Abstract: A clinical trial operations system includes: patient, clinician, and coordinator applications; a patient sensor that provides health measurements through the patient application; a clinical sensor that provides in-office health measurements through the clinician application; and a trial operations service suite that receives and analyzes data from the patient application, the clinician application, and the coordinator application and provides data to the patient application, the clinician application, and the coordinator application via a set of portals including a patient portal, a clinician portal, and a coordinator portal, where the coordinator application and the coordinator portal allow a coordinator user to develop, build, customize, and establish trial protocol and participant interaction.

Abstract: A trial operations service suite in a clinical trial operations system includes: patient, clinician, investigator, and coordinator portals supporting corresponding applications and providing specific services for each type of participant, where the coordinator portal allows a coordinator user to develop, build, customize, and establish trial protocol and participant interaction using an application factory system embedded within a trial design aspect of the coordinator portal; security configuration and management authentication databases; operational databases including trial data including provisioning and authorization data describing trial participants, access logs recording participant activity, protected and de-identified health information and/or non-health provided by patients, clinicians, and associated sensors; a notification relay service and corresponding external notifications gateway providing essential communication between the system and users, between clinicians and patients, and between coor

Abstract: A method of recovering a registry includes accessing a plurality of registry zone files for the registry and archiving, on a first periodic basis, the plurality of registry zone files. Each of the registry zone files includes at least domain names, registrar IDs, and status information represented in a first predetermined format. The method also includes accessing bulk WHOIS data for the registry and archiving, on a second periodic basis, the bulk WHOIS data. The bulk WHOIS data includes at least nameserver server names, IP addresses, and status information represented in a second predetermined format. The method further includes validating one of the plurality of archived registry zone files based on a comparison between the plurality of registry zone files and the bulk WHOIS data, publishing the validated registry zone file to a second registry's nameservers, initiating a root zone change request, and updating authoritative nameservers.

Abstract: A system and method for establishing a chain of trust from a registrant to a registry. A registrant request to a registrar to change a domain name record includes at least one registrant factor, such as a one time password. The registrar can formulate an extended EPP command that includes the factor to effectuate the change and send it to a registry. The registry can verify the at least one factor using at least one validation server. If the factor is successfully verified, the EPP can be processed by the registry. If the factor is not verified, the EPP command may not be processed and an error message may be generated and sent to the registrar.

Abstract: A method of recovering a registry includes accessing a plurality of registry zone files for the registry and archiving, on a first periodic basis, the plurality of registry zone files. Each of the registry zone files includes at least domain names, registrar IDs, and status information represented in a first predetermined format. The method also includes accessing bulk WHOIS data for the registry and archiving, on a second periodic basis, the bulk WHOIS data. The bulk WHOIS data includes at least nameserver server names, IP addresses, and status information represented in a second predetermined format. The method further includes validating one of the plurality of archived registry zone files based on a comparison between the plurality of registry zone files and the bulk WHOIS data, publishing the validated registry zone file to a second registry's nameservers, initiating a root zone change request, and updating authoritative nameservers.

Abstract: A system and method for establishing a chain of trust from a registrant to a registry. A registrant request to a registrar to change a domain name record includes at least one registrant factor, such as a one time password. The registrar can formulate an extended EPP command that includes the factor to effectuate the change and send it to a registry. The registry can verify the at least one factor using at least one validation server. If the factor is successfully verified, the EPP can be processed by the registry. If the factor is not verified, the EPP command may not be processed and an error message may be generated and sent to the registrar.