Patents by Inventor Jiri Voller
Jiri Voller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230055908Abstract: A para-topolin mesylate salt and its crystalline form is disclosed. Cosmetic and therapeutic applications, and compositions containing this compound, are also disclosed. Mesylate salt of para-topolin has a wide range of biological activities, including antioxidative, anti-inflammatory, anti-senescent and anti-aging while showing low toxicity and excellent solubility.Type: ApplicationFiled: August 22, 2020Publication date: February 23, 2023Applicant: USTAV EXPERIMENTALNI BOTANIKY AV CR, V. V. I.Inventors: Lucie PLIHALOVA, Marek ZATLOUKAL, Karel DOLEZAL, Miroslav STRNAD, Jan WALLA, Jiri VOLLER
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Publication number: 20230039704Abstract: N-(furan-2-ylmethyl)-7H-purin-6-amine, or a pharmaceutically acceptable salt or solvate thereof, for prevention and/or treatment of circadian rhythm disorders, circadian rhythm diseases and/or circadian rhythm dysfunctions is disclosed. The disorders, diseases and dysfunctions include, inter alia, jet-lag, social jet-lag, shift-work disorder, and circadian rhythm disturbance induced by neurodegeneration is also disclosed.Type: ApplicationFiled: December 8, 2020Publication date: February 9, 2023Applicants: UNIVERZITA PALACKEHO V OLOMOUCI, FYZIOLOGICKY USTAV AV CR, V. V. I.Inventors: Jiri VOLLER, Martin SLADEK, Marian HAJDUCH, Alena SUMOVA, Miroslav STRNAD
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Patent number: 10774084Abstract: Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA/UVB effects. These substances are particularly suitable as anti-senescent and UV-photoprotective component in cosmetic preparations, plant protection preparations and in preparations for the treatment/application of tissue cultures.Type: GrantFiled: August 24, 2016Date of Patent: September 15, 2020Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Martin Hönig, Lucie Plihalova, Karel Dolezal, Jiri Voller, Miroslav Strnad, Lukas Spichal, Jitka Vostalova, Alena Rajnochova Svobodova, Jitka Ulrichova, Alena Kadlecova, Ondrej Plihal
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Patent number: 10550144Abstract: 6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents ?-D-arabinofuranosyl or ?-D-2?-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use for regulation, in particular inhibition, of aging in plants in vivo or plant cells in vitro, and for regulation of growth and development of plants in vivo, plant tissues, plant organs and plant cells in vitro.Type: GrantFiled: December 2, 2015Date of Patent: February 4, 2020Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Karel Dolezal, Lucie Plihalova, Hana Vylicilova, Marek Zatloukal, Ondrej Plihal, Jiri Voller, Miroslav Strnad, Johannes Van Staden, Ponnusamy Baskaran, Aloka Kumari, Adeyemi Oladapo Aremu
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Publication number: 20180298004Abstract: Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA/UVB effects.Type: ApplicationFiled: August 24, 2016Publication date: October 18, 2018Applicant: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Martin HÖNIG, Lucie PLIHALOVA, Karel DOLEZAL, Jiri VOLLER, Miroslav STRNAD, Lukas SPICHAL, Jitka VOSTALOVA, Alena RAJNOCHOVA SVOBODOVA, Jitka ULRICHOVA, Alena KADLECOVA, Ondrej PLIHAL
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Patent number: 10100077Abstract: 6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents ?-D-arabinofuranosyl or ?-D-2?-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use as antisenescent and UV protective compounds in animals.Type: GrantFiled: September 14, 2015Date of Patent: October 16, 2018Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Karel Dolezal, Lucie Plihalova, Hana Vylicilova, Marek Zatloukal, Ondrej Plihal, Jiri Voller, Miroslav Strnad, Magdalena Bryksova, Jitka Vostalova, Alena Rajnochova Svobodova, Jitka Ulrichova, Lukas Spichal
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Patent number: 10093675Abstract: 6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These 6,8-disubstituted-9-(heterocyclyl)purines have a wide range of biological activities, including for example antioxidant, anti-inflammatory, anti-senescent, anti-aging, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. Compositions may include additional excipients and auxiliary substances. Methods of treatment of animals, mammals, plants, cells, yeast, and cells in tissue culture are also disclosed.Type: GrantFiled: October 21, 2015Date of Patent: October 9, 2018Assignees: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lenka Zahajska, Jaroslav Nisler, Alena Kadlecova, Marek Zatloukal, Jiri Gruz, Jiri Voller, Karel Dolezal, Miroslav Strnad
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Publication number: 20170362236Abstract: 6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These 6,8-disubstituted-9-(heterocyclyl)purines have a wide range of biological activities, including for example antioxidant, anti-inflammatory, anti-senescent, anti-aging, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. Compositions may include additional excipients and auxiliary substances. Methods of treatment of animals, mammals, plants, cells, yeast, and cells in tissue culture are also disclosed.Type: ApplicationFiled: October 21, 2015Publication date: December 21, 2017Applicants: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lenka ZAHAJSKA, Jaroslav NISLER, Alena KADLECOVA, Marek ZATLOUKAL, Jiri GRUZ, Jiri VOLLER, Karel DOLEZAL, Miroslav STRNAD
