Patents by Inventor Joachim Herz
Joachim Herz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230123187Abstract: The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.Type: ApplicationFiled: September 22, 2022Publication date: April 20, 2023Inventors: Joachim Herz, Yinyuan Ding, Xunde Xian, Linzhang Huang, Chieko Mineo, Philip Shaul, Laurent Calvier
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Patent number: 11472888Abstract: The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.Type: GrantFiled: May 14, 2020Date of Patent: October 18, 2022Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Joachim Herz, Yinyuan Ding, Xunde Xian, Linzhang Huang, Chieko Mineo, Philip Shaul, Laurent Calvier
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Publication number: 20210017291Abstract: The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.Type: ApplicationFiled: May 14, 2020Publication date: January 21, 2021Inventors: Joachim Herz, Yinyuan Ding, Xunde Xian, Linzhang Huang, Chieko Mineo, Philip Shaul, Laurent Calvier
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Patent number: 10683366Abstract: The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.Type: GrantFiled: September 23, 2016Date of Patent: June 16, 2020Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Joachim Herz, Yinyuan Ding, Xunde Xian, Linzhang Huang, Chieko Mineo, Philip Shaul, Laurent Calvier
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Patent number: 10149836Abstract: The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.Type: GrantFiled: March 20, 2015Date of Patent: December 11, 2018Assignee: The Board of Regents of the University of Texas SystemInventors: Joachim Herz, Gang Yu, Bruce Posner, Basar Cenik
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Publication number: 20180273637Abstract: The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.Type: ApplicationFiled: September 23, 2016Publication date: September 27, 2018Inventors: Joachim Herz, Yinyuan Ding, Xiang Xunde, Linzhang Huang, Chieko Mineo, Philip Shaul
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Publication number: 20170172987Abstract: The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.Type: ApplicationFiled: March 20, 2015Publication date: June 22, 2017Inventors: Joachim HERZ, Gang YU, Bruce POSNER, Basar CENIK
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Patent number: 8530516Abstract: Cycling of ApoE4 isoform is promoted in a person in need thereof by contacting the person with an effective amount of a pharmaceutically-acceptable modulator of intracellular ApoE4 transport vesicle pH.Type: GrantFiled: December 7, 2010Date of Patent: September 10, 2013Assignee: Board of Regents, The University of Texas SystemInventors: Joachim Herz, Xunde Xian, Yuan Yang
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Publication number: 20110136832Abstract: Cycling of ApoE4 isoform is promoted in a person in need thereof by contacting the person with an effective amount of a pharmaceutically-acceptable modulator of intracellular ApoE4 transport vesicle pH.Type: ApplicationFiled: December 7, 2010Publication date: June 9, 2011Inventors: Joachim Herz, Xunde Xian, Yuan Yang
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Patent number: 7192714Abstract: The invention provides methods and compositions for modeling and detecting LDL receptor transmembrane signaling by detecting proteolysis of an LDL receptor transmembrane domain. The method comprises the steps of: a) providing a sample comprising a cell membrane comprising (i) a polypeptide comprising an LDL receptor transmembrane domain fused to a C-terminal tail, and (ii) a protease which specifically cleaves the domain and thereby releases the tail from the membrane; b) incubating the sample under conditions wherein the protease cleaves the domain and thereby releases the tail from the membrane; and c) detecting a resultant released tail.Type: GrantFiled: October 12, 2001Date of Patent: March 20, 2007Assignee: Board of Regents, The University of Texas SystemInventors: Joachim Herz, Petra May
