Abstract: Disclosed herein is a method which includes extracting genomic deoxyribonucleic acid (DNA) at locations at or near cancer hotspots from a subject, modifying Tier-1 5hmC on the DNA to a modified 5hmC, detecting and identifying the presence or absence of the modified 5hmC, quantifying the detected and identified modified 5hmC; and providing a report comprising a score, wherein the score is indicative of the presence of cancer.

Abstract: Disclosed herein is a method which includes extracting genomic deoxyribonucleic acid (DNA) at locations at or near cancer hotspots from a subject, modifying Tier-1 5hmC on the DNA to a modified 5hmC, detecting and identifying the presence or absence of the modified 5hmC, quantifying the detected and identified modified 5hmC; and providing a report comprising a score, wherein the score is indicative of the presence of cancer.

Abstract: A cover and chute handling apparatus for use in combination with a bottom head of a coker is described. The apparatus includes rails positioned adjacent to the bottom head of the coker. A bottom head cover and a spacer are suspended by the rails and slide thereon. A force ring is suspended beneath the bottom head cover or the spacer. Force ring actuators are connected to the force ring and move the force ring to press either the bottom head cover or the spacer against the bottom head of the coker. A chute may be connected to the force ring so that the chute is positioned adjacent to the bottom head of the coker during emptying of the coker. The chute directs effluents from the coker to a receiving area. A method of emptying a coker is also described.

Abstract: A system is disclosed for automatically removing the cover of a chute beneath a coke drum. The system operates in conjunction with a remotely operable coke deheading device so that the chute cover is removed when the coke drum is deheaded. Also disclosed is a method for facilitating coke removal from a coke drum into a coke chute where the chute cover is automatically removed upon activation of the coke drum deheading device.