Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A nut and washer assembly includes a washer unit that is coupled to a nut. The washer unit includes a housing and a washer that is disposed within a sleeve on an inner surface of the housing such that the washer is inseparable from and axially rotatable with respect to the housing. The housing is attached to the nut such that the washer captured within the housing of the washer unit and the nut operate as a single unit.

Abstract: A nut and washer assembly includes a washer unit that is coupled to a nut. The washer unit includes a housing and a washer that is disposed within a sleeve on an inner surface of the housing such that the washer is inseparable from and axially rotatable with respect to the housing. The housing is attached to the nut such that the washer captured within the housing of the washer unit and the nut operate as a single unit.

Abstract: A nut and washer assembly includes a washer unit that is coupled to a nut. The washer unit includes a housing and a washer that is disposed within a sleeve on an inner surface of the housing such that the washer is inseparable from and axially rotatable with respect to the housing. The housing is attached to the nut such that the washer captured within the housing of the washer unit and the nut operate as a single unit.

Abstract: A computer implemented method and system for managing financial data (FD) in real time provides a financial management platform (FMP) that aggregates and categorizes FD from financial user accounts and generates an N-dimensional financial format (NDFF) to store and render the aggregated and categorized FD in a transformed and modifiably categorized configuration on a graphical user interface (GUI). The FMP computes current metrics using the aggregated and categorized FD. The FMP dynamically adapts the current metrics to reflect changes caused by user interactions with interactive components and visualizations of the rendered FD in the NDFF on the GUI. The FMP generates dynamic real-time financial projections based on the computed and adapted current metrics and configurable parameters.