Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

Abstract: A fully implantable nerve stimulation system includes an event-triggered, closed-loop control unit that detects physiological events from nerve signals and delivers stimulation pulses to a nerve to produce a desired physiological response. The stimulation system includes a low-noise, low-power nerve signal amplifier, accelerometers that detect position and a battery powered processor that selectively powers components in the system to detect physiological events and deliver stimulation pulses with a minimum of battery power.

Abstract: An implantable electrical connector includes a male portion and a female receptacle. The male portion includes a number of wires that terminate in a pattern of conductive areas. The male portion is inserted into a female receptacle and guides in the female receptacle limit the insertion of the male portion to a single direction. A locking mechanism such as a setscrew on the female receptacle forces conductive areas of the exposed conductors onto connecting pins within the female receptacle. The setscrew itself is electrically isolated from the conductive areas. Each pin in the female receptacle is surrounded by a rigid seal that engages a compressible insulating member under compression of the locking mechanism to prevent an electrical connection forming between adjacent pins in the connector.

Abstract: This invention relates to a system and methods for relieving phantomlimb pain in amputees, and for providing an amputee with sensory feedback from a prosthetic limb. The system employs implantable multichannel, multi-chambered interface structures, namely, nerve cuffs. The implanted nerve cuffs have electrodes which transmit electrical signals generated by a signal generator to nerves, recruiting certain neurons to send sensory signals to the cerebral cortex, suggesting sensory sensations to the amputee. Such signals can arise directly from the signal generator, approximating the train of signals seen by the cortex in a normally innervated limb, or can originate from sensors in a prosthetic limb.