Abstract: A normally closed valve for microfluidic components includes a polymer substrate and a polymer membrane film arranged on the polymer substrate. The polymer substrate has a first chamber, a second chamber, and a fluidic barrier element configured to separate the first chamber from the second chamber. The first chamber is fluidically coupled to the second chamber by the polymer membrane film, and, in an initial configuration, a connection of the polymer membrane film to the fluidic barrier element prevents a fluidic communication of the first chamber to the second chamber. The first chamber is at least partially filled with a substance in the initial configuration, and a transfer of the substance from the first chamber into the second chamber takes place by applying a pressure to the substance. The pressure is chosen to be great enough to disconnect the connection of the polymer membrane film to the fluidic barrier element.

Abstract: A method for active hybridization in microarrays includes pumping an already prepared sample through a denaturing unit with a microarray and then through a reaction region which is spatially separate from the denaturing unit. The denatured reactive sample components are hybridized in the reaction region.

Abstract: A method for preparing a sample of biological materials containing target cells and accompanying cells for extracting nucleic acids of the target cells includes accumulating the target cells of the sample by separating the target cells or the accompanying cells from the sample. The method also includes digesting the target cells via chemical and/or physical lysis in order to produce a target cell lysate containing the nucleic acids of the target cells. The method furthermore includes purifying the nucleic acids from the target cell lysate in order to extract the nucleic acids of the target cells.

Abstract: A microsystem for fluidic applications includes a substrate with a reservoir, a first microchannel, connected to the reservoir, and a second microchannel, separated from the first microchannel by a fixed member. The microsystem furthermore has an elastic film on the substrate, which film has a joint to the substrate around the reservoir and seals the reservoir. Here, the joint has a permanent joining area and, on the fixed member, a fixed member joining area that can be broken open and adjoins the permanent joining area at both ends of the fixed member. Such a microsystem forms a processing chip with reagent receptacle.

Abstract: A microfluidic device includes a first supply channel and a first discharge channel fluidically connected to one another by a first valve. The device also includes a second supply channel and a second discharge channel fluidically connected to one another by a second valve. At least one of the first channels can be fluidically connected to at least one of the second channels by a T-valve. The device also includes a control unit for controlling the valves, the control unit being configured in such a way that a first fluid from one of the first channels and a second fluid in one of the second channels can be laminated in parallel by actuating the valves in one of the first or second channels. A microfluidic system and a method for transporting fluids, and a use thereof are also disclosed.

Abstract: A film bag for storing a fluid, in particular a reagent or an auxiliary agent for a biochemical analysis method, includes a film, a seam, and an irreversibly destructible predetermined breaking point. The film is impermeable to the fluid and constituents of the fluid. The seam is formed in a fluid-tight manner between a first sub-region of the film and a second sub-region of the film and forms the film into a fluid-tight bag for accommodating the fluid. The bag is configured to be arranged in a chamber of a device that provides a fluid for a biochemical evaluating unit. The predetermined breaking point is formed from the film and is fluid-tight when a fluid pressure in the film bag is below a limit. The predetermined breaking point is destroyed when the fluid pressure is above the limit.

Abstract: A duct and a method for damping pressure waves caused by thermoacoustic instability, the duct comprising: a locking Helmholtz resonator positioned on the circumference of the duct, the locking Helmholtz resonator tuned to a first frequency; and one or more damping Helmholtz resonators positioned on the circumference of the duct at or adjacent to 90 and/or 270 degrees from the locking Helmholtz resonator, wherein the damping Helmholtz resonators are tuned to a second frequency which is different from the first frequency of the locking Helmholtz resonator.

Abstract: The present invention relates to a pressure-measuring device for measuring dynamic pressures in the high-temperature range, with a pressure line connected to a volume subjected to pressure and with a pressure sensor which is arranged at a distance from the inlet area of the pressure line to the volume, wherein the pressure line is provided with at least one pinhole diaphragm and connected to an additional damping volume, as well as to the use of the pressure-measuring device in a combustion chamber of a gas turbine.

Abstract: A microfluidic system for purposes of analysis and diagnosis is made up of layers arranged substantially one above the other. The microfluidic system includes at least a first and a second conducting-through layer, which respectively comprise at least one channel for a fluid to be conducted through in the respective conducting-through layer. The microfluidic system further includes at least one chip layer, which comprises at least one active, micromechanical element, the active, micromechanical element being in operative connection with at least one of the channels, and the chip layer being arranged between the first and the second conducting-through layer, and the channels being fluidically connected to one another. A corresponding production method is disclosed in addition to the microfluid system.

Abstract: A microfluidic cell for the dielectrophoretic separation, accumulation, and/or lysis of polarizable bioparticles, including an interdigital electrode system composed of two electrode groups having interdigitated electrodes, and a micromixer having microchannels and microelevations. The interdigital electrode system and the micromixer are situated on the same side of the cell to improve the separation, accumulation, and/or lysis characteristics. Moreover, also described is a microfluidic system which includes such a microfluidic cell, and use thereof, and a method for separating, accumulating, and/or lysing polarizable bioparticles.

