Patents by Inventor Jodi Michelle Kennedy

Jodi Michelle Kennedy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4?) gene expression
    Patent number: 11987791
    Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4?) gene by targeting an HNF4? expression control region and methods of use thereof for treating an HNF4? associated disorder, e.g., cirrhosis.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: May 21, 2024
    Assignee: Omega Therapeutics, Inc.
    Inventors: Jesse Jerome Smith, Jodi Michelle Kennedy, Jeremiah D. Farelli, Kendrick Alan Goss, Adam Walter Scheidegger, Yoseph Kassa, Christian Wessel Cobaugh, Timsi Rao
  • COMPOSITIONS AND METHODS FOR MODULATING MYC EXPRESSION
    Publication number: 20240132559
    Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 25, 2024
    Inventors: Abigail Elizabeth WITT, Jeremiah Dale FARELLI, Adam Walter SCHEIDEGGER, William Thomas SENAPEDIS, Jr., Jodi Michelle KENNEDY, Houda BELAGHZAL, Defne YARAR, Eugine LEE
  • COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION
    Publication number: 20230399640
    Abstract: The present disclosure relates to expression repressors and expression repression systems for modulating expression of a target gene in a cell.
    Type: Application
    Filed: September 24, 2021
    Publication date: December 14, 2023
    Inventors: Jodi Michelle KENNEDY, Jeremiah Dale FARELLI
  • COMPOSITIONS AND METHODS FOR INHIBITING THE EXPRESSION OF MULTIPLE GENES
    Publication number: 20230374549
    Abstract: The present disclosure relates to site-specific disrupting agents for modulating, e.g., decreasing, expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises pro-inflammatory genes, e.g., CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the method comprises using a first site-specific disrupting agent that targets a first anchor sequence and a second site-specific disrupting agents that disrupts a second anchor sequence.
    Type: Application
    Filed: September 29, 2021
    Publication date: November 23, 2023
    Inventors: Lauren Marie BEECH, Jesse Jerome SMITH, Rahul KARNIK, Kendrick Alan GOSS, Adam Walter SCHEIDEGGER, Jodi Michelle KENNEDY, Jeremiah Dale FARELLI, Houda BELAGHZAL, Laura Anh NGUYEN, Charles W. O'DONNELL
  • MODULATING GENOMIC COMPLEXES
    Publication number: 20220403387
    Abstract: The present disclosure relates generally to modulation of genomic complexes via modulation of non-genomic components such as, non-coding RNAs.
    Type: Application
    Filed: September 22, 2020
    Publication date: December 22, 2022
    Inventors: Laura Gabriela Lande, David Arthur Berry, Jodi Michelle Kennedy, Jeremiah Dale Farelli
  • COMPOSITIONS AND METHODS FOR MODULATING HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (HNF4alpha) GENE EXPRESSION
    Publication number: 20220348908
    Abstract: The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4a) gene by targeting an HNF4? expression control region and methods of use thereof for treating an HNF4? associated disorder, e.g., cirrhosis.
    Type: Application
    Filed: September 23, 2020
    Publication date: November 3, 2022
    Inventors: Jesse Jerome Smith, Jodi Michelle Kennedy, Jeremiah D. Farelli, Kendrick Alan Goss, Adam Walter Scheidegger, Yoseph Kassa, Christian Wessel Cobaugh, Timsi Rao
  • METHODS AND COMPOSITIONS FOR MODULATING FRATAXIN EXPRESSION AND TREATING FRIEDRICH'S ATAXIA
    Publication number: 20220348893
    Abstract: The present disclosure relates generally to methods and compositions for modulating frataxin (FXN) expression, e.g., to treat Friedreich ataxia (FRDA).
    Type: Application
    Filed: September 23, 2020
    Publication date: November 3, 2022
    Inventors: Serena Lunardi, Adam Walter Scheidegger, Jesse Jerome Smith, Jeremiah Dale Farelli, Jodi Michelle Kennedy