Abstract: A cap and Luer connector arrangement with an improved external seal is provided for a fluid transfer connector or fitting that has a nozzle with a surrounding annular collar located coaxially within a surrounding sealing lip. The cap includes a structure of resilient material which defines an end wall, an annular, inner sleeve extending from the end wall, and an annular, outer skirt extending from the end wall to define an annular receiving channel between the outer skirt and the inner sleeve. At least a portion of the inner sleeve has an inner surface for sealingly engaging the nozzle. A distal end of the outer skirt includes a seal region having a V-shaped cross-sectional crevice. The Luer connector sealing lip and seal region are distorted when the sealing lip is received into the crevice during initial screwed-on installation of the cap to the Luer connector, forming an external seal.

Abstract: Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom.

Abstract: The present invention provides a method and apparatus for sterilizing a pharmaceutical composition, the method comprising providing a sterilization system including a heat exchanger for elevating and then lowering the temperature of the fluid in a time period; measuring temperature at an input of the heat exchanger, measuring temperature at an output of the heat exchanger and measuring temperature at least one point in the heat exchanger intermediate to the input and output; calculating a coefficient of heat transfer for the sterilization system using the temperature measurements; calculating a degree of sterilization (F.sub.o) using the coefficient; and adjusting the temperature of the heat exchanger to minimize degradation of the pharmaceutical composition while maintaining an acceptable degree of sterilization.

Abstract: Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom.

Abstract: The present invention is directed to a method for the on-line sterile filling of a container with a sterile solution from a filling nozzle in a filling head. A container having an open end and a hollow body portion for receiving the sterile solution is provided. The container also includes an access passageway tube having first and second ends and a pierceable septum sealing the passageway at an intermediate position within the tube. The first open end of the access passageway tube is sealed in the open end of the container so as to close the hollow body portion of the container, which is then sterilized. Later, before on line filling, the second end of the access passageway tube is isolated from the surrounding environment by axially advancing and sealably seating the filling head at the second end of the access passageway tube. The isolated end of the access passageway tube is then sterilized for a time period sufficient to reduce the viable micro-organism population present to a predetermined level.

Abstract: An irrigation solution re-circulating system comprises a reservoir of irrigation solution, a solution supply line for joining the reservoir in fluid communication with a surgery site for delivering a controlled volume, pressure, and temperature of the irrigation solution to the surgery site, and a return line for further joining the surgery site in fluid communication with the reservoir. A pump, which is preferably non-hemolyzing, is connected to the return line for returning a controlled volume of the irrigation solution from the surgery site to the reservoir. The system further comprises at least one filter connected to the return line for removing contaminants from the irrigation solution prior to return to the reservoir to permit re-circulation of the solution without impairing endoscopic visualization of the surgery site, while providing solution for expanding the surgery site to permit performance of the attendant surgical procedure.

Abstract: A reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof.

Abstract: Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom.

Abstract: The present invention is directed to a device for sterile coupling and decoupling of a first solution system to a second solution system. The first system has a resealable member so as to allow access into the system. The device includes a housing for receiving the resealable member so as to provide a fluid tight cooperating engagement with the resealable member. A penetrable barrier is positioned in the housing across from the resealable member. A conduit in flow communication with the second system is adapted for sterile penetration of the barrier and the resealable member. An inlet and outlet duct provides a passageway between the barrier and the resealable member. The inlet is adapted for fluid flow from a source of sterilizing fluid and optionally a sterile rinsing fluid. The outlet duct receives the sterilizing fluid after is passes across and sterilizes the resealable member facing the barrier.

Abstract: The invention relates to a process for the production of a contact lens, which comprises coating a tool made of an inert material, having a curvature corresponding to that of one of the optical surfaces of the lens to be produced, with a layer of solid polymer, and machining the outer surface of said polymer to the desired curvature of the second surface of said lens while supported by said tool, and to a tool for carrying out such process.