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Publication number: 20170334943Abstract: 6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents ?-D-arabinofuranosyl or ?-D-2?-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use as antisenescent and UV protective compounds in animals.Type: ApplicationFiled: September 14, 2015Publication date: November 23, 2017Applicant: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Karel DOLEZAL, Lucie PLIHALOVA, Hana VYLICILOVA, Marek ZATLOUKAL, Ondrej PLIHAL, Jiri VOLLER, Miroslav STRNAD, Magdalena BRYKSOVA, Jitka VOSTALOVA, Alena RAJNOCHOVA SVOBODOVA, Jitka ULRICHOVA, Lukas SPICHAL
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Publication number: 20170326168Abstract: 6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents ?-D-arabinofuranosyl or ?-D-2?-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use for regulation, in particular inhibition, of aging in plants in vivo or plant cells in vitro, and for regulation of growth and development of plants in vivo, plant tissues, plant organs and plant cells in vitro.Type: ApplicationFiled: December 2, 2015Publication date: November 16, 2017Applicant: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Karel DOLEZAL, Lucie PLIHALOVA, Hana VYLICILOVA, Marek ZATLOUKAL, Ondrej PLIHAL, Jiri VOLLER, Miroslav STRNAD, Johannes VAN STADEN, Ponnusamy BASKARAN, Aloka KUMARI, Adeyemi Oladapo AREMU
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Patent number: 9073961Abstract: The invention relates to substitution derivatives of N6-benzyladenosine-5?-monophosphate of the general formula I, wherein (R)n represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising C1 to C8 alkyl, C1 to C8 alkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. This invention also relates to methods of their preparation, their use as medicaments and in other biotechnological applications, and a therapeutic composition containing these derivatives.Type: GrantFiled: April 28, 2011Date of Patent: July 7, 2015Assignees: UNIVERZITA PALACKEHO V OLOMOUCI, BIOAPEX, S.R.O.Inventors: Marek Zatloukal, Karel Dolezal, Jiri Voller, Lukas Spichal, Miroslav Strnad
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Patent number: 8575182Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.Type: GrantFiled: May 26, 2011Date of Patent: November 5, 2013Assignee: Institute of Experimental Botany, Academy of Sciences of the Czeck RepublicInventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
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Publication number: 20130072506Abstract: 6,8-Disubstituted purines which can be used in drug and cosmetic compositions and/or applications are provided. These 6,8-disubstituted purines have a wide range of biological activities, including for example anti-inflammatory, anti-senescent, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. The 6,8-disubstituted purine compounds and compositions containing such 6,8-disubstituted purines provide growth-regulatory, differentiating, antisenescent and antiaging properties with improved selectivities and efficiencies and lower toxicities than analogues known heretofore.Type: ApplicationFiled: September 12, 2012Publication date: March 21, 2013Inventors: Lenka ZAHAJSKA, Jan Hanus, Lukas Spichal, Jiri Voller, Miroslav Strnad
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Publication number: 20130040908Abstract: Substitution derivatives of N6-benzyladenosine-5?-monophosphate of the general formula I, wherein (R)n represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising C1 to C8 alkyl, C1 to C8 alkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. A Method for their preparation, their use as medicaments and in other applications, and a therapeutic composition containing these derivatives is also disclosed.Type: ApplicationFiled: April 28, 2011Publication date: February 14, 2013Applicants: BIOAPEX, S.R.O., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Marek Zatloukal, Karel Dolezal, Jiri Voller, Lukas Spichal, Miroslav Strnad
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Publication number: 20110230503Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.Type: ApplicationFiled: May 26, 2011Publication date: September 22, 2011Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
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Patent number: 7960397Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the following general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for application to mammalian cells, and especially human skin cells, in order to improve the cosmetic appearance of the mammalian cells, especially human skin.Type: GrantFiled: December 28, 2007Date of Patent: June 14, 2011Assignee: Institute of Experimental Botany, Academy of Sciences of the Czech RepublicInventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
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Publication number: 20100240537Abstract: The invention relates to 6-(alkylbenzylamino)purine derivatives of the general formula I for use as cytokinin receptor antagonists, wherein R1 is selected from the group comprising hydroxyl, amino, nitro, thio and alkyl group, and R2 denotes one to four alkyl groups. The invention also relates to preparations containing these derivatives.Type: ApplicationFiled: October 3, 2008Publication date: September 23, 2010Inventors: Lukas Spichal, Igor Popa, Jiri Voller, Karel Dolezal, Miroslav Strnad, Tomas Werner, Thomas Schmulling
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Publication number: 20090170879Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.Type: ApplicationFiled: December 28, 2007Publication date: July 2, 2009Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino