Abstract: Disclosed are compounds and methods for preventing or treating necroinflammation associated with ferroptotic processes. The method includes inhibiting 15 lipoxygenase/phosphatidylethanolamine binding protein (15LOX/PEBP1) complex, wherein the inhibitor exhibits a higher binding affinity or binding activity for 15LOX/PEBP1 complex compared to 15LOX alone. Necroinflammation associated with ferroptotic processes causes several pathogenic conditions including upper or lower respiratory disorders, acute or chronic brain injury, renal injury, injury by radiation, neurodegenerative disorder, among others. The disclosed compounds and methods are useful in subjects diagnosed with one or more of these conditions.

Abstract: Disclosed herein are gastrointestinal tract (G1) bacteria and methods for treating or preventing an irradiation-induced intestinal damage in a subject, the methods comprising administering a G1 bacterium to the subject, wherein the G1 bacterium comprises a vector that comprises a polynucleotide encoding IL-22 and/or IFN-P, or a functional fragment thereof.

Abstract: Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.

Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Abstract: Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.

Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Abstract: A pipelined linear array of processor elements (PEs) for performing matrix computations in an efficient manner. The linear array generally includes a head PE and a set of regular PEs, the head PE being a functional superset of the regular PE, with interconnections between nearest neighbor PEs in the array and a feedback path from a non-neighbor regular PE back to the head PE. Each PE includes arithmetic circuitry for performing multiply, combine and accumulate operations, and a register file for storing inputs and outputs of the arithmetic circuitry. The head PE further includes a non-linear function generator. Each PE is pipelined such that the latency for an arithmetic operation to complete is a multiple of the period with which new operations can be initiated. A Very Large Instruction Word (VLIW) program or other type of program may be used to control the array. The array is particularly efficient at performing complex matrix operations, such as, e.g.

Abstract: A digital circuit for computing a function consisting of sums and differences of the products of a first vector of N multipliers and a second vector of M multiplicands, where at least one of N and M is greater than one include N multibit recoding circuits and M multiples generator circuits. Each recoding circuit receives a respective multiplier as input and produces a radix-2k signed digit representation of the multiplier as output. Each multiples generator receives a respective multiplicand as input and producing multiples of the multiplicand between one and 2k−1 as output. The output of N recoding circuits and M multiples generator circuits are fed to an N×M array of partial product summers. Each partial product summer produces a respective product output, the set of outputs of the partial product summers comprising the product of each of the multipliers with each of the multiplicands.

Abstract: An application-specific single chip digital processor having flexible design expansion capability with minimal impact on the performance of a processor core. The processor core has an ALU and a register file (accumulators). The output of the ALU is connected to a multiplexer whose output is connected to the input of the register file. The output of the register file connects to one input of the ALU. A function unit, separate from the core, has an input connected to the output of the register file and an output connected to another input to the multiplexer. The core operates with a predefined instruction set. The function unit, which may be redesigned depending on the application, operates with a reserved (uncommitted) instruction set under control of the core.

Abstract: A patient is automatically accurately positioned relative to a fixed refece of a treatment/diagnostic device by an optical system which operates a patient positioning assembly to bring fiducials or skin markers on the patient into coincidence with impingement points of laser beams projected in a fixed pattern relative to the device. Cameras record images of the fiducials and laser impingement points from which alignment error and velocity error in pixel space are determined. The velocity error in pixel space is converted to a velocity error in room space by the inverse of an Image Jacobian. The Image Jacobian is initially derived using rough values for system parameters and is continuously updated and refined using the calculated errors in pixel space derived from the camera images and errors in room space derived from position encoders on the treatment/diagnostic device.

Abstract: There is disclosed an integrated circuit including a digital processor having EEPROM and a control register. The digital processor is capable of receiving data to be programmed into the EEPROM and is capable of programming the data into the EEPROM. The digital processor includes a control register for receiving bits to control a write line and an erase line. The digital processor also includes a processor core coupled to the control register by a data bus, the digital processor is coupled to the EEPROM by a ROM address bus and a RAM data bus. The EEPROM memory location identified by the ROM address bus is programmed to retain data latched onto the RAM data bus. This is achieved by the digital processor writing control bits to the control register to enable the write line for a write operation of sufficient duration to assure that the data on the RAM data bus is retained in the EEPROM memory address that is enabled.

Abstract: An application-specific single chip digital processor having flexible design expansion capability with minimal impact on the performance of a processor core. The processor core has an ALU and a register file (accumulators). The output of the ALU is connected to a multiplexer whose output is connected to the input of the register file. The output of the register file connects to one input of the ALU. A function unit, separate from the core, has an input connected to the output of the register file and an output connected to another input to the multiplexer. The core operates with a predefined instruction set. The function unit, which may be redesigned depending on the application, operates with a reserved (uncommitted) instruction set under control of the core.

Abstract: An integrated circuit including a circuit for improved efficiency of internal data transfer comprises: a processor core having a buffer memory; a random access memory having a read and write cycle time of a one clock cycle, the random access memory comprising a memory array with a predetermined word width and a data latch coupled to the memory array; a bi-directional data bus coupling the processor core to the random access memory, the bi-directional data bus having a data width which is a multiple of at least one times the predetermined word width; and, a signal circuit coupled to the data latch wherein the data latch is responsive to the signal circuit to latch data from the bi-directional data bus prior to writing the data to the memory array, wherein alternately reading two consecutive data words and writing two consecutive words occurs on an average in the clock cycle.

Abstract: X-ray images such as radiotherapy portal images and simulation images are matched by apparatus which digitizes the images and automatically processes the digitized signals to generate matched digitized signals which can be displayed for comparison. The digitized images are first coarse aligned using a transform generated from seed points selected interactively from the two images or through detection and identification of x-ray opaque fiducials placed on the patient. A fine alignment is then performed by first selecting intersecting regions of the two images and enhancing those regions. Secondly, an updated transform is generated using robust motion flow in these regions at successive ascending levels of resolution. The updated transform is then used to align the images which are displayed for comparison. The updated transform can also be used to control the radiotherapy equipment.

Abstract: A camera generates digital image signals representing an image of one or more natural or artificial fiducials on a patient positioned on treatment or diagnosis equipment. A processor applies multiple levels of filtering at multiple levels of resolution to repetitively determine successive fiducial positions. A warning signal is generated if movement exceeds certain limits but is still acceptable for treatment. Unacceptable displacement results in termination of the treatment beam. Tracking templates can be generated interactively from a display of the digital image signals or through automatic selection of an image having the median correlation to an initial template. A gating signal synchronized to patient breathing can be extracted from the digital image signals for controlling the radiation beam generator.