Patents by Inventor Joel M. Friedman
Joel M. Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11532087Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: GrantFiled: January 22, 2021Date of Patent: December 20, 2022Assignee: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman
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Patent number: 11484493Abstract: A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.Type: GrantFiled: December 30, 2021Date of Patent: November 1, 2022Assignee: Albert Einstein College of MedicineInventor: Joel M. Friedman
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Publication number: 20220280259Abstract: Aspects of the disclosure relate to the identification of when a blood vessel has been sufficiently cleared of blood so as to capture intravascular images of the vessel wall. The disclosed systems and methods allow for the identification of an initial and a final blood clearing based on the identification of edges within scanlines of a plurality of image frames. The edges of a plurality of scanlines may be analyzed to determine an average edge offset for each image frame, and the average edge offsets for a plurality of image frames may be averaged over various time-windows, so as to determine when the initial and final blood clearing events have occurred. Once a final blood clearing event has been identified, the disclosed system may automatically initiate a catheter pullback procedure, so as to capture intravascular images over a length of the vessel that has been sufficiently cleared of blood.Type: ApplicationFiled: March 2, 2022Publication date: September 8, 2022Applicant: LightLab Imaging, Inc.Inventors: Christopher E. Griffin, Joel M. Friedman, Ashley Netravali, Lingfa Yang
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Patent number: 11435233Abstract: In part, the invention relates to systems and methods of calibrating a plurality of frames generated with respect to a blood vessel as a result of a pullback of an intravascular imaging probe being pullback through the vessel. A calibration feature disposed in the frames that changes between a subset of the frames can be used to perform calibration. Calibration can be performed post-pullback. Various filters and image processing techniques can be used to identify one or more feature in the frames including, without limitation, a calibration feature, a guidewire, a side branch, a stent strut, a lumen of the blood vessel, and other features. The feature can be displayed using a graphic user interface.Type: GrantFiled: January 15, 2020Date of Patent: September 6, 2022Assignee: LightLab Imaging, Inc.Inventors: Joel M. Friedman, Amr Elbasiony
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Publication number: 20220142913Abstract: A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.Type: ApplicationFiled: January 26, 2022Publication date: May 12, 2022Applicant: Albert Einstein College of MedicineInventor: Joel M. Friedman
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Publication number: 20220142947Abstract: A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions by enhancing systemic level of nitric oxide.Type: ApplicationFiled: December 30, 2021Publication date: May 12, 2022Applicant: Albert Einstein College of MedicineInventor: Joel M. Friedman
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Publication number: 20220095933Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 21, 2021Publication date: March 31, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20220095934Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 22, 2021Publication date: March 31, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20220095932Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 21, 2021Publication date: March 31, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20220087544Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 21, 2021Publication date: March 24, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20220039667Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 22, 2021Publication date: February 10, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20220039668Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 22, 2021Publication date: February 10, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20210217175Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: ApplicationFiled: January 22, 2021Publication date: July 15, 2021Applicant: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman
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Patent number: 10902599Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: GrantFiled: October 22, 2018Date of Patent: January 26, 2021Assignee: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman
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Publication number: 20200355557Abstract: In part, the invention relates to systems and methods of calibrating a plurality of frames generated with respect to a blood vessel as a result of a pullback of an intravascular imaging probe being pullback through the vessel. A calibration feature disposed in the frames that changes between a subset of the frames can be used to perform calibration. Calibration can be performed post-pullback. Various filters and image processing techniques can be used to identify one or more feature in the frames including, without limitation, a calibration feature, a guidewire, a side branch, a stent strut, a lumen of the blood vessel, and other features. The feature can be displayed using a graphic user interface.Type: ApplicationFiled: January 15, 2020Publication date: November 12, 2020Applicant: LightLab Imaging, Inc.Inventors: Joel M. Friedman, Amr Elbasiony
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Patent number: 10551251Abstract: In part, the invention relates to systems and methods of calibrating a plurality of frames generated with respect to a blood vessel as a result of a pullback of an intravascular imaging probe being pullback through the vessel. A calibration feature disposed in the frames that changes between a subset of the frames can be used to perform calibration. Calibration can be performed post-pullback. Various filters and image processing techniques can be used to identify one or more feature in the frames including, without limitation, a calibration feature, a guidewire, a side branch, a stent strut, a lumen of the blood vessel, and other features. The feature can be displayed using a graphic user interface.Type: GrantFiled: May 30, 2017Date of Patent: February 4, 2020Assignee: LIGHTLAB IMAGING, INC.Inventors: Joel M. Friedman, Amr Elbasiony
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Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods
Publication number: 20190380594Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: August 23, 2019Publication date: December 19, 2019Applicant: LIGHTLAB IMAGING, INC.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony -
Publication number: 20190220980Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: ApplicationFiled: October 22, 2018Publication date: July 18, 2019Applicant: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman
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Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods
Publication number: 20180344174Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimate blood flow rate, a number of clinically significant physiological parameters are then determine and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: March 12, 2013Publication date: December 6, 2018Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony -
Patent number: 10109058Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: GrantFiled: May 17, 2016Date of Patent: October 23, 2018Assignee: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman