Patents by Inventor Jo Klaveness

Jo Klaveness has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Contrast agents

Publication number: 20070014731

Abstract: The present invention provides contrast agents for use in diagnostic ultrasound studies comprising microbubbles of gas or a gas precursor encapsulated by non-proteinaceous crosslinked or polymerised amphiphilic moieties.

Type: Application

Filed: May 17, 2006

Publication date: January 18, 2007

Inventors: Jo Klaveness, Hanno Priebe, Pal Rongved, Lars Stubberud
Contrast agents

Publication number: 20070003485

Abstract: The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.

Type: Application

Filed: June 6, 2006

Publication date: January 4, 2007

Inventors: Jo Klaveness, Pal Rongved, Per Strande
Pharmaceutical compositions comprising an active agent and chitosan for sustained drug release or mucoadhesion

Publication number: 20060293216

Abstract: The invention provides a pharmaceutical composition comprising a physiologically active agent and a release sustaining or mucoadhesive agent, characterized in that said release sustaining or mucoadhesive agent comprises a chitosan having a FA of from 0.25 to 0.80.

Type: Application

Filed: February 6, 2004

Publication date: December 28, 2006

Applicant: ADVANCED BIOPOLYMERS AS

Inventors: Jo Klaveness, Etnar Mustaparta, Bjarne Brudeli, Olaw Smidsrod, Kjell Varum
Optical imaging of colorectal cancer

Publication number: 20060292078

Abstract: The invention provides contrast agents for optical imaging of colorectal cancer (CRC) in patients. The contrast agents may be used in diagnosis of CRC, for follow up of progress in disease development, and for follow up of treatment of CRC. Further, the invention provides methods for optical imaging of CRC in patients.

Type: Application

Filed: September 28, 2004

Publication date: December 28, 2006

Inventors: Jo Klaveness, Edwin Johannesen, Helge Tolleshaug
Bone cement compositions

Publication number: 20060270750

Abstract: The present invention provides a bone cement comprising in admixture a monomer-containing liquid portion and a particulate polymer portion, wherein at least one of the portions comprises a dissolved nonpolymerizable organoiodine compound.

Type: Application

Filed: April 5, 2004

Publication date: November 30, 2006

Applicant: TA CONTRAST AB

Inventors: Torsten Almen, Jo Klaveness, Bjarne Brudeli
Chitosan foodstuff

Publication number: 20060240168

Abstract: The invention provides a foodstuff comprising a nutritional food substance and a chitosan having an FA value of at least 0.25.

Type: Application

Filed: February 6, 2004

Publication date: October 26, 2006

Inventors: Jo Klaveness, Einar Mustaparta, Bjarne Brudeli, Olav Smidsrod, Kjell Varum
Peroxide compositions

Publication number: 20060161121

Abstract: A kit comprising: a sealed container containing a ready-to-use skin bleaching composition including an emulsion containing 2 to 6% wt of a peroxide bleaching agent selected from hydrogen peroxide, organic peracids and salts thereof, hydrogen peroxide adducts, and metal peroxides, percarbonates and perborates; and instructions for the use of the composition to bleach chemically tanned skin.

Type: Application

Filed: February 6, 2004

Publication date: July 20, 2006

Applicant: DEHLI-CLEVE COLLECTION AS

Inventors: Jo Klaveness, Thomas Cleve, Kenneth Finstad, Bjame Brudeli
Light imaging contrast agents

Patent number: 7014839

Abstract: The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

Type: Grant

Filed: November 1, 2002

Date of Patent: March 21, 2006

Assignee: Amersham Health AS

Inventors: Jo Klaveness, Bjorn Fuglaas, Pål Rongved, Edvin Johannesen, Paul Mark Henrichs, Wolfgang Hans Heinrich Gunther, Edward Richard Bacon, John Luke Toner, Gregory Lynn McIntire, Vinay C. Desai
Contrast agents

Publication number: 20050232865

Abstract: The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.

Type: Application

Filed: February 10, 2005

Publication date: October 20, 2005

Inventors: Jo Klaveness, Pal Rongved, Per Strande
Contrast agents

Publication number: 20050201942

Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

Type: Application

Filed: March 4, 2005

Publication date: September 15, 2005

Inventors: Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
Contrast agents

Publication number: 20050201930

Abstract: The invention provides a composition of matter of formula I V-L-R ??(I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (eg 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

Type: Application

Filed: April 18, 2005

Publication date: September 15, 2005

Inventors: Jo Klaveness, Anne Naevestad, Alan Cuthbertson
Double esters

Publication number: 20050203181

Abstract: The invention provides acyloxymethyl esters of C6-14 alkane-dicarboxylic acids, or physiologically tolerable salts or esters thereof, for use in medicine as therapeutic or prophylactic agents.

