Patents by Inventor Joaquin Diaz Alperi
Joaquin Diaz Alperi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9211270Abstract: The invention relates to a method for increasing the therapeutic efficacy of curcuminoids and analogs. More specifically, the invention relates to a method for increasing the therapeutic efficacy of systemically administered formulations that contain curcuminoids and the equivalent therapeutics thereof. The method is characterized in that together with the administration of the formulation the patient is irradiated with visible, and optionally ultraviolet, radiation during a treatment. The invention also relates to phototherapy devices that emit visible radiation over a surface area greater than 0.2 m2 with an irradiance of more than 2 mW/cm2, the devices being suitable for use in the treatment of proliferative diseases, particularly moderate-to-severe psoriasis or tumor processes.Type: GrantFiled: May 22, 2014Date of Patent: December 15, 2015Assignee: ASAC Compañia de Technologia e Invertigación, S.A.Inventors: Joaquin Diaz Alperi, Ana Adela Ramirez Bosca, August Bernd
-
Publication number: 20140257170Abstract: The invention relates to a method for increasing the therapeutic efficacy of curcuminoids and analogs. More specifically, the invention relates to a method for increasing the therapeutic efficacy of systemically administered formulations that contain curcuminoids and the equivalent therapeutics thereof. The method is characterized in that together with the administration of the formulation the patient is irradiated with visible, and optionally ultraviolet, radiation during a treatment. The invention also relates to phototherapy devices that emit visible radiation over a surface area greater than 0.2 m2 with an irradiance of more than 2 mW/cm2, the devices being suitable for use in the treatment of proliferative diseases, particularly moderate-to-severe psoriasis or tumor processes.Type: ApplicationFiled: May 22, 2014Publication date: September 11, 2014Applicant: ASAC Compañía de Biotecnología e Investigación, S.A.Inventors: Joaquin DIAZ ALPERI, Ana Adela RAMIREZ BOSCA, August BERND
-
Patent number: 8748494Abstract: The invention relates to a method for increasing the therapeutic efficacy of curcuminoids and analogs. More specifically, the invention relates to a method for increasing the therapeutic efficacy of systemically administered formulations that contain curcuminoids and the equivalent therapeutics thereof. The method is characterized in that together with the administration of the formulation the patient is irradiated with visible, and optionally ultraviolet, radiation during a treatment. The invention also relates to phototherapy devices that emit visible radiation over a surface area greater than 0.2 m2 with an irradiance of more than 2 mW/cm2, the devices being suitable for use in the treatment of proliferative diseases, particularly moderate-to-severe psoriasis or tumor processes.Type: GrantFiled: June 9, 2010Date of Patent: June 10, 2014Assignee: ASAC Compñia de Biotecnología e Investigación, S.A.Inventors: Joaquin Diaz Alperi, Ana Adela Ramirez Bosca, August Bernd
-
Publication number: 20100298444Abstract: The invention relates to a method for increasing the therapeutic efficacy of curcuminoids and analogs. More specifically, the invention relates to a method for increasing the therapeutic efficacy of systemically administered formulations that contain curcuminoids and the equivalent therapeutics thereof. The method is characterized in that together with the administration of the formulation the patient is irradiated with visible, and optionally ultraviolet, radiation during a treatment. The invention also relates to phototherapy devices that emit visible radiation over a surface area greater than 0.2 m2 with an irradiance of more than 2 mW/cm2, the devices being suitable for use in the treatment of proliferative diseases, particularly moderate-to-severe psoriasis or tumor processes.Type: ApplicationFiled: June 9, 2010Publication date: November 25, 2010Applicant: ASAC Compania de Biotecnologia e Investigacion S.A.Inventors: Joaquín DÍAZ ALPERI, Ana Adela RAMÍREZ BOSCÁ, August BERND
-
Patent number: 6841177Abstract: New pharmacological activities of Curcuma Longa extracts as antiproliferative and photosensitivisation agents and their use in proliferative diseases such as psoriasis, as reducers of plasmatic fibrinogen and the Apolipoprotein B/Apolipoprotein A-I quotient, without altering other coagulation parameters.Type: GrantFiled: September 21, 2000Date of Patent: January 11, 2005Assignee: ASAC Compania de Biotecnologia e Investigacion S.A.Inventors: Elisso Quintanilla Almagro, Ana Ramírez Bosca, August Bernd, José Pardo Zapata, Joaquin Diaz Alperi, David Pamies Mira, Miguel Angel Carrion Gutierrez, José Miguel Sempere Ortells
-
Publication number: 20040126442Abstract: This invention concerns to a topical pharmaceutical composition comprising an water soluble Curcuma extract, and suitable excipients for said topical administration; the process for obtaining said pharmaceutical compositions; the use of different Curcuma extracts as photosensitizing agents for the treatment of proliferative diseases; and the use of Curcuma extract or curcuminoids in combination with a radiation for the treatment of proliferative diseases on eukaryote cells.Type: ApplicationFiled: October 15, 2003Publication date: July 1, 2004Applicant: ASCA, COMPANIA DE BIOTECNOLOGIA E INVESTIGACION S.A.Inventors: Eliseo Quintanilla Almagro, Ana Ramirez Bosca, August Bernd, Jose Pardo Zapata, Joaquin Diaz Alperi, David Pamies Mira, Miguel Angel Carrion Gutierrez, Jose Miguel Sempere Ortells
