Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof.

Abstract: The present application relates to a wiper arm, which comprises a wiper arm body and a wiper arm end piece, the wiper arm end piece being fixedly connected to one end of the wiper arm body to hold a wiper blade, the wiper arm being further provided with a nozzle and a hose, wherein the nozzle is connected to an extension section of the wiper arm end piece towards the return side or the outward swing side of the wiper arm; the hose extends along the wiper arm body, and one end of the hose is connected to the nozzle to deliver a cleaning fluid to the nozzle. The arrangement of a nozzle on the wiper arm ensures that a cleaning fluid is quickly wiped off, the driver is given a clear field of vision, and the cleaning fluid usage may also be reduced.

Abstract: A method is disclosed for making a liquid crystal composite in which droplets of a liquid crystal material are dispersed in a polymer matrix. At least one further material separates the liquid crystal material from the polymer matrix. This construction permits the polymer matrix to be selected on the basis of its environmental properties and the further material to be selected on the basis of its orientational interactions with liquid crystal material. Light valves made from such a composite exhibit improved electro-optical properties.

Abstract: A method is disclosed for making a liquid crystal composite in which droplets of a liquid crystal material are dispersed in a polymer matrix. At least one further material separates the liquid crystal material from the polymer matrix. This construction permits the polymer matrix to be selected on the basis of its environmental properties and the further material to be selected on the basis of its orientational interactions with liquid crystal material. Light valves made from such a composite exhibit improved electro-optical properties.