Patents by Inventor Joanna Marie Passmore
Joanna Marie Passmore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9481685Abstract: The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.Type: GrantFiled: October 2, 2009Date of Patent: November 1, 2016Assignee: GE Healthcare LimitedInventors: Harry John Wadsworth, Bo Shan, Dennis O'Shea, Joanna Marie Passmore, William John Trigg
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Patent number: 8790619Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.Type: GrantFiled: March 26, 2010Date of Patent: July 29, 2014Assignee: GE Healthcare LimitedInventors: Harry John Wadsworth, Bo Shan, Dennis O'Shea, Joanna Marie Passmore, William John Trigg, Amanda Ewan
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Patent number: 8501153Abstract: The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.Type: GrantFiled: September 13, 2010Date of Patent: August 6, 2013Assignee: GE Healthcare LimitedInventors: Radha Achanath, Srinath Balaji, Afsal M. Kadavilpparampu Mohamed, Umamaheshwar Mokkapati, Steven Fairway, Dimitrios Mantzilas, Dennis O'Shea, William John Trigg, Harry John Wadsworth, Joanna Marie Passmore, Bo Shan
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Patent number: 8202511Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: GrantFiled: October 10, 2008Date of Patent: June 19, 2012Assignee: GE Healthcare ASInventors: Ian Martin Newington, Duncan George Wynn, Veronique Morisson-Iveson, Joanna Marie Passmore
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Publication number: 20120020884Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.Type: ApplicationFiled: March 26, 2010Publication date: January 26, 2012Inventors: Harry John Wadsworth, Bo Shan, Dennis O'shea, Joanna Marie Passmore, William John Trigg, Amanda Ewan
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Publication number: 20110190618Abstract: The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.Type: ApplicationFiled: October 2, 2009Publication date: August 4, 2011Inventors: Harry John Wadsworth, Bo Shan, Dennis O' Shea, Joanna Marie Passmore, William John Trigg
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Publication number: 20110070161Abstract: The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.Type: ApplicationFiled: September 13, 2010Publication date: March 24, 2011Applicant: GE HEALTHCARE LIMITEDInventors: RADHA ACHANATH, SRINATH BALAJI, STEVEN FAIRWAY, AFSAL M. KADAVILPPARAMPU MOHAMED, DIMITRIOS MANTZILAS, UMAMAHESHWAR MOKKAPATI, DENNIS O'SHEA, JOANNA MARIE PASSMORE, BO SHAN, WILLIAM JOHN TRIGG, HARRY JOHN WADSWORTH
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Publication number: 20100221189Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds.Type: ApplicationFiled: October 10, 2008Publication date: September 2, 2010Inventors: Ian Martin Newington, Duncan George Wynn, Veronique Morisson-Iveson, Joanna Marie Passmore
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Publication number: 20080260651Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic N-heterocyclic central moiety such as pyrrolidine or piperidine heterocycles allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging, in particular in X-ray imaging, and to contrast media containing such compounds.Type: ApplicationFiled: April 15, 2008Publication date: October 23, 2008Applicant: GE HEALTHCARE ASInventors: Veronique Morisson-Iveson, Joanna Marie Passmore