Patents by Inventor Joe De Angelo

Joe De Angelo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast synthetic biology platform for identifying shikimate pathway enzyme inhibitors
    Patent number: 10865417
    Abstract: Provided are compositions and methods for compound discovery. Modified yeast that have their endogenous yeast shikimate pathway disrupted or deleted, and replaced with homologous pathway genes from one or more distinct organisms, are provided and used in assays of test agents. The homologous pathway genes are designed to supplement the disrupted or deleted shikimate pathway genes. The assays are designed to identify whether or not the test agents can interfere with the function of enzymes in the shikimate pathway from organisms that are distinct from the yeast avatar hosts. In embodiments, the disruption/deletion of the yeast endogenous shikimate pathway results in the yeast being incapable of producing chorismic acid.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: December 15, 2020
    Assignees: New York University, Neochromosome Inc., The Johns Hopkins University
    Inventors: Jef Boeke, Leslie Mitchell, Joe De Angelo, Joel S. Bader
  • YEAST SYNTHETIC BIOLOGY PLATFORM FOR IDENTIFYING SHIKIMATE PATHWAY ENZYME INHIBITORS
    Publication number: 20190309314
    Abstract: Provided are compositions and methods for compound discovery. Modified yeast that have their endogenous yeast shikimate pathway disrupted or deleted, and replaced with homologous pathway genes from one or more distinct organisms, are provided and used in assays of test agents. The homologous pathway genes are designed to supplement the disrupted or deleted shikimate pathway genes. The assays are designed to identify whether or not the test agents can interfere with the function of enzymes in the shikimate pathway from organisms that are distinct from the yeast avatar hosts. In embodiments, the disruption/deletion of the yeast endogenous shikimate pathway results in the yeast being incapable of producing chorismic acid.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 10, 2019
    Inventors: Jef Boeke, Leslie Mitchell, Joe De Angelo, Joel S. Bader