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Publication number: 20060211039Abstract: The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with an LDL receptor interaction domain, by (a) introducing a predetermined stress into a system which provides a physical interaction of an LDL receptor binding polypeptide with an LDL receptor intracellular binding polypeptide interaction domain, whereby the system provides a stress-biased interaction of the binding polypeptide and the interaction domain, wherein the absence of the stress, the system provides a unbiased interaction of the binding polypeptide and the interaction domain; and (b) detecting the stress-biased interaction of the binding polypeptide and the interaction domain, wherein the binding polypeptide is selected from SEMCAP-1, JIP-1, PSD-95, JIP-2, Talin, OMP25, CAPON, PIP4,5 kinase, Na channel brain 3, Mint1, ICAP-1 and APC subunit1Type: ApplicationFiled: May 30, 2006Publication date: September 21, 2006Inventors: Joachim Herz, Michael Gotthardt
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Patent number: 7056688Abstract: The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with an LDL receptor interaction domain, by (a) introducing a predetermined stress into a system which provides a physical interaction of an LDL receptor binding polypeptide with an LDL receptor intracellular binding polypeptide interaction domain, whereby the system provides a stress-biased interaction of the binding polypeptide and the interaction domain, wherein the absence of the stress, the system provides a unbiased interaction of the binding polypeptide and the interaction domain; and (b) detecting the stress-biased interaction of the binding polypeptide and the interaction domain, wherein the binding polypeptide is selected from SEMCAP-1, JIP-1, PSD-95, JIP-2, Talin, OMP25, CAPON, PIP4,5 kinase, Na channel brain 3, Mint1, ICAP-1 and APC subunitType: GrantFiled: August 1, 2002Date of Patent: June 6, 2006Assignee: Board of Regents, The University of Texas SystemInventors: Joachim Herz, Michael Gotthardt
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Publication number: 20030082640Abstract: The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with an LDL receptor interaction domain, by (a) introducing a predetermined stress into a system which provides a physical interaction of an LDL receptor binding polypeptide with an LDL receptor intracellular binding polypeptide interaction domain, whereby the system provides a stress-biased interaction of the binding polypeptide and the interaction domain, wherein the absence of the stress, the system provides a unbiased interaction of the binding polypeptide and the interaction domain; and (b) detecting the stress-biased interaction of the binding polypeptide and the interaction domain, wherein the binding polypeptide is selected from SEMCAP-1, JIP-1, PSD-95, JIP-2, Talin, OMP25, CAPON, PIP4,5 kinase, Na channel brain 3, Mint1, ICAP-1 and APC subunit1Type: ApplicationFiled: August 1, 2002Publication date: May 1, 2003Applicant: The University of Texas Board of RegentsInventors: Joachim Herz, Michael Gotthardt
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Publication number: 20030077672Abstract: The invention provides methods and compositions for modeling and detecting LDL receptor transmembrane signaling by detecting proteolysis of an LDL receptor transmembrane domain. The method comprises the steps of: a) providing a sample comprising a cell membrane comprising (i) a polypeptide comprising an LDL receptor transmembrane domain fused to a C-terminal tail, and (ii) a protease which specifically cleaves the domain and thereby releases the tail from the membrane; b) incubating the sample under conditions wherein the protease cleaves the domain and thereby releases the tail from the membrane; and c) detecting a resultant released tail.Type: ApplicationFiled: October 12, 2001Publication date: April 24, 2003Inventors: Joachim Herz, Petra May
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Patent number: 6428967Abstract: The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with an LDL receptor interaction domain, by (a) introducing a predetermined stress into a system which provides a physical interaction of an LDL receptor binding polypeptide with an LDL receptor intracellular binding polypeptide interaction domain, whereby the system provides a stress-biased interaction of the binding polypeptide and the interaction domain, wherein the absence of the stress, the system provides a unbiased interaction of the binding polypeptide and the interaction domain; and (b) detecting the stress-biased interaction of the binding polypeptide and the interaction domain, wherein the binding polypeptide is selected from SEMCAP-1, JIP-1, PSD-95, JIP-2, Talin, OMP25, CAPON, PIP4,5 kinase, Na channel brain 3, Mint1, ICAP-1 and APC subunit1Type: GrantFiled: May 1, 2000Date of Patent: August 6, 2002Assignee: Board of Regents, The University of Texas SystemInventors: Joachim Herz, Michael Gotthardt