-
Patent number: 6706293Abstract: Pharmaceutical composition with adhesion molecule expression regulating activity. The invention relates to a novel pharmaceutical application of a pharmaceutical composition exhibiting regulating activity of the expression of adhesion molecules integrins, selectins and immunoglobulins and its application as anti-inflammatory agent. Said pharmaceutical composition contains Anapsos, a water-soluble extract and a lipo-soluble extract of the rhizomes of Polypodium leucotomos as active substance in addition to acceptable excipients.Type: GrantFiled: June 10, 2002Date of Patent: March 16, 2004Assignee: Especialidades Farmaceuticas Centrum, S.A.Inventors: Eliseo Quintanilla Almagro, Joaquín Diaz Alperi
-
Patent number: 6699512Abstract: Hypericum perforatum L. Oleoresin, procedure for obtaining it and uses of it. A Hypericum perforatum L Oleoresin is describes that is stable over time on its Hyperforin and Hypericine content without adding preservatives; a procedure for obtaining the Oleoresin by extraction with low-polarity solvents, followed by purification; also its use as a regulator of the components of the extracellular matrix is described and its use for the manufacture of hydrosoluble gels containing Hypericum perforatum L Oleoresin.Type: GrantFiled: April 22, 2002Date of Patent: March 2, 2004Assignee: Asac, Compañia de Biotechnologia e Investigacion, S.A.Inventors: Eliseo Quintanilla Almagro, Ana Ramirez Bosca, August Abernd, José Pardo Zapata, Joaquín Diaz Alperi, David Pamies Mira, Miquel Angel Carrion Gutierrez
-
Patent number: 6676980Abstract: Procedure for obtaining Olea Europea extracts from Olea Europea leaves dried at less than 35° C. with alkanols at a low temperature and extract purification New pharmacological applications of Olea Europea extracts as an agent reinforcing cellular immunity and delayed hypersensitivity in healthy humans, activating and proliferating T-lymphocytes, Natural Killer cells, monocytes and granulocytes, and pro-inflammatory cytokins.Type: GrantFiled: March 8, 2002Date of Patent: January 13, 2004Assignee: Asac Compañia de Biotecnologia e Investigacion S.A.Inventors: Eliseo Quintanilla Almagro, Ginés Aviles Olmos, José Antonio Tovar Oliva, Joaquin Diaz Alperi, José Sempere Ortells, José Pardo Zapata
-
Publication number: 20030017217Abstract: Procedure for obtaining Olea Europea extracts from Olea Europea leaves dried at less than 35° C.Type: ApplicationFiled: March 8, 2002Publication date: January 23, 2003Inventors: Eliseo Quintanilla Almagro, Gines Aviles Olmos, Jose Antonio Tovar Oliva, Joaquin Diaz Alperi, Jose Sempere Ortells, Jose Pardo Zapata
-
Publication number: 20020197337Abstract: Hypericum Perforatum L. Oleoresin, procedure for obtaining it and uses of it. A Hypericum Perforatum L Oleoresin is describes that is stable over time on its Hyperforin and Hypericine content without adding preservatives; a procedure for obtaining the Oleoresin by extraction with low-polarity solvents, followed by purification; also its use as a regulator of the components of the extracellular matrix is described and its use for the manufacture of hydrosoluble gels containing Hypericum Perforatum L Oleoresin.Type: ApplicationFiled: April 22, 2002Publication date: December 26, 2002Inventors: Eliseo Quintanilla Almagro, Ana Ramirez Bosca, August Abernd, Jose Pardo Zapata, Joaquin Diaz Alperi, David Pamies Mira, Miquel Angel Carrion Gutierrez
-
Patent number: 6440468Abstract: A process for obtaining the apolar extract comprises: (a) extracting the rhizomes with an organic solvent; (b) filtration and evaporation to dryness of the extract; (c) dissolution of the oleoresin obtained in hot conditions, precipitation while allowing to cool down and filtration of the solid; (d) drying and recrystallizing the solid in order to obtain a product having a purity in curcuminoids higher than 90%. Obtaining the polar extract comprises: (a′) extraction of the rhizomes with water at 50-70° C. and (b′) filtration and evaporation of the water. Application of the compositions and preparations as catchers of free radicals and antiageing agents, as well as reducing agents to reduce the plasma levels of lipid peroxides in human beings are disclosed.Type: GrantFiled: October 28, 1996Date of Patent: August 27, 2002Assignee: A.S.A.C. Pharmaceutical International, A.I.E.Inventors: Eliseo Quintanilla Almagro, Joaquin Diaz Alperi
-
Pharmaceutical composition of activity in the treatment of cognitive and/or neuroimmune dysfunctions
Patent number: 5601829Abstract: A pharmaceutical composition with beneficial effects in disorders which deal with cognitive, neurodegenerative and/or neuroimmune dysfunctions, especially the Alzheimer disease, characterized in that it comprises, as active ingredient, an isolated, natural hydrosoluble extract of the rhizome or leaves of Phlebodium decumanum, Polypodium aureum, Polypodium leucotomos, Polypodium vulgare, Polypodium trisereiale, Pteridium aquilinum, Dryopteris crassirhizoma and Cyathea taiwamiana, and the liposoluble fraction derivates of said extract, together with an acceptable pharmaceutical vehicle.Type: GrantFiled: May 3, 1995Date of Patent: February 11, 1997Assignee: Especialidades Farmaceuticas Centrum, S.A.Inventors: Eliseo Quintanilla Almagro, Joaquin Diaz Alperi