Patents by Inventor Joel R. Cherry
Joel R. Cherry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100105599Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.Type: ApplicationFiled: September 18, 2009Publication date: April 29, 2010Applicants: Novozymes A/S, Maxygen Inc.Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Jeremy S. Minshull
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Patent number: 7605115Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.Type: GrantFiled: April 17, 2007Date of Patent: October 20, 2009Assignees: Novozymas Als, Maxygen Inc.Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Jeremy Minshull
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Patent number: 7220566Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.Type: GrantFiled: December 15, 2003Date of Patent: May 22, 2007Assignees: Novozymes A/s, Maxygen, Inc.Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Jeremy Minshull
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Patent number: 6902922Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.Type: GrantFiled: April 2, 2001Date of Patent: June 7, 2005Assignees: Novozymes A/S, Maxygen, Inc.Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Willem P. C. Stemmer, Jeremy Minshull
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Publication number: 20040203130Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.Type: ApplicationFiled: December 15, 2003Publication date: October 14, 2004Applicants: Novozymes A/S, Maxygen Inc.Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Jeremy Minshull
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Publication number: 20030199038Abstract: The present invention relates to methods for preparing variants of a nucleotide sequence, comprising: (a) introducing into a population of filamentous fungal host cells: (i) one or more circular plasmids comprising a DNA sequence and a plasmid replicator mediating autonomous replication, wherein the one or more circularized plasmids are linearized by digestion of the DNA sequence and removal of a portion of the DNA sequence; and (ii) a library of DNA fragments comprising one or more mutations of the DNA sequence, wherein the fragments comprise at least two regions, one or more regions which are homologous to the 5′ region or the 3′ region of the gap in the linearized DNA sequence and/or plasmid sequence and one or more second regions which are homologous to the 5′ region or the 3′ region of the DNA fragments of the library; wherein the linearized plasmids and the DNA fragments recombine by in vivo recombination to produce a plurality of autonomously replicating plasmids comprising oneType: ApplicationFiled: April 22, 2003Publication date: October 23, 2003Applicant: Novozymes Biotech, Inc.Inventors: Howard Brody, Suzanne M. Otani, Joel R. Cherry
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Publication number: 20030049827Abstract: New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.Type: ApplicationFiled: April 2, 2001Publication date: March 13, 2003Inventors: Jon E. Ness, Mark Welch, Lorraine J. Giver, Joel R. Cherry, Torben V. Borchert, Willem P.C. Stemmer, Jeremy Minshull
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Patent number: 6368805Abstract: A method for the construction of a library of recombined polynucleotides from a number of different starting single or double stranded parental DNA templates is disclosed, wherein the starting single or double stranded parental DNA templates represent discrete points in a population of genes encoding evolutionary or synthetic homologues of a peptide having homologies ranging over a broad spectrum from less than 15% to more than 80%, said population exhibiting at least one identification sequence, and whereby said genes are subjected to a gene shuffling procedure to generate shuffled mutants of said population of genes representing additional discrete points between those of said starting templates.Type: GrantFiled: August 23, 2000Date of Patent: April 9, 2002Assignee: Novozymes A/SInventors: Torben Vedel Borchert, Titus Kretzschmar, Joel R. Cherry, Vind Jesper
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Patent number: 6306630Abstract: The present invention relates to Aspergillus porphobilinogen synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the porphobilinogen synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the porphobilinogen synthases.Type: GrantFiled: September 30, 1998Date of Patent: October 23, 2001Assignee: Novozymes Biotech, Inc.Inventors: Aubrey Jones, Joel R. Cherry
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Patent number: 6291165Abstract: The present invention relates to a new method of shuffling especially heterologous polynucleotide sequences, screening and/or selection of new recombinant proteins resulting therefrom having a desired biological activity, and especially to production and identification of novel proteases exhibiting desired properties.Type: GrantFiled: March 17, 1998Date of Patent: September 18, 2001Assignee: Novo Nordisk A/SInventors: Torben Vedel Borchert, Titus Kretzschmar, Joel R. Cherry
