Abstract: Disclosed are methods of treating cancers by inhalation of stable platinum-containing formulations.

Abstract: An inhalation system comprising an antiinfective agent in particle form, the antiinfective agent being directed toward prevention and treatment of intracellular infection, and an inhalation device, and a method of use of the system.

Abstract: A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film by entering the film via the smaller pores and extruded via the larger pores, under pressure, is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a predetermined maximum size. Also disclosed is an apparatus for carrying out the invention.

Abstract: Disclosed are methods of treating cancers by inhalation of stable platinum-containing formulations.

Abstract: A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film under pressure is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a predetermined maximum size. Also disclosed is an apparatus for carrying out the invention.

Abstract: A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has an enclosed, sterilizable, gripable housing and can be used to mix combine fluids in reproducible and predetermined proportions. Combination is accomplished aseptically, avoiding contact between the device's operator and the fluids and the substances combined. Biologically active compounds can be combined with one or more fluids, including such aqueous liposome suspensions, using the device. A formulation preparation kit containing, in addition to the device, the fluids and compounds to be formulated is thus also provided herein; methods of using the device to prepare such formulations are further provided herein.

Abstract: A pharmaceutical dosage form comprising gelatin encapsulating a pharmaceutical composition wherein said composition is at least about 6% (weight %) ethanol and lipid wherein said lipid comprises at least about 60% (weight %) and a method of protecting gelatin from deterioration is disclosed.

Abstract: The application discloses a combination medicament container and transfer device connected with a bellows type sleeve. The transfer device is a double ended spike having internal conduits optionally vented through a sterile hydropholic allowing two way transfer of liquid from an intravenous solution container and a medicament container of relatively insoluble medicament.

Abstract: A unit dose applicator for liquid ophthalmic medicaments in solution or suspension has an elongated housing for the medicament; at one end of the housing there is an opening for at least partially emptying the contents of the housing; at the other end of the housing is a second opening; and the second opening is capped by a diaphragm-like seal having a sufficient displacement potential to exude only 1 to 4 drops of the medicament.

Abstract: Improved anti-inflammatory suspensions for parenteral applications, comprising 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl acetic acid as active ingredient.

Abstract: Improved anti-inflammatory suspensions for ophthalmic applications, comprising 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl acetic acid as active ingredient.