Patents by Inventor Joel K. Weltman

Joel K. Weltman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of expression of interleukin-5
    Patent number: 6048726
    Abstract: A method of inhibiting interleukin-5 expression using an antisense oligonucleotide which contains at least one non-natural internucleoside linkage.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: April 11, 2000
    Inventors: Joel K. Weltman, Aftab S. Karim
  • Screening antibodies for capacity to deliver toxin to target cells
    Patent number: 4689311
    Abstract: Treatment and screening materials and methods (as for cancer) are provided in which there is provided between a toxin and an anticancer antibody an intermediate antibody with an affinity for either the toxin or the anticancer antibody.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: August 25, 1987
    Assignee: Rhode Island Hospital
    Inventor: Joel K. Weltman
  • Process for the detection of antibodies
    Patent number: 4360592
    Abstract: Novel enzyme conjugates useful in immunoassay methods are prepared with the use of a novel coupling reagent of N-succinimidyl (4-iodoacetyl) aminobenzoate by reacting the coupling reagent, firstly, with an amino-containing macromolecule, and, thereafter, with a sulfhydryl-containing enzyme, the enzyme conjugate prepared in a high yield and of high specificity.
    Type: Grant
    Filed: November 10, 1980
    Date of Patent: November 23, 1982
    Inventor: Joel K. Weltman
  • N-succinimidyl haloacetyl aminobenzoates as coupling agents
    Patent number: 4251445
    Abstract: Novel enzyme conjugates useful in immunoassay methods are prepared with the use of a novel coupling reagent of N-succinimidyl (4-iodoacetyl) aminobenzoate by reacting the coupling reagent, firstly, with an amino-containing macromolecule, and, thereafter, with a sulfhydryl-containing enzyme, the enzyme conjugate prepared in a high yield and of high specificity.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: February 17, 1981
    Inventor: Joel K. Weltman
  • Enzyme conjugates and method of preparation and use
    Patent number: 4218539
    Abstract: Novel enzyme conjugates useful in immunoassay methods are prepared with the use of a novel coupling reagent of N-succinimidyl (4-iodoacetyl) aminobenzoate by reacting the coupling reagent, firstly, with an amino-containing macromolecule, and, thereafter, with a sulfhydryl-containing enzyme, the enzyme conjugate prepared in a high yield and of high specificity.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: August 19, 1980
    Inventor: Joel K. Weltman
  • Enzyme conjugates
    Patent number: 4002532
    Abstract: This invention relates to the provision of enzyme-macromolecule conjugates by conjugation with polyfunctional reagents in the presence of organic compounds which act as conditioners. Conjugation of enzymes with antibodies in the presence of conditioner yields conjugates with increased immunological specificity. Organic polyamines of either high or low molecular weight are conditioners. Conditioners are especially useful for conjugation of polymeric and unstable enzymes such as .beta.-D-galactosidase. The high degree of immunospecificity and sensitivity achieved with conditioners yields conjugates suitable for detection and quantification of substances, such as IgE, in nanogram quantities in biological fluids with many interfering substances.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: January 11, 1977
    Inventors: Joel K. Weltman, M. Boris Rotman