Abstract: A work set up method and apparatus is disclosed for use with tape controlled machine tools including quick connect ball locks which accurately lock one or more fixtures and workpieces to a work table. The tape is indexed with one ball lock and controls the machining of the workpiece. The fixture and workpiece may be locked to the table of other tape controlled machines for performing other machining functions on the workpiece. A second embodiment includes a work set up apparatus in combination with a drill holding mechanism and at least one multiple spindle drilling head secured to the vertically movable head of a multiple drilling head machine. Depending upon the complexity and size of the workpiece and the number of drills in the second embodiments, set up time is reduced from a prior art time of between about 4-16 hours to between about 5-20 minutes in accordance with the present invention.