Patents by Inventor Joana OLIVEIRA GAMA SOARES

Joana OLIVEIRA GAMA SOARES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS
    Publication number: 20210315866
    Abstract: The present application relates to compounds of formula I, which are (3S)- and (3R)-6,7-bis(Hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. The present application also relates to pharmaceutical compositions having the compounds and the use of these compounds in the treatment of conditions influenced by wild-type or mutant p53 forms. More specifically, these compounds represent a completely new chemical family of p53-activating agents and show a higher selectivity towards the p53-pathway compared to the reactivators of p53 currently under clinical trials. For some cancer types these compounds revealed to be more potent than the reactivators of p53 currently under clinical trials. In addition to these advantages, the presently disclosed compounds are not genotoxic and have no apparent undesirable toxic side effects.
    Type: Application
    Filed: May 2, 2019
    Publication date: October 14, 2021
    Inventors: Lucilia Helena ATAIDE SARAIVA, Joana Oliveira GAMA SOARES, Teresa Margarida VASCONCELOS DIAS DE PINHO E MELO, Helena Isabel NQGUEIRA RAMOS ROCHA
  • Tryptophanol-derived oxazoloisoindolinones: small-molecule P53 activators
    Patent number: 9732091
    Abstract: The present application discloses novel family of Tryptophanol-Derived Oxazoloisoindolinones for use in the treatment of p53 associated conditions, such as cancer. These compounds are p53 activators and may be used in pharmaceutical compositions, alone or in combination with other chemotherapeutic agents.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 15, 2017
    Assignees: UNIVERSIDADE DO PORTO, FACULDADE DE FARMACIA DA UNIVERSIDADE DE LISBOA
    Inventors: Lucilia Helena Ataide Saraiva, Maria Manuel Duque Vieira Marques Dos Santos, Nuno Alexandre Lousa Pereira, Clara Isabel Ferreira Pereira, Sara Gomes Moreira, Mariana Valencia Castanheira Ferreira Leao, Angelo Filipe Almeida Monteiro, Joana Oliveira Gama Soares
  • TRYPTOPHANOL-DERIVED OXAZOLOISOINDOLINONES: SMALL-MOLECULE P53 ACTIVATORS
    Publication number: 20160347765
    Abstract: The present application discloses novel family of Tryptophanol-Derived Oxazoloisoindolinones for use in the treatment of p53 associated conditions, such as cancer. These compounds are p53 activators and may be used in pharmaceutical compositions, alone or in combination with other chemoterapeutic agents.
    Type: Application
    Filed: June 26, 2014
    Publication date: December 1, 2016
    Inventors: Lucilia Helena ATAIDE SARAIVA, Maria Manuel DUQUE VIEIRA MARQUES DOS SANTOS, Nuno Alexandre LOUSA PEREIRA, Clara Isabel FERREIRA PEREIRA, Sara GOMES MOREIRA, Mariana Valencia CASTANHEIRA FERREIRA LEAO, Angelo Filipe ALMEIDA MONTEIRO, Joana OLIVEIRA GAMA SOARES