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Patent number: 6261827Abstract: The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.Type: GrantFiled: July 18, 2000Date of Patent: July 17, 2001Assignee: Novozymes Biotech, Inc.Inventors: Susan L. Elrod, Joel R. Cherry, Aubrey Jones
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Patent number: 6159688Abstract: A method for the construction of a library of recombined polynucleotides from a number of different starting single or double stranded parental DNA templates is disclosed, wherein the starting single or double stranded parental DNA templates represent discrete points in a population of genes encoding evolutionary or synthetic homologues of a peptide having homologies ranging over a broad spectrum from less than 15% to more than 80%, said population exhibiting at least one identification sequence, and whereby said genes are subjected to a gene shuffling procedure to generate shuffled mutants of said population of genes representing additional discrete points between those of said starting templates.Type: GrantFiled: March 18, 1998Date of Patent: December 12, 2000Assignees: Novo Nordisk A/S, Novo Nordisk BioTech, Inc.Inventors: Torben Vedel Borchert, Titus Kretzschmar, Joel R. Cherry, Jesper Vind
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Patent number: 6100057Abstract: The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.Type: GrantFiled: June 9, 1997Date of Patent: August 8, 2000Assignee: Novo Nordisk Biotech, Inc.Inventors: Susan L. Elrod, Joel R. Cherry, Aubrey Jones
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Patent number: 6015783Abstract: The present invention relates to a process for removal or bleaching of soiling or stains present on cellulosic fabric, wherein the fabric is contacted in aqueous medium with a modified enzyme (enzyme hybrid) which comprises a catalytically active amino acid sequence of a non-cellulolytic enzyme linked to an amino acid sequence comprising a cellulose-binding domain. The invention further relates to a detergent composition comprising an enzyme hybrid of the type in question and a surfactant, and to a process for washing soiled or stained cellulosic fabric, wherein the fabric is washed in an aqueous medium to which is added such a detergent composition.Type: GrantFiled: March 6, 1997Date of Patent: January 18, 2000Assignee: Novo Nordisk A/SInventors: Claus von der Osten, Joel R. Cherry, Mads E. Bjornvad, Jesper Vind, Michael Dolberg Rasmussen
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Patent number: 5968883Abstract: The present invention relates to novel variants of Coprinus cinereus peroxidase showing excellent hydrogen peroxide stability.Type: GrantFiled: January 22, 1999Date of Patent: October 19, 1999Assignee: Novo Nordisk A/SInventors: Joel R. Cherry, Allan Svendsen, Ture Damhus, Palle Schneider
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Patent number: 5958747Abstract: The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the 5-aminolevulinic acid synthases.Type: GrantFiled: February 5, 1998Date of Patent: September 28, 1999Assignee: Novo Nordisk Biotech, IncInventors: Susan L. Elrod, Joel R. Cherry
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Patent number: 5891669Abstract: The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which complement the respiratory defect and (ii) a second nucleic acid sequence which encodes the polypeptide; (b) cultivating the cell containing the first and second nucleic acid sequences in a culture medium under aerobic conditions suitable for expression of the first and second nucleic acid sequences; and (c) isolating the polypeptide from the cultivation medium of the cell. The present invention also relates to methods for disrupting a gene in a respiratory-deficient mutant cell. The present invention further relates to respiratory-deficient mutant cells and methods for obtaining such mutant cells.Type: GrantFiled: March 17, 1997Date of Patent: April 6, 1999Assignees: Novo Nordisk A/S, Novoalle,, Novo Nordisk BiotechInventors: Ejner Bech Jensen, Joel R. Cherry, Susan L. Elrod
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Patent number: 5879921Abstract: The invention is directed to alkaline glucose oxidases comprising novel peptide sequences. Furthermore, the invention relates to methods for producing and using said glucose oxidases.Type: GrantFiled: November 7, 1996Date of Patent: March 9, 1999Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.Inventors: Joel R. Cherry, Randy M. Berka, Torben Halkier
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Patent number: 5871991Abstract: The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the 5-aminolevulinic acid synthases.Type: GrantFiled: June 9, 1997Date of Patent: February 16, 1999Assignee: Novo Nordisk BioTech, Inc.Inventors: Susan L. Elrod, Joel R. Cherry
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Patent number: 5866391Abstract: The present invention relates to Aspergillus porphobilinogen synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the porphobilinogen synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the porphobilinogen synthases.Type: GrantFiled: June 9, 1997Date of Patent: February 2, 1999Assignee: Novo Nordisk Biotech, Inc.Inventors: Aubrey Jones, Joel R. Cherry