Patents by Inventor Joachim Bernhard
Joachim Bernhard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220354744Abstract: The invention relates to a system with a seal between a manifold and a liquid container in which a sealing without an elastomer material is used, wherein the sealing properties of the seal are independent of the rotational position of the manifold in relation to the containerType: ApplicationFiled: November 10, 2020Publication date: November 10, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Heiko Kalbfell, Joachim Bernhard
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Patent number: 11426737Abstract: A waste disposal system for the disposal of consumables through a waste chute into a waste container includes a waste chute having a first opening and a second opening, wherein the first opening is situated outside the waste container and the second opening opens toward the waste container. The first opening and the second opening are arranged at a first distance from one another, wherein the waste chute includes a plurality of self-resetting lamellae for the partial or complete closure of the openings. The lamellae form at least two lamella annuli arranged at a second distance above one another, wherein at least one first lamella annulus closes the first opening and at least one second lamella annulus closes the second opening, and the second distance between the lamella annuli is at least one third, preferably at least half and particularly preferably at least three quarters of the first distance.Type: GrantFiled: February 14, 2020Date of Patent: August 30, 2022Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Heiko Kalbfell, Joachim Bernhard
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Publication number: 20200269251Abstract: A waste disposal system for the disposal of consumables through a waste chute into a waste container includes a waste chute having a first opening and a second opening, wherein the first opening is situated outside the waste container and the second opening opens toward the waste container. The first opening and the second opening are arranged at a first distance from one another, wherein the waste chute includes a plurality of self-resetting lamellae for the partial or complete closure of the openings. The lamellae form at least two lamella annuli arranged at a second distance above one another, wherein at least one first lamella annulus closes the first opening and at least one second lamella annulus closes the second opening, and the second distance between the lamella annuli is at least one third, preferably at least half and particularly preferably at least three quarters of the first distance.Type: ApplicationFiled: February 14, 2020Publication date: August 27, 2020Inventors: Heiko Kalbfell, Joachim Bernhard
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Patent number: 10739363Abstract: The present invention lies in the field of automated analyzers and relates to a method for mixing liquids in liquid containers. The arrangement for automated mixing comprises a shaking device and a gripper which is connected by way of a flexible connecting element to a transfer arm and which serves for receiving a liquid container. The coupling of gripper and shaking device is realized by way of an eccentrically movable coupling pin and a coupling hole provided for this purpose.Type: GrantFiled: March 9, 2017Date of Patent: August 11, 2020Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Joachim Bernhard, Christian Verhalen
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Publication number: 20180079825Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1.Type: ApplicationFiled: March 31, 2017Publication date: March 22, 2018Inventors: NEIL R. CASHMAN, AVIJIT CHAKRABARTTY, RISHI RAKHIT, JOACHIM BERNHARD OSTERMANN
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Publication number: 20170261525Abstract: The present invention lies in the field of automated analyzers and relates to a method for mixing liquids in liquid containers. The arrangement for automated mixing comprises a shaking device and a gripper which is connected by way of a flexible connecting element to a transfer arm and which serves for receiving a liquid container. The coupling of gripper and shaking device is realized by way of an eccentrically movable coupling pin and a coupling hole provided for this purpose.Type: ApplicationFiled: March 9, 2017Publication date: September 14, 2017Inventors: Joachim Bernhard, Christian Verhalen
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Patent number: 9637552Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1.Type: GrantFiled: June 10, 2014Date of Patent: May 2, 2017Assignee: ProMIS Neurosciences Inc.Inventors: Neil R. Cashman, Avijit Chakrabartty, Rishi Rakhit, Joachim Bernhard Ostermann
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Patent number: 9395381Abstract: The invention relates to a rotatable device (1) for transporting reaction vessels in an automatic analysis apparatus, said device (1) comprising a circular base plate (16), and a number of holders (2) which are connected to the base plate (16), are preferably made of a plastic and comprise the receiving positions (4, 6) for the reaction vessels.Type: GrantFiled: January 9, 2014Date of Patent: July 19, 2016Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBHInventors: Joachim Bernhard, Joerg Filzinger, Hugo Wilmes
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Publication number: 20140348822Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1.Type: ApplicationFiled: June 10, 2014Publication date: November 27, 2014Inventors: Neil R. Cashman, Avijit Chakrabartty, Rishi Rakhit, Joachim Bernhard Ostermann
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Patent number: 8778885Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1.Type: GrantFiled: June 8, 2011Date of Patent: July 15, 2014Assignee: Amorfix Life Sciences Ltd.Inventors: Neil R. Cashman, Avijit Chakrabartty, Rishi Rakhit, Joachim Bernhard Ostermann
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Publication number: 20140193300Abstract: The invention relates to a rotatable device (1) for transporting reaction vessels in an automatic analysis apparatus, said device (1) comprising a circular base plate (16), and a number of holders (2) which are connected to the base plate (16), are preferably made of a plastic and comprise the receiving positions (4, 6) for the reaction vessels.Type: ApplicationFiled: January 9, 2014Publication date: July 10, 2014Applicant: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBHInventors: Joachim Bernhard, Joerg Filzinger, Hugo Wilmes
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Patent number: 8714381Abstract: A closure device including a first and second closure element, the first closure element, which has an opening, being mounted on the opening of a container to be closed and the second closure element being movably connectable to the first closure element, the first closure element of the device having on the bottom surface facing the container a raised edge, which encircles the opening and has a sharp-edged region and a blunt region.Type: GrantFiled: August 23, 2011Date of Patent: May 6, 2014Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Joachim Bernhard, Joerg Filzinger, Hugo Wilmes
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Patent number: 8709422Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2).Type: GrantFiled: December 24, 2010Date of Patent: April 29, 2014Assignee: Amorfix Life Sciences Ltd.Inventors: Neil R. Cashman, Joachim Bernhard Ostermann, Avijit Chakrabartty, Rishi Rakhit
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Publication number: 20120048861Abstract: The invention relates to closure element and a re-closable two-part closure device for a reagent container, which are suitable, in particular, for the closure of light-sensitive reagents and intended for use in automatic analysis devices.Type: ApplicationFiled: August 23, 2011Publication date: March 1, 2012Applicant: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBHInventors: Joachim Bernhard, Joerg Filzinger, Hugo Wilmes
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Publication number: 20110305701Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1.Type: ApplicationFiled: June 8, 2011Publication date: December 15, 2011Inventors: Neil R. Cashman, Joachim Bernhard Ostermann, Avijit Chakrabartty, Rishi Rakhit
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Publication number: 20110212097Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2).Type: ApplicationFiled: December 24, 2010Publication date: September 1, 2011Inventors: Neil R. Cashman, Joachim Bernhard Ostermann, Avijit Chakrabartty, Rishi Rakhit
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Publication number: 20080206251Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2).Type: ApplicationFiled: September 5, 2007Publication date: August 28, 2008Inventors: Neil R. Cashman, Joachim Bernhard Ostermann, Avijit Chakrabartty, Rishi Rakhit
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Publication number: 20030129760Abstract: The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.Type: ApplicationFiled: November 13, 2002Publication date: July 10, 2003Inventors: Frank Reinaldo Morales Aguilera, Denis Faubert, Marguerite Boulos, John Shing-Chun Tsang, Michael Hu, Joachim Bernhard Ostermann, Paul Edward Kearney, Pierre Thibault