, e.g., an mRNA. The first and second nucleic acid species simultaneously target or affect the same or different cellular processes within a cell including communication, senescence, DNA repair, gene expression, metabolism, necrosis, and apoptosis.

Abstract: This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia): and a repeating unit of Formula (Ib): wherein W1, W2, X1, A1, X2, A2, and X3 are as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.

Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.

Abstract: Battery packs according to embodiments of the present technology may include a first battery cell including a lithium-containing material. The first battery cell may be configured to operate in a voltage window extending to or above about 4 V. The battery packs may include a second battery cell electrically coupled in parallel with the first battery cell. The second battery cell may be configured to operate in a voltage window maintained at or below about 4.0 V. The battery packs may also include a controller configured to receive a measured terminal voltage from the first battery cell. The controller may be configured to determine whether to disconnect the second battery cell from the first battery cell based on the measured terminal voltage of the first battery cell.

Abstract: Batteries according to embodiments of the present technology may include an enclosure. The batteries may include an electrode stack including a separator positioned between an anode and a cathode. The electrode stack may be characterized by a first side from which a plurality of electrode tabs extend, a second side opposite the first, a third side, and a fourth side opposite the third. The batteries may also include a wrapping seated on a first surface of the electrode stack and extending beyond an edge of each of the second, the third, and the fourth sides of the electrode stack a distance equal to or greater than a thickness of the electrode stack. The wrapping may be adhered to a second surface of the electrode stack opposite the first surface of the electrode stack on each of the second side, the third side, and the fourth side of the electrode stack.

Abstract: The disclosed technology relates to battery packs having battery cells of different designs or capacities with an imbalance in the charging and/or discharging current supplied to and provided by each jelly roll due to differences in capacity specific impedance between the battery cells of a battery pack. The battery pack includes at least a first and second battery cell connected in parallel, with a thickness of an active layer and/or current collector of a battery cell having an altered thickness to reduce an impedance of the battery cell.