Patents by Inventor João Manuel De Oliveira Garcia Da Fonseca
João Manuel De Oliveira Garcia Da Fonseca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132963Abstract: A fluidic device, instrument, and method for processing a biological sample is disclosed herein. An example of the fluidic device includes structures (e.g., sample holder(s), reaction chamber(s), reagent storage zone(s), metering compartment(s), reaction well(s), detection well(s), channel(s), etc.) for efficiently processing sample components and providing expression levels of various biomarker components for characterization of a sample.Type: ApplicationFiled: October 23, 2023Publication date: April 25, 2024Inventors: Timothy Elisha Sweeney, João Manuel de Oliveira Garcia da Fonseca, Paul Michael Fleming, Anna Claire Passernig, Kevin Hu, Ragheb Mohamad Fawaz El Khaja
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Publication number: 20210063303Abstract: A detection system including a detection device and an assay device. The detection device includes a space for receiving an assay device, a drive arrangement engaging the assay device to rotate the assay device, a light source arranged to direct light towards the assay device, and a diffuser arranged to diffuse light from the light source. The diffuser is arranged between the light source and the space. The detection device includes a light receiver arranged to receive light from the light source that has passed through the assay device.Type: ApplicationFiled: September 4, 2018Publication date: March 4, 2021Applicant: BIOSURFIT, S.A.Inventors: José PEDRO SANTOS MANSO CÔRTE-REAL, José MIGUEL SILVA DO CARMO NOGUEIRA, André MIGUEL ALVES FARINHA, Alberto EDUARDO ARTILHEIRO FERREIRA, Tiago FILIPE PINTO SILVA, Mauro MIGUEL MELO RIBEIRO, Filipe DA CONCEIÇÃO FERNANDES THOMAZ,, João MANUEL DE OLIVEIRA GARCIA DA FONSECA,
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Publication number: 20200209146Abstract: A detection system including a detection device and an assay device. The detection device includes a space for receiving an assay device, a drive arrangement engaging the assay device to rotate the assay device, a light source arranged to direct light towards the assay device, and a diffuser arranged to diffuse light from the light source. The diffuser is arranged between the light source and the space. The detection device includes a light receiver arranged to receive light from the light source that has passed through the assay device.Type: ApplicationFiled: September 4, 2018Publication date: July 2, 2020Applicant: BIOSURFIT, S.A.Inventors: Sandro MIGUEL PINTO BORDEIRA, Mauro MIGUEL MELO RIBEIRO, Miguel TAVARES ALELUIA, Rui MIGUEL AFONSO GOMES DA FONSECA,, Tiago FILIPE PINTO SILVA, Milton JOSÉ SANTOS FERNANDES, Filipe DA CONCEIÇÃO FERNANDES THOMAZ,, João MANUEL DE OLIVEIRA GARCIA DA FONSECA,
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Patent number: 10684206Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.Type: GrantFiled: September 29, 2015Date of Patent: June 16, 2020Assignee: Biosurfit, S.A.Inventors: Francisco Correia De Matos Nolasco Lamas, João Manuel De Oliveira Garcia Da Fonseca, André Do Rosário Magalhães, José Pedro Santos Manso Co̊rte-Real, Ricardo Manuel Marques Caleiro Cabeça
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Patent number: 10684207Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.Type: GrantFiled: March 29, 2018Date of Patent: June 16, 2020Assignee: Biosurfit, S.A.Inventors: Francisco Correia De Matos Nolasco Lamas, João Manuel De Oliveira Garcia Da Fonseca, André Do Rosário Magalhães, José Pedro Santos Manso Côrte-Real, Ricardo Manuel Marquest Caleiro Cabeca
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Patent number: 10337982Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.Type: GrantFiled: July 25, 2017Date of Patent: July 2, 2019Assignee: Biosurfit, S.A.Inventor: João Manuel de Oliveira Garcia Da Fonseca
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Patent number: 10330589Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.Type: GrantFiled: March 22, 2018Date of Patent: June 25, 2019Assignee: Biosurfit, S.A.Inventor: João Manuel de Oliveira Garcia Da Fonseca
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Patent number: 10307756Abstract: A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. In some embodiments, the microfluidic device comprises a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.Type: GrantFiled: March 22, 2018Date of Patent: June 4, 2019Assignee: Biosurfit, S.A.Inventors: Ricardo Manuel Marques Caleiro Cabeça, André Do Rosário Magalhães, Andreia Andrade Dos Santos, Sandra Cristina Sarmento Donato Dos Santos E Silva, João Manuel De Oliveira Garcia Da Fonseca
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Publication number: 20180217043Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.Type: ApplicationFiled: March 29, 2018Publication date: August 2, 2018Inventors: Francisco CORREIA DE MATOS NOLASCO LAMAS, João MANUEL DE OLIVEIRA GARCIA DA FONSECA, André DO ROSÁRIO MAGALHÃES, José PEDRO SANTOS MANSO CÔRTE-REAL, Ricardo Manuel Marquest Caleiro CABECA
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Publication number: 20180207636Abstract: A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. In some embodiments, the microfluidic device comprises a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.Type: ApplicationFiled: March 22, 2018Publication date: July 26, 2018Inventors: Ricardo Manuel MARQUES CALEIRO CABEÇA, André DO ROSÁRIO MAGALHÃES, Andreia ANDRADE DOS SANTOS, Sandra Cristina SARMENTO DONATO DOS SANTOS E SILVA, João Manuel DE OLIVEIRA GARCIA DA FONSECA
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Publication number: 20180209896Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.Type: ApplicationFiled: March 22, 2018Publication date: July 26, 2018Inventor: João Manuel de Oliveira Garcia Da Fonseca
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Patent number: 9933348Abstract: A device is disclosed for centrifugally driving liquid flow to sequentially dispense aliquots from a reservoir while the device rotates. Also disclosed is a method and system for analyzing a liquid to derive an indicator of sedimentation rate of the liquid using sequential aliquoting, using the disclosed device in some embodiments. A particular application is the analysis of blood samples, including sedimentation rate and hematocrit.Type: GrantFiled: December 7, 2012Date of Patent: April 3, 2018Assignee: Biosurfit, S.A.Inventors: Nuno Alexandre Esteves Reis, Joao Manuel De Oliveira Garcia Da Fonseca
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Publication number: 20180085754Abstract: A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. The microfluidic device can include a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.Type: ApplicationFiled: June 17, 2016Publication date: March 29, 2018Applicant: BIOSURFIT, S.A.Inventors: Ricardo Manuel MARQUES CALEIRO CABEÇA, André DO ROSÁRIO MAGALHÃES, Andreia ANDRADE DOS SANTOS, Sandra Cristina SARMENTO DONATO DOS SANTOS E SILVA, João Manuel DE OLIVEIRA GARCIA DA FONSECA,
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Patent number: 9914120Abstract: A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry reagents for reaction with the sample as the sample passes through the connection conduit. Specific embodiments include devices arranged for treating a blood sample, in particular lysing and staining the sample. The liquid flow may be driven by capillary effect. The device may further include liquid handling structures arranged for centrifugally driven liquid flow, for example to meter a volume of sample and separate the sample into phases by centrifugation.Type: GrantFiled: March 12, 2013Date of Patent: March 13, 2018Assignee: Biosurfit S.A.Inventors: João Manuel De Oliveira Garcia Da Fonseca, Ricardo Cabeça
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Publication number: 20180017483Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.Type: ApplicationFiled: July 25, 2017Publication date: January 18, 2018Inventor: João Manuel de Oliveira Garcia Da Fonseca
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Publication number: 20170307514Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.Type: ApplicationFiled: October 6, 2015Publication date: October 26, 2017Applicant: BIOSURFIT S.A.Inventor: João MANUEL DE OLIVEIRA GARCIA DA FONSECA
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Publication number: 20170212028Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.Type: ApplicationFiled: September 29, 2015Publication date: July 27, 2017Applicant: BIOSURFIT S.A.Inventors: Francisco CORREIA DE MATOS NOLASCO LAMAS, João MANUEL DE OLIVEIRA GARCIA DA FONSECA, André DO ROSÁRIO MAGALHÃES, José PEDRO SANTOS MANSO CÔRTE-REAL
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Patent number: 9632022Abstract: The disclosure relates to processing SPR signals, in particular signals obtained by illuminating a conductive surface with light at two wavelengths. Processing SPR signals can involve processing a first and second signal indicative of an intensity of light, received from a conductive layer at which SPR has occurred, as a function of angle of incidence, reflection or diffraction at the layer. The first and second signals each have two dips corresponding to a respective wavelength of the light at a respective angle at which surface plasmon resonance occurs for the respective wavelength and a peak between the two dips. The processing includes deriving a first and second value of a quantity indicative of signal magnitudes in the region of the peak. The first and second values can be compared to detect a change in refractive index at the layer after the first signal and before the second signal was captured.Type: GrantFiled: March 5, 2013Date of Patent: April 25, 2017Assignee: Biosurfit S.A.Inventor: Joao Manuel De Oliveira Garcia Da Fonseca
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Publication number: 20150109614Abstract: The disclosure relates to processing SPR signals, in particular signals obtained by illuminating a conductive surface with light at two wavelengths. Processing SPR signals can involve processing a first and second signal indicative of an intensity of light, received from a conductive layer at which SPR has occurred, as a function of angle of incidence, reflection or diffraction at the layer. The first and second signals each have two dips corresponding to a respective wavelength of the light at a respective angle at which surface plasmon resonance occurs for the respective wavelength and a peak between the two dips. The processing includes deriving a first and second value of a quantity indicative of signal magnitudes in the region of the peak. The first and second values can be compared to detect a change in refractive index at the layer after the first signal and before the second signal was captured.Type: ApplicationFiled: March 5, 2013Publication date: April 23, 2015Inventor: Joao Manuel De Oliveira Garcia Da Fonseca
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Publication number: 20150085275Abstract: Disclosed are methods and devices for photometric measurements of a liquid sample. The methods and devices use one or more diffractive reflective surfaces to enable a light beam incident on a measurement chamber to be steered so as to be reflected inside the measurement chamber to achieve relatively long optical paths in the measurement chamber. The liquid sample may be blood or blood serum. The measurement chamber may be provided in a microfluidic device, for example a centrifugal microfluidic device. Some embodiments enable multiplexing of different wavelengths or path lengths. Some embodiments make use of multiple returned beams to determine the position and/or orientation of the measurement chamber.Type: ApplicationFiled: November 29, 2012Publication date: March 26, 2015Inventor: Joäo Manuel De Oliveira Garcia Da Fonseca