Patents by Inventor Joel M. Kauffman
Joel M. Kauffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080064880Abstract: Compounds that absorb ultraviolet light 380 nm to 400 nm range but avoid absorption in the blue light range, thereby imparting yellowness, i.e., 410-420 nm have suitable refractive characteristics useful in the preparation of optical resins or plastics suitable, for example, for the manufacture of ophthalmic lenses. Methods for making the compounds, optic lenses containing the compounds, and methods for making these are also described.Type: ApplicationFiled: December 30, 2005Publication date: March 13, 2008Applicant: Essilor International Compagnie Generale d' OptiqueInventors: Joel M. Kauffman, Peter T. Litak, Martin Rickwood
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Patent number: 6624153Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: wherein X1 is a halogen and X2 is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: wherein X1 is a halogen and X2 is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.Type: GrantFiled: September 9, 2002Date of Patent: September 23, 2003Assignee: University of Sciences in PhiladelphiaInventors: Farzad Kobarfard, Joel M. Kauffman
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Publication number: 20030114531Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized.Type: ApplicationFiled: September 9, 2002Publication date: June 19, 2003Inventors: Farzad Kobarfard, Joel M. Kauffman
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Publication number: 20020173548Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized.Type: ApplicationFiled: March 9, 2001Publication date: November 21, 2002Inventors: Farzad Kobarfard, Joel M. Kauffman
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Patent number: 6482982Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: wherein X1 is a halogen and X2 is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: wherein X1 is a halogen and X2 is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.Type: GrantFiled: March 8, 2001Date of Patent: November 19, 2002Assignee: University of Sciences of PhiladelphiaInventors: Farzad Kobarfard, Joel M. Kauffman
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Patent number: 5587112Abstract: A new class of proton transfer, benzazole, fluorescent compounds is composed of a 2-benzazolyl moiety covalently bonded to an aromatic fused ring heterocyclic moiety. The 2-benzazolyl moiety may be a 2-benzoxazolyl, 2-benzothiazolyl, or 2-benzimidazolyl. The aromatic fused ring heterocyclic moiety may be a 3-dibenzofuranyl or 3-dibenzothiophenyl each substituted at the 2 position with a proton donating group, or a 2-carbazolyl substituted at the 3 position with a proton donating group. The proton donating group may be hydroxy, sulfonamido, carbonamido, and the like, and preferably is hydroxy. The fluors are soluble in organic matrix materials such as solvents, monomers, resins, polymers, and the like. The UV-excited fluors emit short-lived fluorescence at .gtoreq.520 nm and may be used in the manufacture of fluorescent coatings, objects, scintillators, light sources and the like.Type: GrantFiled: September 2, 1994Date of Patent: December 24, 1996Assignee: Philadelphia College of Pharmacy and ScienceInventors: Joel M. Kauffman, Peter T. Litak
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Patent number: 5298189Abstract: A novel class of proton transfer, bis-benzazole, fluorescent compounds, i.e., fluors, is disclosed. The novel fluors include substituted or unsubstituted 1,4-bis(2-benzazolyl)-2-hydroxybenzenes and 1,4-bis(2-benzazolyl)-2-amidobenzenes wherein the benzazolyl group may be benzoxazolyl, benzimidazolyl, benzothiazolyl, and the like. The benzazolyl groups may be substituted with one or more alkyl groups to improve solubility in organic matrix materials such as solvents, monomers, resins, polymers, and the like. The novel fluors may be used in the manufacture of fluorescent coatings, objects, scintillators, light sources and the like. The novel fluors are particularly useful for radiation-hard, solid scintillators for the detection and measurement of high energy particles and radiation.Type: GrantFiled: April 24, 1992Date of Patent: March 29, 1994Assignee: Nanoptics IncorporatedInventor: Joel M. Kauffman
