Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A shoe sole assembly is made by drying and cutting a fiber gourd into a cylindrical configuration. The cylindrical gourd fiber is then expanded and pressed into a sheet of gourd fiber. The sheet of gourd fiber may then be cut into a number of shoe soles. An insole layer may further be secured to each shoe sole to form the shoe sole assembly.