Patents by Inventor Joachim Graeser

Joachim Graeser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of dronedarone intermediates
    Patent number: 8658808
    Abstract: A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: February 25, 2014
    Assignee: Sanofi
    Inventors: Gerhard Kretzschmar, Volker Kraft, Kai Rossen, Joachim Graeser
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20140005392
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: Sanofi
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives
    Patent number: 8546567
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: October 1, 2013
    Assignee: Sanofi
    Inventors: Joachim Graeser, Guenter Billen, Adolf Linkies, Tobias Metzenthin
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20120271051
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 25, 2012
    Applicant: SANOFI
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives
    Patent number: 8232395
    Abstract: This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 31, 2012
    Assignee: Sanofi
    Inventors: Joachim Graeser, Guenter Billen, Adolf Linkies, Tobias Metzenthin
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20080214813
    Abstract: This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.
    Type: Application
    Filed: December 3, 2007
    Publication date: September 4, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Synthesis of 2-chloromethyl-6-methylbenzoic ester
    Patent number: 6989462
    Abstract: A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 groups may be replaced by —O—. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: January 24, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Claus-Jürgen Maier, Tobias Metzenthin, Joachim Graeser, Richard Bicker, Javier Manero
  • Synthesis of 2-chloromethyl-6-methylbenzoic ester
    Publication number: 20040192956
    Abstract: A process is described for preparing compounds of formula (I) 1
    Type: Application
    Filed: March 18, 2004
    Publication date: September 30, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Claus-Jurgen Maier, Tobias Metzenthin, Joachim Graeser, Richard Bicker, Javier Manero