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Patent number: 5041238Abstract: Disclosed are organic laser dyes and more particularly o,o'-bridged oligophenylene laser dyes which when excited to lase emit radiation in various ranges and especially in the ultraviolet and violet ranges, that is, from about 300 nm to about 420 nm, of the light spectrum. An organic laser dye of this invention comprises an oligophenylene having at least one biphenyl moiety bridged between adjacent ortho positions via a single atom or a plural of atom substituents of various sizes. In one most preferred embodiment, the substituent bonded to the phenyl moieties forming the bridge is a carbon atom free of benzylic hydrogens. The bridging substituent can also be other atoms or groups free of reactive substituents. In another most preferred embodiment, the o,o'-bridged oligophenylene laser dyes are free of vinylene groups bonded directly to the phenyl moieties forming the oligophenylene chains.Type: GrantFiled: August 22, 1988Date of Patent: August 20, 1991Assignee: Exciton Chemical CompanyInventors: Joel M. Kauffman, Charles J. Kelley, Richard N. Steppel
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Patent number: 5037578Abstract: Disclosed are organic laser dyes and more particularly o,o'-bridged oligophenylene laser dyes which when excited to lase emit radiation in various ranges and especially in the ultraviolet and violet ranges, that is, from about 300 nm to about 420 nm, of the light spectrum. An organic laser dye of this invention comprises an oligophenylene having at least one biphenyl moiety bridged between adjacent ortho positions via a single atom or a plural of atom substituents of various sizes. In one most preferred embodiment, the substituent bonded to the phenyl moieties forming the bridge is a carbon atom free of benzylic hydrogens. The bridging substituent can also be other atoms or groups free of reactive substituents. In another most preferred embodiment, the o,o'-bridged oligophenylene laser dyes are free of vinylene groups bonded directly to the phenyl moieties forming the oligophenylene chains.Type: GrantFiled: April 2, 1990Date of Patent: August 6, 1991Assignee: Exciton Chemical CompanyInventors: Joel M. Kauffman, Charles J. Kelley, Richard N. Steppel
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Patent number: 4663074Abstract: Laser dyes of the class of 2-substituted oxazolo [4,5-b] pyridines which lase when flashlamp or nitrogen laser pumped.Type: GrantFiled: April 3, 1985Date of Patent: May 5, 1987Assignee: The United States of America as represented by the Secretary of the NavyInventors: Aaron N. Fletcher, Joel M. Kauffman
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Patent number: 4124527Abstract: Liquid scintillation counting compositions which include certain polyethoxylated poly(oxypropylene) emulsifiers allow stable dispersion of aqueous or other samples merely by shaking. Preferred are mixtures of such emulsifiers, which give homogeneous, monophasic-appearing dispersions over wide ranges of temperature and aqueous sample content. Certain of these emulsifiers, without being mixed, are of particular advantage when used in analysis of samples obtained through radioimmunoassay techniques, which are extremely difficult to disperse. Certain of these emulsifiers, also without being mixed, uniformly give homogeneous, monophasic appearing aqueous counting samples over much wider ranges of aqueous sample content and temperature than prior sample emulsifiers.Type: GrantFiled: December 15, 1975Date of Patent: November 7, 1978Assignee: New England Nuclear CorporationInventor: Joel M. Kauffman
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Patent number: 3939094Abstract: Liquid scintillation counting compositions which include certain polyethoxylated poly(oxypropylene) emulsifiers allow stable dispersion of aqueous or other samples merely by shaking. Preferred are mixtures of such emulsifiers, which give homogeneous, monophasic-appearing dispersions over wide ranges of temperature and aqueous sample content. Certain of these emulsifiers, without being mixed, are of particular advantage when used in analysis of samples obtained through radioimmunoassay techniques, which are extremely difficult to disperse. Certain of these emulsifiers, also without being mixed, uniformly give homogeneous, monophasic appearing aqueous counting samples over much wider ranges of aqueous sample content and temperature than prior sample emulsifiers.Type: GrantFiled: November 30, 1973Date of Patent: February 17, 1976Assignee: New England Nuclear CorporationInventor: Joel M. Kauffman