Type: Application

Filed: November 22, 2002

Publication date: September 15, 2005

Inventor: Jo Klaveness
Contrast agents

Publication number: 20050196342

Abstract: Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure, with the proviso that the surfactant is not a C10-20 fatty acid, are disclosed. Processes for preparing contrast agents also are disclosed.

Type: Application

Filed: February 10, 2005

Publication date: September 8, 2005

Inventors: Jo Klaveness, Pal Rongved, Lars Stubberud
Contrast agents

Patent number: 6921525

Abstract: The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g. 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

Type: Grant

Filed: February 21, 2003

Date of Patent: July 26, 2005

Assignee: Amersham Health AS

Inventors: Jo Klaveness, Anne Naevestad, Alan Cuthbertson
Use of particulate contrast agents in diagnostic imaging for studying physiological paramaters

Publication number: 20050136002

Abstract: The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physioloogical parameter.

Type: Application

Filed: September 21, 2004

Publication date: June 23, 2005

Inventors: Sigrid Fossheim, Jo Klaveness, Atle Bjornerud, Pal Rongved, Klaes Golman, Roald Skurtveit
NEW ESTERS OF 5-AMINOLEVULINIC ACID AND THEIR USE AS PHOTOSENSITIZING COMPOUNDS IN PHOTOCHEMOTHERAPY

Publication number: 20050107471

Abstract: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Type: Application

Filed: October 14, 2004

Publication date: May 19, 2005

Inventors: Karl Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjorseth, Jo Klaveness, Nils Nilsen, Jon Braenden, Aslak Godal
Functional acylglycerides

Patent number: 6891054

Abstract: The present invention relates to the field of human and animal nutrition, and in particular to certain novel compositions of conjugated linoleic acids (CLA). In particular, the present invention relates certain isomers of conjugated linoleic acids at either the SN1 and SN3 or SN2 positions of the acylglyceride molecule and another fatty acyl residue at the other of the SN1 and SN3 or SN2 positions of the acylglyceride molecule. These novel acylglyceride compositions containing conjugated linoleic acyl residues, medium chain fatty acyl residues, long chain fatty acyl residues, and ?3, ?6, and ?9 fatty acyl residues are efficacious as pharmaceutical compositions, animal feed additives, and human dietary supplements.

Type: Grant

Filed: December 1, 2003

Date of Patent: May 10, 2005

Assignee: Natural AS

Inventors: Asgeir Saebo, Jo Klaveness
Metal complex compounds

Publication number: 20050090653

Abstract: The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said metal complex compounds.

Type: Application

Filed: November 28, 2002

Publication date: April 28, 2005

Inventors: Jo Klaveness, Pal Rongved
Contrast agents

Publication number: 20050031543

Abstract: Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure, with the proviso that the surfactant is not a C10-20 fatty acid, are disclosed. Processes for preparing contrast agents also are disclosed.

Type: Application

Filed: April 7, 2004

Publication date: February 10, 2005

Inventors: Jo Klaveness, Pal Rongved, Lars Stubberud
Pyrazolidinol compounds

Patent number: 6852749

Abstract: The invention provides the use of an optionally hydroxy-protected 4-hydroxyo or hydroperoxy-3,5-dioxopyrazolidine or an equivalent wherein a pyrazolidine ring attached oxygen is replaced by a sulphur, or a physiologically acceptable salt thereof, for the manufacture of a medicament for use in therapy or prophylaxis. Additionally, the invention provides a method of combating HIV infection which comprises administering to an HIV-infected patient a T-lymphocyte growth suppressing agent, preferably a pyrazolidinol, in an amount sufficient to suppress T-lymphocyte growth in said patient for a period sufficient to reduce the T-lymphocyte concentration in lymph nodes in said patient by at least 25%, said administration being repeated at intervals of at least 3 months.

Type: Grant

Filed: June 29, 2000

Date of Patent: February 8, 2005

Inventors: Enok Tjøtta, Jo Klaveness

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