Patents by Inventor Jochen Gatgens

Jochen Gatgens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR CULTURING CELLS IN ORDER TO PRODUCE SUBSTANCES
    Publication number: 20140329277
    Abstract: The invention concerns a method for culturing cells in order to produce substances. According to the invention a cell line producing substances is cultured while feeding a nutrient medium in such a manner that glucose limitation occurs in the culture solution. The degree of glucose limitation DGL=qGlc/qGlcmax (qGlc=observed current specific glucose consumption rate; qGlcmax=maximum known specific glucose consumption rate for these cells). DGL is between the limits 0 and 1, where 0 means complete limitation and 1 means no limitations or complete glucose excess. According to the invention DGL is larger or equal to the DGL which only leads to the maintenance of the cell and ?0.5.
    Type: Application
    Filed: January 21, 2014
    Publication date: November 6, 2014
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Thomas Link, Ruth Essers, Kerstin Zorner, Jochen Gatgens, Thomas Noll, Christian Wandrey
  • Method for culturing cells in order to produce substances
    Publication number: 20060127975
    Abstract: The invention concerns a method for culturing cells in order to produce substances. According to the invention a cell line producing substances is cultured while feeding a nutrient medium in such a manner that glucose limitation occurs in the culture solution. The degree of glucose limitation DGL=qGlc/qGlcmax (qGlc=observed current specific glucose consumption rate; qGlcmax=maximum known specific glucose consumption rate for these cells). DGL is between the limits 0 and 1, where 0 means complete limitation and 1 means no limitations or complete glucose excess. According to the invention DGL is larger or equal to the DGL which only leads to the maintenance of the cell and ?0.5.
    Type: Application
    Filed: November 7, 2003
    Publication date: June 15, 2006
    Inventors: Thomas Link, Ruth Essers, Kerstin Zorner, Jochen Gatgens, Thomas Noll, Christian Wandrey
  • Glycosylation using GalNac-T4 transferase
    Patent number: 6465220
    Abstract: The use of human polypeptide N-acetylgalactosaminytransferase T-4 (GalNAc-T4) to glycosylate substrates is disclosed. The action of GalNAc-T4 can complement the activities of GalNAc-T1, -T2 and -T3. The glycosylated substrates are useful in preparation of vaccines and anti-inflammatory agents. A method of producing the soluble form of the enzyme is also disclosed.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 15, 2002
    Assignee: GlycoZym ApS
    Inventors: Frau Helle Hassan, Henrik Clausen, Eric Paul Bennett, Detlef Eisenkrätzer, Jochen Gätgens