Abstract: A duct and a method for damping pressure waves caused b thermoacoustic instability, the duct comprising: a locking Helmholtz resonator positioned on the circumference of the duct, the locking Helmholtz resonator tuned to a first frequency, and one or more damping Helmholtz resonators positioned on the circumference of the duct at or adjacent to 90 and/or 270 degrees from the locking Helmholtz resonator, wherein the damping Helmholtz resonators are tuned to a second frequency which is different from the first frequency of the locking Helmholtz resonator.

Abstract: A pinch valve, a chip including the pinch valve, a peristaltic pump including the pinch valve and a method for manufacturing the pinch valve. The pinch valve includes a first substrate, a second substrate, and a third substrate. The third substrate is formed from an elastic material and situated between the first and second substrates. The first substrate adjoins the third substrate and includes at least one first recess on the side adjacent to the third substrate. The second substrate adjoins the third substrate and includes at least one second recess on the side adjacent to the third substrate. The first recess and the second recess are situated at least partially opposite each other.

Abstract: A normally closed valve for microfluidic components includes a polymer substrate and a polymer membrane film arranged on the polymer substrate. The polymer substrate has a first chamber, a second chamber, and a fluidic barrier element configured to separate the first chamber from the second chamber. The first chamber is fluidically coupled to the second chamber by the polymer membrane film, and, in an initial configuration, a connection of the polymer membrane film to the fluidic barrier element prevents a fluidic communication of the first chamber to the second chamber. The first chamber is at least partially filled with a substance in the initial configuration, and a transfer of the substance from the first chamber into the second chamber takes place by applying a pressure to the substance. The pressure is chosen to be great enough to disconnect the connection of the polymer membrane film to the fluidic barrier element.

Abstract: A method for producing a multilayer system with at least two joining elements, these being produced in particular from plastic, is disclosed. The method includes applying a compensating means, for at least partially compensating for mechanical stresses, to a first joining element, applying a second joining element to the compensating means, for joining together the first and second joining elements, firstly connecting the first joining element to the compensating means and secondly connecting the second joining element to the compensating means. A corresponding multilayer system and a corresponding use is also disclosed.

Abstract: A device configured for lysing a sample includes a holding element configured to hold an energy-transmitting element such that the holding element lies around the held part of the energy-transmitting element and envelops the held part of the energy-transmitting element and/or that the holding element lies against the held part of the energy-transmitting element. The holding element is further configured to cause lysis with the energy-transmitting element when the holding element is immersed into the sample to be subjected to lysis or comes into contact with the sample to be subjected to lysis. A method includes inserting the energy-transmitting element into the holding element. A system configured for lysing a sample by way of ultrasound includes the device and the energy transmitting element.

Abstract: A device and a method for optical parallel analysis of a sample arrangement. The device includes a system of sample areas provided on and/or in a front face of the carrier substrate for receiving a sample substance; a system of detector areas provided on and/or in a back face of the carrier substrate, each detector area being assigned to a corresponding sample area; and a system of optical devices, each optical system being assigned to a corresponding sample area and being designed in such a way that it deflects light beams, which the corresponding sample area in response to an optical excitation does not emit in the direction of a detector area assigned to it, in the direction of the detector area assigned to it and/or in the direction of a detector-free area on the back face of the carrier substrate.

Abstract: A method for producing a microfluidic system, containing at least one microfluidic component having at least one microfluidically active surface is disclosed. The method includes providing a microfluidic composite substrate having a connection side, comprising at least one microfluidic component introduced into a polymer composition, wherein the microfluidically active surface of said component forms a part of the connection side of the microfluidic composite substrate. The method further includes providing a mating substrate having a connection side for connection to the microfluidic composite substrate. Also, the method includes providing microfluidic structures at least on the connection side of the composite substrate and/or on the connection side of the mating substrate at least for the purpose of forming a microfluidic channel structure in the microfluidic system.

Abstract: A method for active hybridization in microarrays includes pumping an already prepared sample through a denaturing unit with a microarray and then through a reaction region which is spatially separate from the denaturing unit. The denatured reactive sample components are hybridized in the reaction region.

Abstract: A microarray comprises a carrier substrate and a plurality of immobilization particles configured to immobilize capture molecules. Each immobilization particle comprises a first sub-section bonded to the carrier substrate and a second sub-section which is exposed.

Abstract: A combustion chamber head of a gas turbine has a substantially annular combustion chamber outer wall 18 as well as a substantially annular combustion chamber inner wall 42 and several burners 6 distributed around the circumference. The combustion chamber head 5 has an inflow-side wall 13 which together with a wall 14 facing the combustion chamber 7 forms a combustion chamber head volume 15. The inflow-side wall 13 is provided with at least one inflow opening 32, the wall 14 facing the combustion chamber 7 is provided with at least one outflow opening 17 for connecting the combustion chamber head volume 15 to the combustion chamber 7, and at least one cooling air duct 29 is provided in the wall 14 facing the combustion chamber 7. A method for cooling and damping of the combustion chamber head is also disclosed.