Abstract: A method and apparatus for encoding a geographic location region as well as a method and apparatus for establishing an encoding model, which relate to big data and deep learning technologies in the field of artificial intelligence technologies are disclosed. An implementation includes: determining a to-be-encoded geographic location region; acquiring at least one kind of geographic function information and at least one kind of surface-feature distribution information of the geographic location region; and inputting the acquired geographic function information and the acquired surface-feature distribution information into an encoding model, the encoding model performing embedding on the geographic function information and the surface-feature distribution information, and fusing vector representations obtained by the embedding to obtain an encoding result of the geographic location region.

Abstract: The present disclosure provides a speech interaction method, apparatus, device and computer storage medium and relates to the field of artificial intelligence. A specific implementation solution is as follows: performing speech recognition and demand analysis for a first speech instruction input by a user; performing demand prediction for the first speech instruction if the demand analysis fails, to obtain at least one demand expression; returning at least one of the demand expression to the user in a form of a question; performing a service response with a demand analysis result corresponding to the demand expression confirmed by the user, if a second speech instruction confirming at least one of the demand expression is received from the user. The present disclosure can efficiently improve the user's interaction efficiency and enhance the user's experience.

Abstract: A method and apparatus for acquiring point of interest (POI) state information are suggested, which relate to a big data technology in the technical field of artificial intelligence. A specific implementation scheme involves: acquiring a text including POI information within a preset period from the Internet; and recognizing the text by using a pre-trained POI state recognition model, to obtain a two-tuple in the text, the two-tuple including a POI name and POI state information corresponding to the POI name.

Abstract: Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia?) or (Ib), as described herein.

Abstract: Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia?) or (Ib), as described herein.

Abstract: The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2, and Y are as defined herein. Methods of preparing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds in the treatment of viral infections such as influenza are also provided.

Abstract: The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.

Abstract: The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2, and Y are as defined herein. Methods of preparing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds in the treatment of viral infections such as influenza are also provided.

Abstract: The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.

Abstract: The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.

Abstract: Compounds that function as lamprey attractants and methods.

Abstract: Compounds that function as lamprey attractants and methods.