Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: An improved signal line routing scheme includes a plurality of dynamic signal lines disposed in parallel to each other, and a plurality of static signal lines disposed in parallel to each other and also disposed in parallel with the plurality of dynamic signal lines, wherein at least one of the plurality of static signal lines is disposed immediately adjacent to each one of the plurality of dynamic signal lines.